利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

67 条记录 (耗时 0.032 秒)

    Long acting beta-2-agonists and their use as medicaments
    23.
    发明申请
    Long acting beta-2-agonists and their use as medicaments 有权

    公开(公告)号：US20070066609A1

    公开(公告)日：2007-03-22

    申请号：US11600417

    申请日：2006-11-15

    申请人： Thierry Bouyssou ,  Ingo Konetzki ,  Philipp Lustenberger ,  Juergen Mack ,  Andreas Schnapp ,  Dieter Wiedenmayer ,  Christoph Hoenike ,  Klaus Rudolf

    发明人： Thierry Bouyssou ,  Ingo Konetzki ,  Philipp Lustenberger ,  Juergen Mack ,  Andreas Schnapp ,  Dieter Wiedenmayer ,  Christoph Hoenike ,  Klaus Rudolf

    IPC分类号： A61K31/538 ,  C07D413/02

    CPC分类号： C07D265/36 ,  C07D413/12

    摘要： A compound of formula 1′ wherein: V is —CH2—, —NH—, or —O—; Ra and Rb are each independently hydrogen, C1-4-alkyl, or halogen-C1-4-alkyl, or Ra and Rb together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R1 and R1′ are each independently hydrogen, C1-6-alkyl, C3-6-cycloalkyl, halogen-C1-6-alkyl, halogen-C3-6-cycloalkyl, or C1-6-alkylene-C3-6-cycloalkyl, or R1 and R1′ together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R2, R2′, R2″, and R′″ are each independently hydrogen, C1-6-alkyl, halogen-C1-6-alkylene, OH, HO—C1-6-alkylene, —O—C1-6-alkyl, C6-10-aryl, C6-10-aryl-C1-4-alkylene, C6-10-aryl-C1-6-alkylene-O, COOH, COOC1-6-alkyl, O—C1-6-alkylene-COOH, O—C1-6-alkylene-COOC1-6-alkyl, NHSO2—C1-6-alkyl, CN, NH2, NH—C1-6-alkyl, N(C1-6-alkyl)2, NO2, S—C1-6-alkyl, SO2—C1-6-alkyl, SO—C1-6-alkyl, O(CO)C1-6-alkyl, COC1-6-alkyl, NHCOC1-6-alkyl, or halogen; and n is 0, 1, or 2, or an optical isomer thereof, or a corresponding acid addition salt thereof with a pharmacologically acceptable acid, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.