公开(公告)号：US06630156B1

公开(公告)日：2003-10-07

申请号：US09762984

申请日：2001-04-23

申请人： Min Hyo Seo ,  Jae Yong Lee ,  Jee Hyang Kim

发明人： Min Hyo Seo ,  Jae Yong Lee ,  Jee Hyang Kim

IPC分类号： A61F200

CPC分类号： A61K9/5031 ,  A61K9/5089

摘要： The present invention relates to a process for preparing biodegradable microspheres containing physiologically active agents. Particularly, the present invention relates to the process comprised the following steps (1) to prepare a polymer solution containing physiologically active agents wherein a biodegradable polymer is dissolved in a water-soluble organic solvent and physiologically active agents are dissolved or suspended to it; (2) to form a O/O type emulsion by emulsifying the polymer solution into a water soluble alcohol which contains an emulsion stabilizer; and (3) to extract the organic solventS and alcohol by adding the emulsion into a neutral or an alkaline aqueous solution to educe the microspheres. The process of the present invention is effective for producing the microspheres having a uniform size which arm congenital to a living body and has an excellent inclusion efficiency. So, the microspheres prepared by the process of the present invention are used for a drug delivery system.

摘要翻译： 本发明涉及一种制备含有生理活性剂的可生物降解的微球的方法。 特别地，本发明涉及制备含有生物降解性聚合物溶解在水溶性有机溶剂中的生理活性剂的聚合物溶液和生理活性剂溶解或悬浮的方法的步骤（1） （2）通过将聚合物溶液乳化成含有乳液稳定剂的水溶性醇形成O / O型乳液; 和（3）通过将乳液加入到中性或碱性水溶液中以引发微球体来萃取有机溶剂和醇。 本发明的方法对于生产具有均一尺寸的微生物有效用于生物体先天性并且具有优异的包合效率。 因此，通过本发明的方法制备的微球体用于药物递送系统。