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21.发明申请Biosensor, thin film electrode forming method, quantification apparatus, and quantificaion method 有权生物传感器，薄膜电极形成方法，定量装置和定量方法公开(公告)号：US20090152111A1
公开(公告)日：2009-06-18
申请号：US12322684
申请日：2009-02-05
IPC分类号： C12M1/00
CPC分类号： G01N27/3272 , C12Q1/001 , G01N33/48771 , Y10T29/49002
摘要： A biosensor according to the present invention comprises a support 1, a conductive layer 2 composed of an electrical conductive material such as noble metal, for example gold, palladium or the like, and carbon, slits 3a and 3b parallel to the side of the support 1, slits 4a and 4b vertical to the side of the support 1, a working electrode 5, a counter electrode 6, a detecting electrode 7, a spacer 8 which covers the working electrode 5, the counter electrode 6 and the detecting electrode 7 on the support 1, a rectangular cutout part 9 forming a specimen supply path, an inlet 9a of the specimen supply path, a reagent layer 12 formed by applying a reagent including an enzyme or the like to the working electrode 5, the counter electrode 6 and the detecting electrode 7, which is exposed from the cutout part 9 of the spacer 8, and a cover 13 which covers the spacer 8, as shown in FIG. 1. The so-constructed biosensor can be formed by a simple method, and a biosensor which is excellent in a measuring accuracy as well as a biosensor in which a reagent layer is placed uniformly on the electrodes regardless of a reagent liquid composition, and which has a uniform performance can be realized.
摘要翻译： 根据本发明的生物传感器包括支撑体1，由诸如金，钯等的诸如贵金属的导电材料构成的导电层2和碳，平行于载体侧的狭缝3a和3b 如图1所示，与支撑体1侧垂直的狭缝4a，4b，工作电极5，对电极6，检测电极7，覆盖工作电极5的间隔件8，对置电极6和检测电极7 支撑体1，形成试样供给路径的矩形切口部9，试料供给路径的入口9a，通过将包含酶等的试剂涂布在工作电极5上而形成的试剂层12，对电极6和 从间隔件8的切口部9露出的检测电极7和覆盖间隔件8的盖13，如图1所示。 如此构造的生物传感器可以通过简单的方法形成，并且测量精度优异的生物传感器以及试剂层均匀地放置在电极上而不考虑试剂液体组成的生物传感器，并且其中 具有统一的性能可以实现。
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公开(公告)号：US20050194251A1
公开(公告)日：2005-09-08
申请号：US11106078
申请日：2005-04-14
申请人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Takahiro Nakaminami , Junko Nakayama , Eriko Yamanishi
发明人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Takahiro Nakaminami , Junko Nakayama , Eriko Yamanishi
CPC分类号： C12Q1/003
摘要： In a biosensor for measuring a specific substance in a liquid sample, one or a combination of sugar alcohol, metallic salt, organic acid or organic acid salt which has at least one carboxyl group in a molecule, and organic acid or organic acid salt which has at least one carboxyl group and one amino group in a molecule, is included in a reagent layer provided on electrodes, thereby providing a highly-accurate biosensor which is excellent in stability and has high response (sensitivity, linearity) of the sensor to the substrate concentration.
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公开(公告)号：USD438311S1
公开(公告)日：2001-02-27
申请号：US29117288
申请日：2000-01-21
申请人： Eriko Yamanishi , Shoji Miyazaki , Masaki Fujiwara
设计人： Eriko Yamanishi , Shoji Miyazaki , Masaki Fujiwara
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公开(公告)号：US06309526B1
公开(公告)日：2001-10-30
申请号：US09384103
申请日：1999-08-26
IPC分类号： G01N2726
CPC分类号： G01N27/3272 , G01N33/525
摘要： A biosensor is fabricated by forming a metal film over the surface of a substrate through evaporation, sputtering or by gluing a metal foil, then splitting the metal film into three regions, and forming a reagent layer on an area of measuring electrode and two counter-electrodes for placing a liquid sample on by providing a cover disposed over the splitted metal film. As neither of the electrodes are formed through conventional printing technology, the electrodes can be formed without dispersion. As a result, a precision biosensor having excellent response characteristics is implemented.
