公开(公告)号：US09186149B2

公开(公告)日：2015-11-17

申请号：US13271453

申请日：2011-10-12

申请人： Hancun Chen ,  Richard Murphy ,  Jimmy Dao

发明人： Hancun Chen ,  Richard Murphy ,  Jimmy Dao

IPC分类号： A61M29/00 ,  A61B17/12

CPC分类号： A61B17/12145 ,  A61B17/12031 ,  A61B17/12109 ,  A61B17/1215 ,  A61B17/1219 ,  A61B2017/12054 ,  A61B2017/12063

摘要： A vaso-occlusive device includes an inner coil made from inner coil wire having a first diameter and formed from a first material, and an outer coil disposed at least partially around the inner coil and made from outer coil wire having a second diameter and formed from a second material. The inner coil has a first pitch and the outer coil has a second pitch. The first diameter, material, and pitch are different from the second diameter, material, and pitch, respectively. The outer coil defines a lumen and the inner coil is disposed at least partially in the lumen. The vaso-occlusive device also includes an intermediate layer disposed between the inner coil and the outer coil, where the intermediate layer includes a biocompatible metal or a biocompatible, swellable polymer.

摘要翻译： 一种血管闭塞装置，包括由具有第一直径并由第一材料形成的内部线圈线制成的内部线圈，以及至少部分地围绕所述内部线圈设置并由具有第二直径的外部线圈线制成的外部线圈， 第二种材料。 内部线圈具有第一间距，外部线圈具有第二间距。 第一直径，材料和间距分别与第二直径，材料和间距不同。 外部线圈限定内腔，并且内部线圈至少部分地设置在内腔中。 血管闭塞装置还包括设置在内部线圈和外部线圈之间的中间层，其中中间层包括生物相容性金属或生物相容的可溶胀聚合物。

公开(公告)号：US08911814B2

公开(公告)日：2014-12-16

申请号：US12976695

申请日：2010-12-22

申请人： Hancun Chen

发明人： Hancun Chen

IPC分类号： A61L33/00 ,  A61M25/09

CPC分类号： A61M25/09

摘要： Medical devices and methods for making and using the same. An example medical device includes a slotted tubular member and a coating disposed over the tubular member. The coating may define one or more coating gaps therein.

摘要翻译： 医疗器械及其制造和使用方法。 示例性医疗装置包括开槽管状构件和设置在管状构件上方的涂层。 涂层可以在其中限定一个或多个涂层间隙。

公开(公告)号：US20120089174A1

公开(公告)日：2012-04-12

申请号：US13271453

申请日：2011-10-12

申请人： Hancun Chen ,  Richard Murphy ,  Jimmy Dao

发明人： Hancun Chen ,  Richard Murphy ,  Jimmy Dao

IPC分类号： A61F2/01

CPC分类号： A61B17/12145 ,  A61B17/12031 ,  A61B17/12109 ,  A61B17/1215 ,  A61B17/1219 ,  A61B2017/12054 ,  A61B2017/12063

摘要： A vaso-occlusive device includes an inner coil made from inner coil wire having a first diameter and formed from a first material, and an outer coil disposed at least partially around the inner coil and made from outer coil wire having a second diameter and formed from a second material. The inner coil has a first pitch and the outer coil has a second pitch. The first diameter, material, and pitch are different from the second diameter, material, and pitch, respectively. The outer coil defines a lumen and the inner coil is disposed at least partially in the lumen. The vaso-occlusive device also includes an intermediate layer disposed between the inner coil and the outer coil, where the intermediate layer includes a biocompatible metal or a biocompatible, swellable polymer.

摘要翻译： 一种血管闭塞装置，包括由具有第一直径并由第一材料形成的内部线圈线制成的内部线圈，以及至少部分地围绕所述内部线圈设置并由具有第二直径的外部线圈线制成的外部线圈， 第二种材料。 内部线圈具有第一间距，外部线圈具有第二间距。 第一直径，材料和间距分别与第二直径，材料和间距不同。 外部线圈限定内腔，并且内部线圈至少部分地设置在内腔中。 血管闭塞装置还包括设置在内部线圈和外部线圈之间的中间层，其中中间层包括生物相容性金属或生物相容的可溶胀聚合物。

公开(公告)号：US08137293B2

公开(公告)日：2012-03-20

申请号：US12620343

申请日：2009-11-17

申请人： Pu Zhou ,  Horng-Ban Lin ,  Hancun Chen ,  James Feng

发明人： Pu Zhou ,  Horng-Ban Lin ,  Hancun Chen ,  James Feng

IPC分类号： A61B5/00 ,  A61M25/00 ,  C22C28/00 ,  C22C19/05

CPC分类号： A61M25/09 ,  A61M2025/09083 ,  A61M2025/09133

摘要： Medical devices and methods for making and using the same are disclosed. An example medical device may include a guidewire. The guidewire may include an elongate shaft. The shaft may include a porous metal alloy. The porous metal alloy may be arranged so that the porous metal alloy has a first pore distribution along a first portion of the shaft and a second pore distribution different from the first pore distribution along a second portion of the shaft.

