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公开(公告)号:US10710986B2
公开(公告)日:2020-07-14
申请号:US16274106
申请日:2019-02-12
发明人: Evangelos Aktoudianakis , Aesop Cho , Zhimin Du , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Prasenjit Kumar Mukherjee , Devan Naduthambi , Eric Q. Parkhill , Barton W. Phillips , Scott Preston Simonovich , Neil H. Squires , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC分类号: C07D403/14 , A61P31/20 , A61P35/02 , A61K31/496 , C07D519/00 , C07D241/20 , C07D487/10 , C07D405/14 , C07D487/08 , A61K31/497 , C07D491/107 , C07D241/18 , A61P35/00 , C07K16/28
摘要: Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号:US20190282576A1
公开(公告)日:2019-09-19
申请号:US16254333
申请日:2019-01-22
发明人: Evangelos Aktoudianakis , Gregory Chin , Richard L. Mackman , Samuel E. Metobo , Michael R. Mish , Hyung-Jung Pyun , Jeff Zablocki
IPC分类号: A61K31/517 , C07D471/04 , C07D239/84 , C07D401/04
摘要: The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D] pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.
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公开(公告)号:US10285990B2
公开(公告)日:2019-05-14
申请号:US15496283
申请日:2017-04-25
发明人: Evangelos Aktoudianakis , Gregory Chin , Richard L. Mackman , Samuel E. Metobo , Michael R. Mish , Hyung-Jung Pyun , Jeff Zablocki
IPC分类号: A61K31/517 , C07D471/04 , C07D239/84 , C07D401/04
摘要: The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D] pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.
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公开(公告)号:US20180327437A1
公开(公告)日:2018-11-15
申请号:US16011055
申请日:2018-06-18
发明人: Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang
CPC分类号: C07H1/00 , A61K31/7052 , A61K31/7056 , A61K31/706 , C07H19/23
摘要: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.
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公开(公告)号:US09670205B2
公开(公告)日:2017-06-06
申请号:US15059070
申请日:2016-03-02
发明人: Evangelos Aktoudianakis , Gregory Chin , Richard L. Mackman , Samuel E. Metobo , Michael R. Mish , Hyung-jung Pyun , Jeff Zablocki
IPC分类号: C07D471/04
CPC分类号: A61K31/517 , C07D239/84 , C07D401/04 , C07D471/04
摘要: The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D]pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.
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公开(公告)号:US20160031868A1
公开(公告)日:2016-02-04
申请号:US14774019
申请日:2014-03-27
发明人: Evangelos Aktoudianakis , Gregory Chin , Britton Kenneth Corkey , Jinfa Du , Kristyna Elbel , Robert H. Jiang , Tetsuya Kobayashi , Ruben Martinez , Samuel E. Metobo , Michael Mish , Sophie Shevick , David Sperandio , Hai Yang , Jeff Zablocki
IPC分类号: C07D413/14
CPC分类号: C07D413/14 , C07D413/04 , C07D417/14
摘要: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, and X are described herein.
摘要翻译: 本申请涉及可用作含溴结构域的蛋白质(包括含溴结构域蛋白质的蛋白质4(BRD4))的抑制剂或其它方式调节其含有活性的蛋白质的化学化合物,以及含有这些化合物的组合物和制剂,以及 使用和制造这些化合物。 化合物包括其中R1a,R1b,R2a,R2b,R3和X在本文中描述的式(I)的化合物。
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公开(公告)号:US20200017471A1
公开(公告)日:2020-01-16
申请号:US16510647
申请日:2019-07-12
发明人: Evangelos Aktoudianakis , Aesop Cho , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Devan Naduthambi , Barton W. Phillips , Scott Preston Simonovich , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC分类号: C07D401/14 , C07D471/08 , A61K39/395 , A61K31/704 , A61K31/7068 , A61K31/444 , A61K31/497
摘要: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号:US10442804B2
公开(公告)日:2019-10-15
申请号:US15885390
申请日:2018-01-31
发明人: Evangelos Aktoudianakis , Eda Canales , Kevin S. Currie , Darryl Kato , Jiayao Li , John O. Link , Samuel E. Metobo , Roland D. Saito , Scott D. Schroeder , Nathan Shapiro , Winston C. Tse , Qiaoyin Wu , Yunfeng Eric Hu
IPC分类号: C07D471/14 , C07D491/22 , C07D498/14 , C07D519/00 , A61P31/20 , C07B59/00
摘要: The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.
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公开(公告)号:US20190270727A1
公开(公告)日:2019-09-05
申请号:US16274106
申请日:2019-02-12
发明人: Evangelos Aktoudianakis , Aesop Cho , Zhimin Du , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Prasenjit Kumar Mukherjee , Devan Naduthambi , Eric Q. Parkhill , Barton W. Phillips , Scott Preston Simonovich , Neil H. Squires , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC分类号: C07D403/14 , A61P35/02 , A61P31/20 , C07D519/00 , A61K31/496
摘要: Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号:US20180305315A1
公开(公告)日:2018-10-25
申请号:US15957739
申请日:2018-04-19
发明人: Evangelos Aktoudianakis , Todd Appleby , Aesop Cho , Zhimin Du , Michael Graupe , Juan A. Guerrero , Salman Y. Jabri , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Prasenjit Kumar Mukherjee , Devan Naduthambi , Gregory Notte , Eric Q. Parkhill , Barton W. Phillips , Scott Preston Simonovich , Neil H. Squires , Chandrasekar Venkataramani , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC分类号: C07D213/69 , A61K45/06 , A61K31/444 , C07D401/14 , A61K31/4545 , C07D213/85 , A61K31/44 , C07D213/30 , C07D295/088 , A61K31/5377
CPC分类号: C07D213/69 , A61K31/44 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D213/30 , C07D213/61 , C07D213/64 , C07D213/85 , C07D295/088 , C07D401/04 , C07D401/14 , C07D405/14 , C07D487/08 , C07D487/10 , C07D491/107 , C07D498/04 , C07D519/00
摘要: Compounds according to formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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