公开(公告)号：US20120035167A1

公开(公告)日：2012-02-09

申请号：US13131360

申请日：2009-11-24

申请人： Jose Maria Cid-Nunez ,  Andres Avelino Trabanco-Suarez ,  Gregor James Macdonald

发明人： Jose Maria Cid-Nunez ,  Andres Avelino Trabanco-Suarez ,  Gregor James Macdonald

IPC分类号： A61K31/538 ,  A61K31/437 ,  A61K31/506 ,  A61P25/00 ,  A61P25/22 ,  A61P25/16 ,  A61P25/06 ,  A61P25/08 ,  A61P25/28 ,  A61P25/30 ,  A61P25/32 ,  A61P25/12 ,  C07D471/04 ,  A61P25/18

CPC分类号： C07D265/36

摘要： The present invention relates to novel indole and benzoxazine derivatives which are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (“mGluR2”) and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds for the prevention or treatment of neurological and psychiatric disorders and diseases in which mGluR2 is involved.

摘要翻译： 本发明涉及新的吲哚和苯并恶嗪衍生物，其是代谢型谷氨酸受体亚型2（“mGluR2”）的正性变构调节剂，其可用于治疗或预防与谷氨酸能力障碍相关的神经和精神障碍及其中 涉及代谢型受体的mGluR2亚型。 本发明还涉及包含这种化合物的药物组合物，制备这些化合物和组合物的方法，以及这些化合物用于预防或治疗其中涉及mGluR2的神经和精神疾病和疾病的用途。

公开(公告)号：US20110269752A1

公开(公告)日：2011-11-03

申请号：US13096545

申请日：2011-04-28

申请人： Joaquin Pastor-Fernández ,  José Manuel Bartolomé-Nebreda ,  Gregor James Macdonald ,  Susana Conde-Ceide ,  Óscar Delgado-González ,  Greta Constantia Peter Vanhoof ,  Michiel Luc Maria Van Gool ,  María Luz Martin-Martín ,  Sergio-Alvar Alonso-de Diego ,  Kelly Ann Swinney ,  Carina Leys ,  Johan Erwin Edmond Weerts ,  Stijn Wuyts

发明人： Joaquin Pastor-Fernández ,  José Manuel Bartolomé-Nebreda ,  Gregor James Macdonald ,  Susana Conde-Ceide ,  Óscar Delgado-González ,  Greta Constantia Peter Vanhoof ,  Michiel Luc Maria Van Gool ,  María Luz Martin-Martín ,  Sergio-Alvar Alonso-de Diego ,  Kelly Ann Swinney ,  Carina Leys ,  Johan Erwin Edmond Weerts ,  Stijn Wuyts

IPC分类号： A61K31/5377 ,  C07D471/04 ,  A61K31/5025 ,  A61P25/18 ,  A61P3/00 ,  A61P25/14 ,  A61P25/28 ,  A61P25/30 ,  A61P25/00 ,  C07D413/14 ,  A61P25/22

CPC分类号： C07D487/04

摘要： The present invention relates to novel imidazo[1,2-b]pyridazine derivatives which are inhibitors of the phosphodiesterase 10 enzyme (PDE10) and which are useful for the treatment or prevention of neurological, psychiatric and metabolic disorders in which the PDE10 enzyme is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, to the use of such compounds or pharmaceutical compositions for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases.

摘要翻译： 本发明涉及作为磷酸二酯酶10酶（PDE10）的抑制剂的新的咪唑并[1,2-b]哒嗪衍生物，它们可用于治疗或预防涉及PDE10酶的神经，精神和代谢紊乱 。 本发明还涉及包含这些化合物的药物组合物，以制备这些化合物和组合物以使用这些化合物或药物组合物来预防或治疗神经，精神和代谢疾病和疾病。

公开(公告)号：US07452888B2

公开(公告)日：2008-11-18

申请号：US10509078

申请日：2003-03-25

申请人： Mahmood Ahmed ,  Christopher Norbert Johnson ,  Martin C Jones ,  Gregor James Macdonald ,  Stephen Frederick Moss ,  Mervyn Thompson ,  Charles Edward Wade ,  David R Witty

发明人： Mahmood Ahmed ,  Christopher Norbert Johnson ,  Martin C Jones ,  Gregor James Macdonald ,  Stephen Frederick Moss ,  Mervyn Thompson ,  Charles Edward Wade ,  David R Witty

IPC分类号： A61K31/496 ,  C07D215/40

CPC分类号： C07D487/04 ,  C07D215/00 ,  C07D487/08

摘要： Disclosed are novel quinoline compounds of formula (I), processes for their preparation, compositions containing them and their use in the treatment of CNS disorders.

摘要翻译： 公开了式（I）的新型喹啉化合物，其制备方法，含有它们的组合物及其在治疗CNS障碍中的用途。