公开(公告)号：US07332117B2

公开(公告)日：2008-02-19

申请号：US10847077

申请日：2004-05-17

申请人： Paul Higham ,  Philip F. Williams, III ,  John Lapszynski ,  Chau Ngo

发明人： Paul Higham ,  Philip F. Williams, III ,  John Lapszynski ,  Chau Ngo

IPC分类号： B29C71/00

CPC分类号： A61F2/442 ,  A61F2002/444 ,  A61L27/52 ,  B29C45/00 ,  Y10S524/916

摘要： A high strength hydrogel having a constant swelling pressure upon implantation and thereafter is formed by preparing a hydrogel solution and then injecting the solution into a mold and cause to gel. The molded gel is then washed in a saline solution from about one day to twelve weeks, after which the gel is irradiated for sterilization purposes, dehydrated and packaged. The pre-treatment with the use of a physiologic solution results in an implant which exhibits a constant swelling pressure profile after implantation.

摘要翻译： 通过制备水凝胶溶液然后将溶液注入模具并使其凝胶化，形成植入后具有恒定溶胀压力的高强度水凝胶。 然后将模制的凝胶在盐水溶液中洗涤约1天至12周，此后将凝胶照射灭菌，脱水并包装。 使用生理溶液的预处理导致植入物在植入后呈现恒定的溶胀压力分布。

公开(公告)号：US20070270786A1

公开(公告)日：2007-11-22

申请号：US11399155

申请日：2006-04-06

申请人： Paul Higham ,  Robert Klein

发明人： Paul Higham ,  Robert Klein

IPC分类号： A61B18/18

CPC分类号： C08F265/04

摘要： A method for accelerating the set time of acrylic bones cements uses ultrasonic energy. Typically acrylic bone cements comprise a mixture of a liquid monomer and a powdered polymer which sets over a period of time to form a hardened material. After the bone cement has been placed in the body the polymerization rate or set time may be increased by the application of ultrasonic sound energy. A horn of an ultrasonic generator is placed in or adjacent to the unset bone cement mixture and acoustic energy is applied which energy accelerates the set time. Typically the frequency is in the range of 20 KHz and an amplitude of between 5 and 30 μm with an application time of between 40 seconds and 2 minutes.

摘要翻译： 加速丙烯酸骨水泥凝固时间的方法使用超声波能量。 通常，丙烯酸骨水泥包括液体单体和粉末聚合物的混合物，其在一段时间内设置以形成硬化材料。 在将骨水泥放置在体内之后，通过施加超声波能量可以增加聚合速度或设定时间。 将超声波发生器的角放置在未固定的骨水泥混合物中或邻近未凝固的骨水泥混合物，并且施加声能，其能量加速了凝固时间。 通常，频率在20KHz的范围内，振幅在5到30um之间，施加时间在40秒和2分钟之间。

公开(公告)号：US20070213425A1

公开(公告)日：2007-09-13

申请号：US11370681

申请日：2006-03-08

申请人： Paul Higham ,  Shulin He

发明人： Paul Higham ,  Shulin He

IPC分类号： A61K6/08

CPC分类号： A61L24/06 ,  A61L27/16 ,  A61L2430/02 ,  C08L33/12

摘要： An acrylic bone cement composition, including a liquid monomer component and a polymer powder component in the form of beads. The liquid monomer component includes a methylmethacrylate polymer and the polymer component includes a polymethylmethacrylate polymer powder, wherein the polymer powder component is subjected to a milling process.

摘要翻译： 一种丙烯酸骨水泥组合物，包括液体单体组分和珠粒形式的聚合物粉末组分。 液体单体组分包括甲基丙烯酸甲酯聚合物，聚合物组分包括聚甲基丙烯酸甲酯聚合物粉末，其中聚合物粉末组分经受研磨过程。

公开(公告)号：US20060255503A1

公开(公告)日：2006-11-16

申请号：US11491703

申请日：2006-07-24

申请人： Paul Higham ,  Chau Ngo ,  Christopher DeMaria ,  Philip Williams

发明人： Paul Higham ,  Chau Ngo ,  Christopher DeMaria ,  Philip Williams

IPC分类号： B29C41/22

CPC分类号： A61L27/52 ,  A61F2/30965 ,  A61F2/441 ,  A61F2/442 ,  A61F2002/3008 ,  A61F2002/30616 ,  A61F2002/30971 ,  A61F2002/444 ,  A61F2250/0064 ,  A61F2250/0098 ,  A61F2310/00023 ,  A61F2310/00131 ,  A61F2310/00137 ,  A61F2310/00149 ,  A61F2310/00155 ,  A61L27/50 ,  A61L2430/38