摘要翻译： 公开了用于制造和使用它们的医疗装置和方法。 示例性医疗设备可以包括导丝。 导丝可以包括细长轴。 轴可以包括多孔金属合金。 多孔金属合金可以布置成使得多孔金属合金沿着轴的第一部分具有第一孔分布，并且沿轴的第二部分具有不同于第一孔分布的第二孔分布。

公开(公告)号：US20110106128A1

公开(公告)日：2011-05-05

申请号：US12913177

申请日：2010-10-27

申请人： Hancun Chen

发明人： Hancun Chen

IPC分类号： A61M29/00

CPC分类号： A61B17/12022 ,  A61B17/12109 ,  A61B17/12145 ,  A61B17/1215 ,  A61B17/12154 ,  A61B2017/12063

摘要： A delivery wire assembly for delivering an occlusive device to a location in a patient's vasculature, includes delivery wire conduit defining a conduit lumen, a core wire disposed in the conduit lumen, the core wire having a distal detachment zone, and an enhancing coil disposed around the distal detachment zone, the enhancing coil configured to transfer a distally directed force from the delivery wire assembly to objects located distal of the delivery wire assembly without damaging the distal detachment zone. In one embodiment, the enhancing coil includes a proximal section having a first diameter, a distal section having a diameter larger than the diameter of the proximal section, and a transition section connecting the respective proximal and distal sections, wherein the transition section flares radially in a distal direction.

摘要翻译： 用于将闭塞装置输送到患者脉管系统中的位置的输送线组件包括限定导管腔的输送线导管，设置在导管管腔中的芯线，具有远端脱离区的芯线和围绕 所述远侧脱离区域，所述增强线圈构造成将远端指导的力从所述输送线组件传递到位于所述输送线组件远侧的物体，而不损坏所述远端脱离区。 在一个实施例中，增强线圈包括具有第一直径的近端部分，具有大于近端部分的直径的直径的远端部分和连接相应的近端部分和远端部分的过渡部分，其中过渡部分径向地以 远端方向。

公开(公告)号：US20110091639A1

公开(公告)日：2011-04-21

申请号：US12976695

申请日：2010-12-22

申请人： Hancun Chen

发明人： Hancun Chen

IPC分类号： B05D5/00 ,  B05D1/18 ,  B05D1/02

CPC分类号： A61M25/09

摘要： Medical devices and methods for making and using the same. An example medical device includes a slotted tubular member and a coating disposed over the tubular member. The coating may define one or more coating gaps therein.

摘要翻译： 医疗器械及其制造和使用方法。 示例性医疗装置包括开槽管状构件和设置在管状构件上方的涂层。 涂层可以在其中限定一个或多个涂层间隙。

公开(公告)号：US20100048758A1

公开(公告)日：2010-02-25

申请号：US12196771

申请日：2008-08-22

申请人： Hancun Chen ,  James G. Hansen

发明人： Hancun Chen ,  James G. Hansen

IPC分类号： A61K8/72 ,  B05D3/00

CPC分类号： A61L31/10 ,  A61L31/14 ,  C08L71/02 ,  C08L75/04

摘要： Alternative coating compositions and/or methods of coating a medical device. Some examples include coating compositions comprising a polyester urethane and a polyether in a substantially aqueous carrier. The coating composition may be provided as a one or two part system and may be applied by a variety of coating methods, in some cases without a requirement for special equipment or undue industrial hygiene concerns. Additionally, methods of coating medical devices with substantially aqueous coating compositions and the resulting coated medical devices. The composition may be applied to all or part of a medical device by spraying, dipping, brushing, extruding, or the like. After the coating composition has been applied, the substantially aqueous carrier, including any attendant cosolvents or other volatile species, may be removed, typically by heating with optional enhanced air flow although simple evaporation at ambient conditions may also be used.

