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21.发明授权
公开(公告)号：US6155978A
公开(公告)日：2000-12-05
申请号：US210706
申请日：1998-12-09
CPC分类号： G01S7/52034 , G01S15/8993 , G01S7/52026 , Y10S128/916
摘要： In three-dimensional imaging of ultrasound data, speckle artifact data are reduced before the acquired data from a volume of interest are projected onto an image plane. A master controller performs an algorithm that iteratively morphologically filters the pixel data in a volume of interest and then iteratively projects the morphologically filtered data onto a plurality of rotated image planes using a ray-casting technique. Morphological filtering is performed by stepping a seven-point kernel through a source data volume of pixel data. The kernel, made up of a central pixel value and the six pixel values adjacent to the central pixel value, is stepped through the entire source data volume. The morphological filtering operation includes at least one erosion step, which removes speckle, followed by an equal number of dilation steps, which restore the imaging data.
摘要翻译： 在超声数据的三维成像中，在将来自感兴趣体积的所获取的数据投影到图像平面上之前，斑点伪影数据被减少。 主控制器执行迭代地形态地过滤感兴趣体积中的像素数据的算法，然后使用射线投射技术将形态滤波的数据迭代地投影到多个旋转图像平面上。 通过对像素数据的源数据量进行七点内核进行形态滤波。 由中心像素值构成的内核和与中心像素值相邻的六个像素值，跨越整个源数据量。 形态学过滤操作包括至少一个侵蚀步骤，其消除斑点，随后是等量的扩张步骤，其恢复成像数据。
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公开(公告)号：US5821942A
公开(公告)日：1998-10-13
申请号：US622639
申请日：1996-03-27
摘要： A system for displaying sets of surface cubes with gradient vertex vectors first employs a pointer table constructed to order the surface cubes so as to generally cause a row by row and layer by layer ordering during model creation. During display, a viewpoint is selected and a scan controller causes cubes to be displayed according to this order of the pointer table. A test backprojection of cubes to image plane is performed to determine which pixels will be impinged by the cubes. For pixels which have not been updated, or pixels which have been updated by a less superficial cube than the current cube, projection rays are created through the center of impinged pixels in a direction opposite that of the backprojection. An intersection point of the ray with a surface within a current cube is determined. The data value and gradient vectors for the current cube are interpolated at this intersection point. These interpolated vector and value are then rendered to produce and image with less distortion and with less processing complexity.
摘要翻译： 用于显示具有渐变顶点向量的表面立方体的集合的系统首先采用构造成对表面立方体进行排序的指针表，以便在模型创建期间通常逐行并逐层排序。 在显示期间，选择视点，并且扫描控制器根据指针表的顺序使多维数据集显示。 执行立方体到图像平面的测试反投影以确定哪些像素将被立方体撞击。 对于尚未更新的像素，或者由比当前立方体更少的表面立方体更新的像素，通过与背投影相反的方向通过撞击像素的中心创建投影光线。 确定射线与当前立方体内的表面的交点。 在该交点处插入当前立方体的数据值和梯度向量。 然后渲染这些内插向量和值以产生和图像，具有较少的失真和较少的处理复杂度。
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公开(公告)号：US08031924B2
公开(公告)日：2011-10-04
申请号：US11948205
申请日：2007-11-30
申请人： Ali Can , Michael John Gerdes , Harvey Ellis Cline
发明人： Ali Can , Michael John Gerdes , Harvey Ellis Cline
IPC分类号： G06K9/00
CPC分类号： G01N21/6458 , G01N21/6428 , G01N2021/6441
摘要： Method and systems for removing any inherent autofluorescence associated with a biological material, comprising: acquiring a first reference image of the biological material; acquiring a first set of one or more images of the biological material using one or more filters corresponding to one or more information dyes; applying the one or more additional dyes to the biological material and then acquiring a second set of one or more images comprising a separate image of the biological material with each of the filters corresponding to the information dyes and a second reference image of the biological material; coregistering the first and second reference images; and then removing any inherent autofluorescence exhibited in the informational images acquired.
摘要翻译： 用于去除与生物材料相关联的任何固有自发荧光的方法和系统，包括：获取所述生物材料的第一参考图像; 使用对应于一种或多种信息染料的一个或多个过滤器获取所述生物材料的第一组一个或多个图像; 将一种或多种另外的染料施加到生物材料上，然后获取包含生物材料的单独图像的第二组一个或多个图像，其中每个滤色器对应于信息染料和生物材料的第二参考图像; 整合第一和第二参考图像; 然后去除所获得的信息图像中显示的任何固有自发荧光。
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24.发明申请System and method for co-registering multi-channel images of a tissue micro array 有权用于共同记录组织微阵列的多通道图像的系统和方法公开(公告)号：US20080032328A1
公开(公告)日：2008-02-07
申请号：US11500028
申请日：2006-08-07
申请人： Harvey Ellis Cline , Ali Can
发明人： Harvey Ellis Cline , Ali Can
CPC分类号： G01N1/30 , G06T7/35 , G06T2207/30024 , G06T2207/30072
摘要： A system and methods for co-registering multi-channel images of a tissue micro array, comprising the steps of, providing a biological material on a substrate; applying one or more molecular probes, adapted to provide fluorescent molecular markers, to the biological material; obtaining a first digital image of the biological material and the fluorescent molecular markers; applying a morphological stain to the biological material; obtaining a second digital image of the biological material, computing information common to the first and second images; and co-registering the second image with the first image based on one or more registration metrics.
