公开(公告)号：US20060182799A1

公开(公告)日：2006-08-17

申请号：US10501873

申请日：2003-01-21

申请人： Jari Alander ,  Staffan Norberg ,  Henri Hansson ,  Marianne Svard ,  Lars Hovgaard

发明人： Jari Alander ,  Staffan Norberg ,  Henri Hansson ,  Marianne Svard ,  Lars Hovgaard

IPC分类号： A61K9/20 ,  B27N3/02

CPC分类号： A61K9/1617 ,  A61K9/1075 ,  A61K9/1274 ,  A61K9/1694 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027

摘要： The invention refers to a process for the preparation of a self-dispersing or self-emulsifying tablet, wherein a heated granulation mixture containing an active lipophilic substance and a surfactant is granulated into granules, said granules are cooled to a semi-solid state, said semi-solid granules are mixed with one or more fillers to cover the surface of the granules, distribution, the sieved granules are mixed with tabletting aids, and said mixture is compressed into tablets. The granulation mixture can also contain a lipid and/or filler. The invention also refers to tablets prepared by said processes.

摘要翻译： 本发明涉及一种制备自分散或自乳化片剂的方法，其中将含有活性亲脂性物质和表面活性剂的加热的造粒混合物造粒成颗粒，将所述颗粒冷却至半固体状态，所述 将半固体颗粒与一种或多种填料混合以覆盖颗粒的表面，分布，将筛分的颗粒与压片助剂混合，并将所述混合物压制成片剂。 造粒混合物还可以含有脂质和/或填料。 本发明还涉及通过所述方法制备的片剂。

公开(公告)号：US20050061339A1

公开(公告)日：2005-03-24

申请号：US10499552

申请日：2002-12-17

申请人： Henri Hansson ,  Lars Hovgaard ,  Christer Spegel

发明人： Henri Hansson ,  Lars Hovgaard ,  Christer Spegel

IPC分类号： A24B13/00 ,  A24B15/16 ,  A24B15/00

CPC分类号： A24B13/00 ,  A24B15/16

摘要： A novel composition for the use as snuff in the oral cavity, the composition comprising tobacco and/or a tobacco substitute encapsulated in a membrane material comprising one or more membranes at least one of which being water permeable and water-insoluble. A novel composition enables a selective release of e.g. nicotine while it at the same time reduces the release of substances, which normally lead to unwanted side effects. The novel compositions may be used as a healthier alternative to snuff and other tobacco products such as, e.g., cigarettes, cigars and pipe. Methods for giving up smoking, reducing nicotine craving, reducing side effects normally related to smoking and snuffing of tobacco as welt a method for the preparation of a composition according to the invention.

摘要翻译： 一种用于在口腔中用作鼻烟的新型组合物，该组合物包含封装在膜材料中的烟草和/或烟草替代物，其包含一种或多种膜，其中至少一种是透水性和水不溶性的膜。 一种新型组合物可以选择性释放例如 尼古丁同时减少物质的释放，这通常会导致不必要的副作用。 该新型组合物可用作鼻烟和其它烟草制品例如香烟，雪茄和管子的更健康的替代品。 放弃吸烟的方法，减少尼古丁渴望，减少通常与烟草吸烟和窒息相关的副作用，这是制备根据本发明的组合物的方法。