摘要： A spinal implant for replacing the natural nucleus of the disc made from a polymer such as hydrogel having a radiopaque material located within the polymer. The material may be in the form of a powder dispersed throughout the polymer or may be in he form of a powder dispersed in layers or in other specific locations within the polymer. The radiopaque material is metal such as gold, tungsten, titanium, tantalum or platinum. The metal may also be in the form of a foil or wire located within the hydrogel such as polyurethane, thereby making the implant visible on x-rays. Other polymers besides hydrogel may be used with the radiopaque material being dispersed therein.

摘要翻译： 用于替换由诸如水凝胶的聚合物制成的盘的天然核的脊椎植入物，其具有位于聚合物内的不透射线材料。 该材料可以是分散在整个聚合物中的粉末的形式，或者可以是分散在聚合物中的层或其它特定位置的粉末形式。 不透射线的材料是诸如金，钨，钛，钽或铂的金属。 金属也可以是位于水凝胶内的箔或线的形式，例如聚氨酯，从而使植入物在x射线上可见。 除了水凝胶之外的其它聚合物可以与不透射线材料分散在其中一起使用。

公开(公告)号：US20050169964A1

公开(公告)日：2005-08-04

申请号：US11059864

申请日：2005-02-17

申请人： Joseph Zitelli ,  Paul Higham ,  Paresh Dalal ,  Christopher Scott

发明人： Joseph Zitelli ,  Paul Higham ,  Paresh Dalal ,  Christopher Scott

IPC分类号： A61L27/32 ,  A61L27/54 ,  A61L2/00 ,  A61K9/14

CPC分类号： A61L27/54 ,  A61L27/32 ,  A61L2300/252 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/606

摘要： A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein such as OP-1 protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.

摘要翻译： 将具有治疗剂如抗生素或骨形态发生蛋白如OP-1蛋白的涂层施用于植入物的方法使用磷酸钙涂覆的金属植入物的高表面积作为治疗剂的储存库。 植入物涂覆有一层或多层磷酸钙矿物质，如羟基磷灰石。 在通常在水溶液中进行结晶层之后，将植入物干燥并包装。 在植入之前，立即从包装中取出植入物，并用含有治疗剂的水溶液润湿磷酸钙的结晶层。

公开(公告)号：US06849275B2

公开(公告)日：2005-02-01

申请号：US10340442

申请日：2003-01-10

申请人： Paul Higham

发明人： Paul Higham

IPC分类号： A61F2/00 ,  A61F2/28 ,  A61F2/46 ,  A61L27/12 ,  A61K33/42 ,  A61K9/14 ,  A61K47/00 ,  C01B25/00 ,  C04B12/02

CPC分类号： A61L27/12 ,  A61F2/28 ,  A61F2002/4631 ,  A61F2310/00293 ,  Y10S514/951 ,  Y10S514/952

摘要： A method for controlling the formation of a hydroxyapatite bone filler from dry calcium phosphate precursors in an aqueous solution uses coated sodium phosphate powder. The sodium phosphate powder is coated with a water soluble cellulose. Until the cellulose dissolves in the aqueous solution setting of the calcium phosphate cements proceeds slowly but when the exposed sodium phosphate particles start to solubilize in the aqueous solution the setting rate increases.

摘要翻译： 用于控制水溶液中干磷酸钙前体形成羟基磷灰石骨填料的方法使用涂覆的磷酸钠粉末。 磷酸钠粉末涂有水溶性纤维素。 直到纤维素溶解在磷酸钙水泥的水溶液中才缓慢进行，但是当暴露的磷酸钠颗粒开始溶解在水溶液中时，凝固速率增加。

公开(公告)号：US06547866B1

公开(公告)日：2003-04-15

申请号：US09699662

申请日：2000-10-30

申请人： Brian Edwards ,  Paul Higham ,  Joseph Zitelli

发明人： Brian Edwards ,  Paul Higham ,  Joseph Zitelli

IPC分类号： A61L2402

CPC分类号： A61L24/02 ,  A61L2430/02 ,  C04B28/344 ,  C04B38/02 ,  C04B2111/00836 ,  C04B22/10 ,  C04B24/04 ,  C04B24/06 ,  C04B22/165

摘要： A kit and a method for making a porous cement which self sets to hydroxyapatite and has an interconnected porosity is produced by mixing a calcium source and a phosphate source with a carbonate source and mixing this powdered component with a liquid component having an acid component. The liquid component comprises water or an aqueous solution containing an acid. The acid and the carbonate react to form carbon dioxide thereby producing an interconnected porosity in the normally solid self-hardening bone cement. The method requires only a relatively low weight percent of the acid and base to be mixed with the liquid and powder cement components.

