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21.
公开(公告)号:US08367660B2
公开(公告)日:2013-02-05
申请号:US12643188
申请日:2009-12-21
申请人: Hayley Binch , Dennis Hurley , Lev T. D. Fanning , Peter D. J. Grootenhuis , Martyn Botfield , Fredrick Van Goor
发明人: Hayley Binch , Dennis Hurley , Lev T. D. Fanning , Peter D. J. Grootenhuis , Martyn Botfield , Fredrick Van Goor
IPC分类号: C07D265/36 , A61K31/538
CPC分类号: A61K31/5415 , A61K31/538 , A61K45/06 , C07D265/36 , C07D279/16 , C07D413/12
摘要: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using such CFTR modulators.
摘要翻译: 本发明涉及ATP结合盒(ABC)转运蛋白或其片段的调节剂,包括囊性纤维化跨膜电导调节剂,其组合物及其方法。 本发明还涉及使用这种CFTR调节剂治疗疾病的方法。
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22.
公开(公告)号:US08314239B2
公开(公告)日:2012-11-20
申请号:US12605250
申请日:2009-10-23
IPC分类号: C07D215/38
CPC分类号: C07D401/14 , C07D487/08 , Y02P20/55
摘要: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
摘要翻译: 本发明涉及囊性纤维化跨膜电导调节剂(CFTR)的调节剂,其组合物及其方法。 本发明还涉及使用CFTR的调节剂治疗疾病的方法。
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公开(公告)号:US07705031B2
公开(公告)日:2010-04-27
申请号:US11933724
申请日:2007-11-01
申请人: Dean M. Wilson , Andreas P. Termin , Jesus E. Gonzalez, III , Nicole Zimmermann , Yulian Zhang , Lev T. D. Fanning
发明人: Dean M. Wilson , Andreas P. Termin , Jesus E. Gonzalez, III , Nicole Zimmermann , Yulian Zhang , Lev T. D. Fanning
IPC分类号: A61K31/4184 , A61K31/165
CPC分类号: C07D405/12 , C04B35/632 , C07D209/42 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D409/12 , C07D413/12
摘要: The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及式I化合物或其药学上可接受的盐,其中式I的R 1,Z,Y,RA和W基团如本文所定义。 本发明还提供药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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