公开(公告)号：US09522887B2

公开(公告)日：2016-12-20

申请号：US14794430

申请日：2015-07-08

Applicant: DOW AGROSCIENCES LLC

Inventor： James M. Renga ,  Yuanming Zhu ,  Gregory T. Whiteker ,  Nakyen Choy

IPC: C07D213/803 ,  C07D213/79 ,  C07D307/54 ,  C07D213/84

CPC classification number: C07D213/803 ,  C07D213/79 ,  C07D213/84 ,  C07D307/54

Abstract: 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement.

Abstract translation: 4,6-二溴-3-羟基吡啶腈可以从选自氰基胺化，胺盐形成和溴化重排的一系列化学步骤中由糠醛制备。

公开(公告)号：US09475771B2

公开(公告)日：2016-10-25

申请号：US14794471

申请日：2015-07-08

Applicant: DOW AGROSCIENCES LLC

Inventor： James M. Renga ,  Yuanming Zhu ,  Gregory T. Whiteker ,  Nakyen Choy

IPC: C07D213/79 ,  C07D213/803 ,  C07D307/54 ,  C07D213/84

CPC classification number: C07D213/803 ,  C07D213/79 ,  C07D213/84 ,  C07D307/54

Abstract: 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction.

Abstract translation: 4,6-二溴-3-羟基吡啶腈可以从选自氰基胺化，胺盐形成和溴化重排的一系列化学步骤中由糠醛制备。 4-烷氧基-3-羟基吡啶甲酸可以从选自溴取代，腈水解和卤素还原的一系列化学步骤中方便地从4,6-二溴-3-羟基吡啶腈制备。

公开(公告)号：US09102654B2

公开(公告)日：2015-08-11

申请号：US14517587

申请日：2014-10-17

Applicant: Dow AgroSciences LLC

Inventor： Qiang Yang ,  Beth Lorsbach ,  Gary Roth ,  Noormohamed M. Niyaz ,  Jeffrey Nissen ,  Ronald Ross, Jr. ,  Gregory T. Whiteker ,  Carl DeAmicis ,  Kaitlyn Gray ,  Yu Zhang

IPC: C07D401/04 ,  C07D213/77 ,  A01N43/56

CPC classification number: C07D401/04 ,  A01N43/40 ,  A01N43/56 ,  C07D213/77

Abstract: The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.

公开(公告)号：US09085564B2

公开(公告)日：2015-07-21

申请号：US14517595

申请日：2014-10-17

Applicant: Dow AgroSciences LLC

Inventor： Qiang Yang ,  Beth Lorsbach ,  Gregory T. Whiteker ,  Carl DeAmicis ,  Kaitlyn Gray ,  Yu Zhang ,  Joseck M. Muhuhi

IPC: C07D231/40 ,  C07D401/14 ,  A01N43/56 ,  C07D401/04

CPC classification number: C07D401/04 ,  A01N43/56 ,  C07D231/38 ,  C07D231/40 ,  C07D401/14

Abstract: The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.

公开(公告)号：US10550083B2

公开(公告)日：2020-02-04

申请号：US16071516

申请日：2017-01-23

Applicant: Dow AgroSciences LLC

Inventor： Kenneth E. Stockman ,  Gregory T. Whiteker ,  Erich J. Molitor ,  Nakyen Choy

IPC: C07D213/803 ,  C07D213/84 ,  C07D213/79

Abstract: 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction that are conducted as a single pot process. 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement.

公开(公告)号：US10358423B2

公开(公告)日：2019-07-23

申请号：US16035738

申请日：2018-07-16

Applicant: Dow AgroSciences LLC

Inventor： Gregory T. Whiteker ,  Nakyen Choy ,  Peter Borromeo ,  Nicholas R. Babij ,  Gary Roth ,  Patrick S. Hanley ,  Matthias S. Ober ,  Tina Staton ,  Daniel I. Knueppel ,  Grant Von Wald ,  Nicole Hough

IPC: C07C227/18 ,  C07C229/08 ,  C07C269/06 ,  C07C271/22 ,  C07D213/81

Abstract: A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic acid or 4-methoxy-3-hydroxypicolinic acid with a key 2-aminopropanoate ester derived from a 1,1-bis(4-fluorophenyl)propane-1,2-diol.

公开(公告)号：US10259789B2

公开(公告)日：2019-04-16

申请号：US16071512

申请日：2017-01-23

Applicant: Dow AgroSciences LLC

Inventor： Gregory T. Whiteker ,  Peter Borromeo ,  Fangzheng Li ,  Gary Roth

IPC: C07D213/69 ,  C07D213/79 ,  C07D213/803

Abstract: 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction that are conducted as a single pot process. 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-acetoxypicolinic acids may be conveniently prepared from 4-alkoxy-3-hydroxypicolinic acids by treatment with acetic anhydride.

公开(公告)号：US09981911B2

公开(公告)日：2018-05-29

申请号：US15683813

申请日：2017-08-23

Applicant: Dow AgroSciences LLC

Inventor： James M. Renga ,  Gregory T. Whiteker ,  Peter Lee Johnson ,  Christopher Galliford

IPC: C07D213/803 ,  C07D213/79 ,  C07D213/72 ,  C07D213/73 ,  C07C251/12 ,  C07D213/74

CPC classification number: C07D213/803 ,  C07C251/12 ,  C07D213/72 ,  C07D213/73 ,  C07D213/74 ,  C07D213/79

Abstract: 4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps.

公开(公告)号：US09822077B2

公开(公告)日：2017-11-21

申请号：US14304345

申请日：2014-06-13

Applicant: Dow AgroSciences LLC

Inventor： James M. Renga ,  Gregory T. Whiteker ,  Peter L. Johnson ,  Christopher Galliford

IPC: C07D213/08 ,  C07D213/803 ,  C07D213/72 ,  C07C251/12 ,  C07D213/73 ,  C07D213/74 ,  C07D213/79

CPC classification number: C07D213/803 ,  C07C251/12 ,  C07D213/72 ,  C07D213/73 ,  C07D213/74 ,  C07D213/79

Abstract: 4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps.

公开(公告)号：US09481651B2

公开(公告)日：2016-11-01

申请号：US14794450

申请日：2015-07-08

Applicant: DOW AGROSCIENCES LLC

Inventor： James M. Renga ,  Yuanming Zhu ,  Gregory T. Whiteker ,  Nakyen Choy ,  Kenneth E. Stockman

IPC: C07D213/79 ,  C07D213/803 ,  C07D213/84 ,  C07D307/54

CPC classification number: C07D213/803 ,  C07D213/79 ,  C07D213/84 ,  C07D307/54

Abstract: 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction.