公开(公告)号：US20170305910A1

公开(公告)日：2017-10-26

申请号：US15622838

申请日：2017-06-14

Applicant: Hydra Biosciences, Inc.

Inventor： Bertrand L. Chenard ,  Randall J. Gallaschun

IPC: C07D473/04 ,  C07D473/06 ,  C07D487/04 ,  C07D487/12

CPC classification number: C07D473/04 ,  C07D473/06 ,  C07D487/04 ,  C07D487/12

Abstract: Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.

公开(公告)号：US09440972B2

公开(公告)日：2016-09-13

申请号：US14822135

申请日：2015-08-10

Applicant: Hydra Biosciences, Inc.

Inventor： Bertrand L. Chenard ,  Randall J. Gallaschun

IPC: A61K31/519 ,  C07D471/04

CPC classification number: C07D471/04 ,  A61K31/519

Abstract: This invention relates to novel Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione derivatives of Formula (I): and their use as TRPC5 modulators, pharmaceutical compositions containing the same, and methods of using the same as agents for the treatment of TRPC5 receptor mediated disorders or conditions. R1, R2, R3 and R4 have meanings given in the description.

公开(公告)号：US09359359B2

公开(公告)日：2016-06-07

申请号：US14210781

申请日：2014-03-14

Applicant: Hydra Biosciences, Inc.

Inventor： Bertrand L. Chenard ,  Randall J. Gallaschun

IPC: C07D473/04 ,  C07D487/04 ,  C07D487/12

CPC classification number: C07D473/04 ,  C07D473/06 ,  C07D487/04 ,  C07D487/12

Abstract: Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.

Abstract translation: 描述了抑制TRPC5离子通道和与TRPC5相关的病症的化合物，组合物和方法。