摘要翻译： 替代的涂层组合物和/或涂覆医疗装置的方法。 一些实例包括在基本上水性载体中包含聚酯氨酯和聚醚的涂料组合物。 涂料组合物可以作为一个或两个部分系统提供，并且可以通过各种涂覆方法施用，在某些情况下不需要特殊设备或不适当的工业卫生关注。 另外，用基本上含水的涂料组合物涂覆医疗装置的方法以及所得的涂覆的医疗装置。 组合物可以通过喷涂，浸涂，刷涂，挤出等施用于医疗装置的全部或部分。 在施用涂料组合物之后，通常可以通过加热任选的增强空气流来除去基本上含水的载体，包括任何伴随的共溶剂或其它挥发性物质，尽管也可以使用在环境条件下简单的蒸发。

公开(公告)号：US08551020B2

公开(公告)日：2013-10-08

申请号：US11854954

申请日：2007-09-13

申请人： Hancun Chen ,  Horng-Ban Lin ,  Pu Zhou

发明人： Hancun Chen ,  Horng-Ban Lin ,  Pu Zhou

IPC分类号： A61M25/09

CPC分类号： A61M25/09 ,  A61M2025/09091 ,  A61M2025/09141 ,  A61M2025/0915

摘要： Medical devices and methods for manufacturing and using medical devices. An example medical device includes a core member, a tubular member coupled to the core member, and a tip member coupled to the tubular member. The tubular member may have a plurality of slots formed therein. The tip member may include a polymeric material. An intermediate member may be disposed between the tubular member and the core member that aids the bonding of the tip member thereto.

摘要翻译： 用于制造和使用医疗器械的医疗设备和方法。 一个示例性的医疗装置包括芯构件，联接到芯构件的管状构件和联接到管状构件的尖端构件。 管状构件可以具有形成在其中的多个槽。 尖端构件可以包括聚合物材料。 中间构件可以设置在管状构件和芯构件之间，其有助于尖端构件与其接合。

公开(公告)号：US20130066359A1

公开(公告)日：2013-03-14

申请号：US13608505

申请日：2012-09-10

申请人： Richard Murphy ,  Hancun Chen

发明人： Richard Murphy ,  Hancun Chen

IPC分类号： A61F2/01 ,  B21D31/00

CPC分类号： A61B17/12113 ,  A61B17/12145 ,  A61B17/1215

摘要： A vaso-occlusive device includes a coil made from coil wire, wherein the coil wire includes a core containing a core material having a first electrical potential covered by a coating containing a coating material having a second electrical potential, wherein the second electrical potential is less than the first electrical potential. A method of manufacturing a vaso-occlusive device includes cladding a core with a magnesium containing coating to form a wire, wrapping the wire around a mandrel to form a coil, and heat-setting the coiled wire. A method of occluding a body cavity with a vaso-occlusive device includes delivering the vaso-occlusive device to a body cavity and inducing a reduction reaction in the body cavity and adjacent the vaso-occlusive device, wherein the reduction reaction reduces infections and promotes cell proliferation in the body cavity.

摘要翻译： 一种血管闭塞装置包括由线圈线制成的线圈，其中所述线圈线包括芯，所述芯包含具有由包含具有第二电位的涂层材料的涂层覆盖的第一电位的芯材料，其中所述第二电势较小 比第一个电位。 制造血管闭塞装置的方法包括用含镁涂层包覆芯以形成线，将线围绕心轴缠绕以形成线圈，并对线圈进行热定型。 用血管闭塞装置闭塞体腔的方法包括将血管闭塞装置输送到体腔并在体腔内和邻近血管闭塞装置处引起还原反应，其中还原反应减少感染并促进细胞 体腔增生。

公开(公告)号：US20110118776A1

公开(公告)日：2011-05-19

申请号：US12945210

申请日：2010-11-12

申请人： Hancun Chen ,  Richard Murphy ,  Shana Castelli

发明人： Hancun Chen ,  Richard Murphy ,  Shana Castelli

IPC分类号： A61F2/01

CPC分类号： A61B17/12022 ,  A61B17/12031 ,  A61B17/12109 ,  A61B17/12145 ,  A61B17/1215 ,  A61B2017/00292 ,  A61B2017/00734 ,  A61B2017/12063

摘要： A delivery wire assembly for delivery of an occlusive device to a location in a patient's vasculature, the assembly having a distal end portion comprising a proximal rigid segment, a distal rigid segment, and a flexible segment disposed between the proximal and distal rigid segments. The assembly also has a delivery wire conduit having a proximal tubular portion coupled to a distal coil portion, the respective tubular and coil portions defining a conduit lumen. A plug is seated in the conduit lumen and secured to an interior surface of the delivery wire conduit. A core wire is disposed in the conduit lumen and having a distal end extending through the plug, so that the plug secures the core wire to the delivery wire conduit. The plug may form a substantially fluid tight seal of the conduit lumen.

摘要翻译： 用于将闭塞装置输送到患者脉管系统中的位置的输送线组件，所述组件具有包括近端刚性段，远侧刚性段和设置在近端和远端刚性段之间的柔性段的远端部分。 组件还具有输送线导管，其具有联接到远端线圈部分的近端管状部分，相应的管状部分和线圈部分限定导管腔。 塞子位于导管管腔中并固定到输送线管道的内表面。 芯线设置在导管管腔中并且具有延伸穿过插塞的远端，使得插头将芯线固定到输送线导管。 塞子可以形成导管管腔的基本上流体密封的密封。