公开(公告)号：US20070054936A1

公开(公告)日：2007-03-08

申请号：US11360084

申请日：2006-02-23

申请人： Nareshkumar Jain ,  Jiayi Xu ,  Zhihua Sui

发明人： Nareshkumar Jain ,  Jiayi Xu ,  Zhihua Sui

IPC分类号： A61K31/47 ,  C07D215/38

CPC分类号： C07D215/54

摘要： The present invention is directed to novel quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to ion channels such as potassium channels.

摘要翻译： 本发明涉及新颖的喹啉衍生物，含有它们的药物组合物及其在治疗与离子通道如钾通道有关的病症中的用途。

公开(公告)号：US20070054935A1

公开(公告)日：2007-03-08

申请号：US11360726

申请日：2006-02-23

申请人： Nareshkumar Jain ,  Jiayi Xu ,  Zhihua Sui

发明人： Nareshkumar Jain ,  Jiayi Xu ,  Zhihua Sui

IPC分类号： A61K31/4741 ,  A61K31/455 ,  C07D491/02 ,  C07D211/82

CPC分类号： C07D213/48 ,  C07D213/30 ,  C07D213/50 ,  C07D213/57 ,  C07D215/54 ,  C07D491/04 ,  C07F7/1804

摘要： The present invention is directed to novel pyridine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to ion channels such as potassium channels.

摘要翻译： 本发明涉及新颖的吡啶衍生物，含有它们的药物组合物及其用于治疗与离子通道如钾通道有关的疾病的用途。

公开(公告)号：US07671065B2

公开(公告)日：2010-03-02

申请号：US11360726

申请日：2006-02-23

申请人： Nareshkumar Jain ,  Jiayi Xu ,  Zhihua Sui

发明人： Nareshkumar Jain ,  Jiayi Xu ,  Zhihua Sui

IPC分类号： A61K31/435 ,  A61K31/44 ,  C07D211/70 ,  C07D471/02

CPC分类号： C07D213/48 ,  C07D213/30 ,  C07D213/50 ,  C07D213/57 ,  C07D215/54 ,  C07D491/04 ,  C07F7/1804

摘要： The present invention is directed to novel pyridine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to ion channels such as potassium channels.

摘要翻译： 本发明涉及新颖的吡啶衍生物，含有它们的药物组合物及其用于治疗与离子通道如钾通道有关的疾病的用途。

公开(公告)号：US07790895B2

公开(公告)日：2010-09-07

申请号：US11360084

申请日：2006-02-23

申请人： Nareshkumar Jain ,  Jiayi Xu ,  Zhihua Sui

发明人： Nareshkumar Jain ,  Jiayi Xu ,  Zhihua Sui

IPC分类号： C07D215/38

CPC分类号： C07D215/54

摘要： The present invention is directed to novel quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to ion channels such as potassium channels.

摘要翻译： 本发明涉及新颖的喹啉衍生物，含有它们的药物组合物及其在治疗与离子通道如钾通道有关的病症中的用途。

公开(公告)号：US07329654B2

公开(公告)日：2008-02-12

申请号：US10307735

申请日：2002-12-02

申请人： Ramesh M. Kanojia ,  Nareshkumar F. Jain ,  Raymond Ng ,  Zhihua Sui ,  Jiayi Xu

发明人： Ramesh M. Kanojia ,  Nareshkumar F. Jain ,  Raymond Ng ,  Zhihua Sui ,  Jiayi Xu

IPC分类号： A61P19/10 ,  A61K31/35 ,  C07D493/04

CPC分类号： C07D493/04

摘要： The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and/or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.

摘要翻译： 本发明涉及新颖的含杂原子的四环衍生物，含有它们的药物组合物，它们在治疗和/或预防由一种或多种雌激素受体介导的障碍及其制备方法中的用途。 本发明的化合物可用于治疗和/或预防与雌激素消耗相关的疾病，例如潮热，阴道干燥，骨质减少和骨质疏松症; 激素敏感性癌症和乳腺，子宫内膜，子宫颈和前列腺增生; 子宫内膜异位症，子宫肌瘤，骨关节炎和避孕药，单独或与孕激素或孕激素拮抗剂联合使用。