摘要翻译： 一种用于共同配准组织微阵列的多通道图像的系统和方法，包括以下步骤：在基底上提供生物材料; 将一种或多种适于提供荧光分子标记的分子探针应用于生物材料; 获得生物材料和荧光分子标记物的第一数字图像; 对生物材料施加形态染色; 获得生物材料的第二数字图像，计算第一和第二图像共同的信息; 以及基于一个或多个注册度量与所述第一图像共同配准所述第二图像。
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公开(公告)号：US06978039B2
公开(公告)日：2005-12-20
申请号：US09683321
申请日：2001-12-13
申请人： Harvey Ellis Cline , Siegwalt Ludke
发明人： Harvey Ellis Cline , Siegwalt Ludke
CPC分类号： G06T7/0012 , G06T7/11 , G06T7/168 , G06T7/187 , G06T2207/10072 , G06T2207/20064 , G06T2207/20101 , G06T2207/30004 , Y10S128/922
摘要： A method and system for segmenting three-dimensional (3D) medical images containing an object of interest are provided. The method comprises generating a plurality of successive layers of fixed radius spheres about a circumference of a sphere containing at least one seed point placed within the object of interest when a plurality of respective voxels contained within the spheres exceed a selected threshold. The generation of the layers is repeated until no further voxels contained within an outer surface of each respective layer exceed the selected threshold or a stop seed point is encountered. The layers form a segmented representation of the object of interest.
摘要翻译： 提供了一种用于分割包含感兴趣对象的三维（3D）医学图像的方法和系统。 该方法包括当包含在球体内的多个相应体素超过所选择的阈值时，围绕包含放置在感兴趣对象内的至少一个种子点的球体的圆周周围生成多个连续的固定半径球体层。 重复层的产生，直到每个相应层的外表面中包含的进一步体素超过所选择的阈值或遇到停止种子点。 层形成感兴趣对象的分段表示。
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26.发明授权公开(公告)号：US06539074B1
公开(公告)日：2003-03-25
申请号：US09648957
申请日：2000-08-25
申请人： Mehmet Yavuz , Harvey Ellis Cline
发明人： Mehmet Yavuz , Harvey Ellis Cline
IPC分类号： A61B603
CPC分类号： A61B6/541 , A61B5/7289 , A61B5/7292 , A61B6/027 , A61B6/032 , A61B6/4085 , A61B6/503 , A61B6/508 , Y10S378/901
摘要： The invention provides tomographic image generation from four-dimensional projection data of an imaged object. The ability is provided to extract implicit information from time dependent aspects of volumetric projection data corresponding to multiple data acquisition cycles. The result is improved volumetric image quality from volumetric projection data previously used for slice by slice image reconstruction. The invention provides particular advantages for volumetric imaging of a patient's heart, or a portion thereof, at a selected phase of the cardiac cycle.
摘要翻译： 本发明提供从成像对象的四维投影数据生成断层图像。 提供了从与多个数据采集周期对应的体积投影数据的时间相关方面提取隐含信息的能力。 结果是从先前用于逐层图像重建的体积投影数据改善了体积图像质量。 本发明为心脏周期的选定阶段的患者心脏或其一部分的体积成像提供了特定的优点。
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27.发明授权公开(公告)号：US06438403B1
公开(公告)日：2002-08-20
申请号：US09431949
申请日：1999-11-01
申请人： Harvey Ellis Cline , Siegwalt Ludke
发明人： Harvey Ellis Cline , Siegwalt Ludke
IPC分类号： A61B505
CPC分类号： G06T17/00 , G06T7/0012 , G06T7/11 , G06T2207/10072 , G06T2207/20156 , G06T2207/30048
摘要： An imaging system enables cardiac functioning within a particular cardiac chamber to be imaged. The system acquires imaging data that includes intensity values for four-dimensional voxels within a region of interest (ROI). A seed voxel is identified, and neighbor voxels to the seed voxel are also identified. The intensity values for each neighbor voxel are compared to a threshold to determine whether the voxel corresponds to blood or muscle tissue. For each neighbor voxel corresponding to blood, its neighbor voxels are identified and compared to the threshold, and this process is repeated until a pre-established spatial boundary is encountered or the number of new neighbor voxels indicates that processing is migrating into an adjacent cardiac chamber. At that point, the identified blood voxels are counted into bins of cardiac phases, cardiac images for each phase are reconstructed, and parameters such as ejection fraction are calculated.