摘要翻译： 通过蒸发，溅射或粘合金属箔在基板的表面上形成金属膜，然后将金属膜分割成三个区域，并在测量电极的区域上形成试剂层， 用于通过提供设置在分离的金属膜上的盖来放置液体样品的电极。 由于既不通过常规印刷技术形成电极，也可以不分散地形成电极。 结果，实现了具有优异的响应特性的精密生物传感器。
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25.发明授权Biosensor, thin film electrode forming method, quantification apparatus, and quantification method 有权生物传感器，薄膜电极形成方法，定量装置和定量方法公开(公告)号：US08470162B2
公开(公告)日：2013-06-25
申请号：US12930957
申请日：2011-01-20
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , G01N33/48771 , Y10T29/49002
摘要： Quantifying devices and methods are disclosed for quantifying substrate content using a biosensor where the methods include a first detecting step for detecting an electrical change generated between a measuring electrode and a counter electrode of a biosensor by applying a sample liquid to the biosensor; a second detecting step for detecting an electrical change generated between a detecting electrode of the biosensor and the counter electrode or the measuring electrode by applying the sample liquid to the biosensor; and a notification step for informing a user when the second detecting step does not occur within a predetermined period after the first detecting step.
摘要翻译： 公开了量子化装置和方法，用于使用生物传感器量化衬底含量，其中所述方法包括：通过将样品液体施加到生物传感器来检测在生物传感器的测量电极和对电极之间产生的电变化的第一检测步骤; 第二检测步骤，用于通过将样品液体施加到生物传感器来检测在生物传感器的检测电极与对电极或测量电极之间产生的电变化; 以及通知步骤，用于在第一检测步骤之后的预定时间段内通知用户何时第二检测步骤不发生。
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26.发明授权Biosensor, thin film electrode forming method, quantification apparatus, and quantification method 有权生物传感器，薄膜电极形成方法，定量装置和定量方法公开(公告)号：US08480867B2
公开(公告)日：2013-07-09
申请号：US13135848
申请日：2011-07-15
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , G01N33/48771 , Y10T29/49002
摘要： Apparatus are disclosed for measuring substrate content present in a specimen that is applied to a biosensor, where the apparatus include an input for receiving an electrical signal from the biosensor; and a circuit coupled to the input to detect the electrical signal to determine whether an amount of the specimen needed for specimen detection has been supplied to the biosensor; where the apparatus measures the substrate content included in the specimen when the circuit determines that an amount of the specimen needed for specimen detection has been supplied to the biosensor, and the apparatus is prevented from measuring the substrate content included in the specimen when the circuit determines that the specimen has not been sufficiently supplied to the biosensor.
摘要翻译： 公开了用于测量施加到生物传感器的样本中存在的底物含量的装置，其中装置包括用于从生物传感器接收电信号的输入端; 以及电路，其耦合到所述输入端以检测所述电信号，以确定是否向所述生物传感器提供了所述样本检测所需的样本量; 其中当电路确定样本检测所需的样本量已被提供给生物传感器时，该装置测量包含在样本中的基底含量，并且当电路确定时检测装置被测量包含在样本中的基底含量 样品没有被充分供应给生物传感器。
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27.发明授权Biosensor, thin film electrode forming method, quantification apparatus, and quantification method 有权生物传感器，薄膜电极形成方法，定量装置和定量方法公开(公告)号：US08475646B2
公开(公告)日：2013-07-02
申请号：US13135816
申请日：2011-07-15
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , G01N33/48771 , Y10T29/49002
摘要： Methods are disclosed for measuring substrate content in a specimen using a biosensor that includes two pairs of electrodes in a specimen supply path, where the methods include the steps of: (a) a first detecting step for detecting an electrical change in the first pair of electrodes; (b) a second detecting step for detecting an electrical change in the second pair of electrodes after the first detecting step; (c) a judging step for judging a shortage of specimen amount that is needed for measurement, when an electrical change is not detected in the second detecting step within a prescribed period of time after the first detecting step; (d) an indicating step for indicating a shortage of the specimen amount; and (e) a stopping step for stopping measurement of substrate content in the specimen once the shortage of specimen amount is indicated in the indicating step.
