公开(公告)号：US4394526A

公开(公告)日：1983-07-19

申请号：US191203

申请日：1980-09-26

Applicant: Gerd Leston

Inventor： Gerd Leston

IPC: C07C37/86 ,  C07C39/07 ,  C07C37/68 ,  C07C37/66

CPC classification number: C07C37/86 ,  C07C39/235

Abstract: Para-cresol is separated from a mixture comprising meta-cresol and various other methylated and ethylated phenols by preferentially complexing the para-cresol with one or more anhydrous or dehydrated inorganic salts selected from the group consisting of calcium bromide, lithium bromide, manganese bromide and magnesium chloride. The anhydrous inorganic salt is added to the phenolic mixture in an amount to give a mole ratio of salt to para-cresol in the mixture in the range of about 0.5 mole to one to about 1.5 mole to one. The para-cresol and salt form a complex and the complex is removed from the mixture of methylated and ethylated phenols. Then the complex is decomposed to recover the para-cresol and salt; the recovered salt may be recycled to complex with more para-cresol.

Abstract translation: 通过优选地将对甲酚与一种或多种选自溴化钙，溴化锂，溴化锰的无水或脱水的无机盐优先络合，将对甲酚与包含间甲酚和各种其它甲基化和乙基化酚的混合物分离， 氯化镁。 将无水无机盐加入到酚类混合物中，其量使混合物中盐与对甲酚的摩尔比在约0.5摩尔至1至约1.5摩尔的范围内。 对甲酚和盐形成络合物，并从甲基化和乙基化酚的混合物中除去络合物。 然后将复合物分解以回收对甲酚和盐; 回收的盐可以被再循环以与更多的对甲酚复合。

公开(公告)号：US4267392A

公开(公告)日：1981-05-12

申请号：US053532

申请日：1979-06-29

Applicant: Gerd Leston

Inventor： Gerd Leston

IPC: C07C37/86 ,  C07C37/68 ,  C07C37/74

CPC classification number: C07C37/86 ,  C07C37/685 ,  C07C37/84

Abstract: Para-cresol and meta-cresol are separated from a mixture of methylated and ethylated phenols by a two-stage process wherein the para-cresol is preferentially complexed with one or more anhydrous or dehydrated inorganic salts selected from calcium bromide, lithium bromide, manganese bromide and magnesium chloride. Then the meta-cresol is successively preferentially complexed with calcium bromide from the mixture of methylated and ethylated phenols from which the para-cresol complex has been removed. The anhydrous or dehydrated inorganic salt is added to the mixture of methylated and ethylated phenols including para-cresol and meta-cresol in an amount to give a mole ratio of the salt to para-cresol in the mixture in the range of about 0.5 to one to about 1.5 to one. The para-cresol-salt complex is removed from the mixture of methylated and ethylated phenols and then decomposed to recover the para-cresol. The mixture of methylated and ethylated phenols including meta-cresol from which the para-cresol has been removed has added to it calcium bromide in an amount to give a mole ratio of calcium bromide to meta-cresol in the mixture in the range of about 0.5 to one to around 1.0 to one. The addition is performed in the presence of a non-aqueous solvent and at a temperature in the range of -10.degree. C. to about 40.degree. C. The meta-cresol-salt complex is separated from the second mixture of methylated and ethylated phenols and the complex is decomposed to produce a high purity meta-cresol.

Abstract translation: 对甲酚和间甲酚通过两阶段方法从甲基化和乙基化酚的混合物中分离，其中对甲酚优选与一种或多种选自溴化钙，溴化锂，溴化锰的无水或脱水无机盐络合 和氯化镁。 然后，甲基化和乙基化酚与已经除去对甲酚络合物的混合物中的间甲酚依次优先与溴化钙络合。 将无水或脱水的无机盐加入到甲基化和乙基化酚（包括对甲酚和间甲酚）的混合物中，其量使混合物中的盐与对甲酚的摩尔比在约0.5至1的范围内 至约1.5比1。 从甲基化和乙基化酚的混合物中除去对甲酚 - 盐络合物，然后分解以回收对甲酚。 已经除去对甲酚的甲基化和乙基化酚包括间甲酚的混合物在其中加入溴化钙，其量使混合物中溴化钙与间甲酚的摩尔比在约0.5的范围内 到一到大约1.0比1。 加入在非水溶剂的存在下进行，并在-10℃至约40℃的温度下进行。将间甲酚盐复合物与甲基化和乙基化酚的第二混合物分离 并且复合物被分解以产生高纯度的间甲酚。

公开(公告)号：US4267391A

公开(公告)日：1981-05-12

申请号：US53531

申请日：1979-06-29

Applicant: Gerd Leston

Inventor： Gerd Leston

IPC: C07C37/86 ,  C07C37/68 ,  C07C37/74

CPC classification number: C07C37/86 ,  C07C37/685 ,  C07C37/84

Abstract: A process is disclosed for the stepwise separation of para-cresol and meta-cresol from a mixture of methylated and ethylated phenols. The para-cresol preferentially forms a complex with a dehydrated or anhydrous inorganic salt selected from the group consisting of calcium bromide, lithium bromide, manganese bromide and magnesium chloride. The meta-cresol isomer is separated from the mixture by formation of a complex with urea. Where the anhydrous or dehydrated inorganic salt is added firstly to the mixture of methylated and ethylated phenols including para-cresol and meta-cresol, the salt is provided in an amount to give a mole ratio of the salt to para-cresol in the mixture in the range of about 0.5 to one to about 1.5 to one. The para-cresol complexes with the salt and the complex is then removed from the mixture. The para-cresol-salt complex is thereafter decomposed to recover the para-cresol. The mixture of methylated and ethylated phenols including meta-cresol from which the para cresol has been removed has added to it urea in an amount to give a mole ratio of urea to meta-cresol in the mixture in the range of about 0.7 to one to about 1.3 to one. The meta-cresol-urea complex is then separated from the mixture of methylated and ethylated phenols and thereafter the complex is decomposed by hydrolysis to produce a high purity meta-cresol. It is a feature of the invention that either of the complexing steps may be performed first; that is, either of the anhydrous salt or the urea may be added to the mixture, followed thereafter by addition of the other complexing agent.

Abstract translation: 公开了从甲基化和乙基化酚的混合物中逐步分离对甲酚和间甲酚的方法。 对甲酚优先与选自溴化钙，溴化锂，溴化锰和氯化镁的脱水或无水无机盐形成络合物。 通过与尿素形成络合物将间甲酚异构体与混合物分离。 当将无水或脱水的无机盐首先加入到甲基化和乙基化酚（包括对甲酚和间甲酚）的混合物中时，其盐的量提供了混合物中的盐与对甲酚的摩尔比 在约0.5至1至约1.5比1的范围内。 然后从混合物中除去与盐和络合物的对甲酚复合物。 然后将对甲酚盐复合物分解，以回收对甲酚。 已经除去对甲酚的甲基化和乙基化酚的混合物包括间甲酚的混合物已经向其中加入了尿素，其量使混合物中的脲与间甲酚的摩尔比在约0.7:1至 约1.3比1。 然后将间甲酚 - 脲复合物从甲基化和乙基化酚的混合物中分离，然后通过水解分解复合物以产生高纯度的间甲酚。 本发明的特征在于可以首先执行任一个复合步骤; 也就是说，可以将任一种无水盐或尿素加入到混合物中，随后加入其它络合剂。