摘要翻译： 成像系统使得能够对特定心室内的心脏功能进行成像。 该系统获取包括感兴趣区域（ROI）内的四维体素的强度值的成像数据。 识别种子体素，并且还识别出种子体素的相邻体素。 将每个邻近体元的强度值与阈值进行比较，以确定体素是否对应于血液或肌肉组织。 对于对应于血液的每个邻近体素，其邻近体素被识别并与阈值进行比较，并且重复该过程直到遇到预先建立的空间边界或新邻居体素的数目表示该过程迁移到相邻心室 。 在这一点上，将识别的血液体素计数为心脏相的心脏区，重建每个阶段的心脏图像，并计算诸如射血分数的参数。
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公开(公告)号：US06281681B1
公开(公告)日：2001-08-28
申请号：US09336580
申请日：1999-06-21
IPC分类号： A61B5055
摘要： An MRI system is employed to acquire image data using a pulse sequence in which k-space is sampled in a Fibonacci spiral trajectory. A single pulse sequence may be used to sample all of k-space with a single spiral arm, or k-space can be sampled with a plurality of interleaved Fibonacci spiral arms by performing a corresponding series of pulse sequences.
摘要翻译： 使用MRI系统来采用在斐波那契螺旋轨迹中采样k空间的脉冲序列来获取图像数据。 可以使用单个脉冲序列用单个螺旋臂对所有k空间进行采样，或者可以通过执行相应的一系列脉冲序列，用多个交织的斐波纳契螺旋臂对k空间进行采样。
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公开(公告)号：US5900880A
公开(公告)日：1999-05-04
申请号：US613811
申请日：1996-03-06
CPC分类号： G06T17/00
摘要： A system for display of interfaces within a block of raw data values comprises a model building portion groups data points into a cubes, receives a threshold and identifies cubes which a vertex data values which straddle the threshold. These are surface cubes. Gradient vectors for each vertex of each cube are determined by comparing the change in data values in three dimensions in a neighborhood around each vertex. The surface cubes and their associated gradient vectors are stored as a cube/vector model. his model may be tessellated and then displayed by conventional CAD/CAM workstations. A second display system is shown which employs a modified "Dividing Cubes" method to subdivide the cubes, interpolate each to a center point and associated vector, then backprojected to produce perspective.
摘要翻译： 用于显示原始数据值块内的接口的系统包括模型构建部分将数据点分组成多维数据集，接收阈值并识别跨越阈值的顶点数据值的多维数据集。 这些是表面立方体。 通过比较每个顶点附近的三维数据值的变化来确定每个立方体的每个顶点的渐变矢量。 表面立方体及其相关的梯度向量存储为立方体/向量模型。 他的模型可能是细分的，然后由传统的CAD / CAM工作站显示。 示出了第二显示系统，其采用修改的“分割立方体”方法来细分立方体，将每一个内插到中心点和相关联的向量，然后反向投影以产生透视图。
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30.发明授权Visualization of a multi-dimensional data set acquired with a surface receive coil 失效用表面接收线圈获取的多维数据集的可视化
公开(公告)号：US5659629A
公开(公告)日：1997-08-19
申请号：US419072
申请日：1995-04-07
申请人： Harvey Ellis Cline
发明人： Harvey Ellis Cline
CPC分类号： G06T7/0083 , G01R33/5659 , G06T5/009 , G06T5/40 , G01R33/5608 , G06T2207/10088 , G06T2207/20092
摘要： A multi-dimensional data set acquired by non-intrusive means with the use of a surface coil of internal structures of internal structures of a subject. The data set is adjusted for the differential sensitivity of the surface coil with respect to distance from the coil and angle in relation to the coil. The adjusted data set then is searched for abrupt changes in value in the data set indicating surfaces. The surfaces then may be manipulated, shaded, color coded and displayed. This is particularly useful in when employed on a data set which images blood for providing surface images of coronary arteries of the subject for non-invasive detection of occlusion and stenosis.
摘要翻译： 通过使用受试者的内部结构的内部结构的表面线圈的非侵入性手段获得的多维数据集。 根据与线圈的距离和相对于线圈的角度，调整表面线圈的差分灵敏度的数据组。 然后搜索经调整的数据集，以便数据集指示表面中的值突然变化。 然后可以对表面进行操作，阴影，颜色编码和显示。 当用于图像用于提供受试者的冠状动脉的表面图像的血液用于非侵入性检测闭塞和狭窄的数据集时，这是特别有用的。
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