摘要翻译： 公开了用于使用在样本供应路径中包括两对电极的生物传感器来测量样品中的基底含量的方法，其中所述方法包括以下步骤：（a）第一检测步骤，用于检测第一对中的电变化 电极 （b）第二检测步骤，用于在第一检测步骤之后检测第二对电极中的电变化; （c）当在第一检测步骤之后的规定时间内没有在第二检测步骤中检测到电变化时，判断测量所需的试样量的不足的判断步骤; （d）指示样本量不足的指示步骤; 和（e）一旦在指示步骤中指示了样本量不足，则停止步骤，用于停止测量样本中的基底含量。
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公开(公告)号：US6004441A
公开(公告)日：1999-12-21
申请号：US889929
申请日：1997-07-10
IPC分类号： G01N27/327 , G01N27/403 , G01N33/487 , G01N33/52 , G01N27/26
CPC分类号： G01N27/3272 , G01N33/525 , Y10T156/1082
摘要： A biosensor is fabricated by forming a metal film over the surface of a substrate through evaporation, sputtering or by gluing a metal foil, then splitting the metal film into three regions, and forming a reagent layer on an area of measuring electrode and two counter-electrodes for placing a liquid sample on by providing a cover disposed over the splitted metal film. As neither of the electrodes are formed through conventional printing technology, the electrodes can be formed without dispersion. As a result, a precision biosensor having excellent response characteristics is implemented.
摘要翻译： 通过蒸发，溅射或粘合金属箔在基板的表面上形成金属膜，然后将金属膜分割成三个区域，并在测量电极的区域上形成试剂层， 用于通过提供设置在分离的金属膜上的盖来放置液体样品的电极。 由于既不通过常规印刷技术形成电极，也可以不分散地形成电极。 结果，实现了具有优异的响应特性的精密生物传感器。
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公开(公告)号：US09223209B2
公开(公告)日：2015-12-29
申请号：US12709346
申请日：2010-02-19
CPC分类号： G03F7/0046 , G03F7/0392 , G03F7/0397 , G03F7/11 , G03F7/2041 , G03F7/322 , G03F7/325
摘要： Provided are sulfonamide-containing photoresist compositions for use in lithographic processes that have improved properties for high resolution, low blur imaging. Also provided are alcohol-soluble photoresists for resist-on-resist applications. The sulfonamide-containing photoresist compositions of the present invention include positive-tone photoresist compositions that have sulfonamide-substituted repeat units with branched linking group as shown in Formula (I):
摘要翻译： 提供了用于光刻工艺的含磺酰胺的光致抗蚀剂组合物，其具有用于高分辨率，低模糊成像的改进的性质。 还提供了用于抗蚀剂抗蚀剂应用的醇溶性光致抗蚀剂。 本发明的含磺酰胺的光致抗蚀剂组合物包括具有如式（I）所示的具有支链连接基团的磺酰胺取代的重复单元的正色调光致抗蚀剂组合物：
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30.发明授权Biosensor system, sensor chip, and method of measuring analyte concentration in blood sample 有权生物传感器系统，传感器芯片和测量血液样品中分析物浓度的方法公开(公告)号：US08940138B2
公开(公告)日：2015-01-27
申请号：US12935803
申请日：2009-04-02
申请人： Masaki Fujiwara
发明人： Masaki Fujiwara
CPC分类号： G01N27/3273 , C12Q1/26 , G01N27/3274
摘要： The present biosensor system prevents a measurement error caused by the temperature of the environment in use. A biosensor system 100 includes a measuring instrument 101 having an operation part 306, and a sensor chip 200 insertable into and removable from the measuring instrument 101 and which accepts a blood sample. The sensor chip 200 includes a measurement part 41 that acquires Data a related to the concentration of an analyte in a blood sample based on the amount of electric current that flows in the sample due to a reaction in which an oxidoreductase with the analyte used as a substrate is involved, and a measurement part 42 that acquires, from the sample, Data b for temperature correction of Data a. The operation part 306 determines the concentration of the analyte in the sample, corrected according to the temperature of the sample based on Data a and Data b.
摘要翻译： 本生物传感器系统防止由使用环境的温度引起的测量误差。 生物传感器系统100包括具有操作部306的测量仪器101和可插入测量仪器101并可从测量仪器101移除并且接受血液样本的传感器芯片200。 传感器芯片200包括测量部分41，该测量部分41基于由于其中使用分析物的氧化还原酶的反应而在样品中流动的电流量来获取与血液样品中的分析物的浓度相关的Data a 涉及基板;以及测量部42，其从该样本获取用于Data a的温度校正的Data b。 操作部306根据数据a和数据b，根据样本的温度来确定样品中分析物的浓度。
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