公开(公告)号：US08209003B2

公开(公告)日：2012-06-26

申请号：US12854778

申请日：2010-08-11

申请人： Paul Higham

发明人： Paul Higham

IPC分类号： A61B5/0402

CPC分类号： A61B5/0452 ,  A61B5/04023 ,  A61B5/7239

摘要： A morphology discrimination scheme extracts shape characteristics from cardiac signals and identifies an associated cardiac condition based on the shape characteristics. For example, internal data structures may be updated to match the shape characteristics of a known condition (e.g., a patient's normal sinus rhythm). Similarly acquired shape characteristics obtained in conjunction with a later event (e.g., QRS complexes acquired during a tachycardia episode) may be compared with the previously stored shape characteristics to characterize the later event. In some aspects the shape characteristics relate to inflection points of cardiac signals.

摘要翻译： 形态鉴别方案从心脏信号中提取形状特征，并基于形状特征识别相关的心脏病状。 例如，可以更新内部数据结构以匹配已知条件（例如，患者的正常窦性心律）的形状特征。 可以将结合较晚事件获得的类似获得的形状特征（例如在心动过速发作期间获得的QRS复合物）与先前存储的形状特征进行比较以表征后面的事件。 在某些方面，形状特征涉及心脏信号的拐点。

公开(公告)号：US20100324435A1

公开(公告)日：2010-12-23

申请号：US12854778

申请日：2010-08-11

申请人： Paul Higham

发明人： Paul Higham

IPC分类号： A61B5/0402

CPC分类号： A61B5/0452 ,  A61B5/04023 ,  A61B5/7239

摘要： A morphology discrimination scheme extracts shape characteristics from cardiac signals and identifies an associated cardiac condition based on the shape characteristics. For example, internal data structures may be updated to match the shape characteristics of a known condition (e.g., a patient's normal sinus rhythm). Similarly acquired shape characteristics obtained in conjunction with a later event (e.g., QRS complexes acquired during a tachycardia episode) may be compared with the previously stored shape characteristics to characterize the later event. In some aspects the shape characteristics relate to inflection points of cardiac signals.

摘要翻译： 形态鉴别方案从心脏信号中提取形状特征，并基于形状特征识别相关的心脏病状。 例如，可以更新内部数据结构以匹配已知条件（例如，患者的正常窦性心律）的形状特征。 可以将结合较晚事件获得的类似获得的形状特征（例如在心动过速发作期间获得的QRS复合物）与先前存储的形状特征进行比较以表征后面的事件。 在某些方面，形状特征涉及心脏信号的拐点。

公开(公告)号：US07801594B1

公开(公告)日：2010-09-21

申请号：US11876518

申请日：2007-10-22

申请人： Paul Higham

发明人： Paul Higham

IPC分类号： A61B5/04

CPC分类号： A61B5/0452 ,  A61B5/04023 ,  A61B5/7239

摘要： A morphology discrimination scheme extracts shape characteristics from cardiac signals and identifies an associated cardiac condition based on the shape characteristics. For example, internal data structures may be updated to match the shape characteristics of a known condition (e.g., a patient's normal sinus rhythm). Similarly acquired shape characteristics obtained in conjunction with a later event (e.g., QRS complexes acquired during a tachycardia episode) may be compared with the previously stored shape characteristics to characterize the later event. In some aspects the shape characteristics relate to inflection points of cardiac signals.

摘要翻译： 形态鉴别方案从心脏信号中提取形状特征，并基于形状特征识别相关的心脏病状。 例如，可以更新内部数据结构以匹配已知条件（例如，患者的正常窦性心律）的形状特征。 可以将结合较晚事件获得的类似获得的形状特征（例如在心动过速发作期间获得的QRS复合物）与先前存储的形状特征进行比较以表征后面的事件。 在某些方面，形状特征涉及心脏信号的拐点。