公开(公告)号：US20070048222A1

公开(公告)日：2007-03-01

申请号：US11553821

申请日：2006-10-27

申请人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

发明人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

IPC分类号： A61K51/00 ,  A61K39/395 ,  C07K16/28 ,  C07K16/46

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20070140964A1

公开(公告)日：2007-06-21

申请号：US11553241

申请日：2006-10-26

申请人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

发明人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

IPC分类号： A61K51/00 ,  A61K39/395 ,  A61K38/17

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20070049530A1

公开(公告)日：2007-03-01

申请号：US11552653

申请日：2006-10-25

申请人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

发明人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

IPC分类号： A61K38/17 ,  C07K14/705 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20070048834A1

公开(公告)日：2007-03-01

申请号：US11552710

申请日：2006-10-25

申请人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

发明人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

IPC分类号： C12P21/06 ,  C07H21/04 ,  C07K14/715

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20060141579A1

公开(公告)日：2006-06-29

申请号：US11301764

申请日：2005-12-13

申请人： Cindy Sprecher ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

发明人： Cindy Sprecher ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

IPC分类号： C12P21/02 ,  C07H21/04 ,  C07K14/52

CPC分类号： C07K16/24 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/52 ,  C07K2317/24

摘要： The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

摘要翻译： 本发明涉及zcytor17lig多核苷酸，多肽和抗zcytor17抗体分子。 zcytor17lig是一种新型细胞因子。 多肽可用于刺激免疫系统的方法，体外和体内造血细胞的增殖和/或发育。 本发明还包括生产蛋白质的方法，用途及其抗体。

公开(公告)号：US20070048832A1

公开(公告)日：2007-03-01

申请号：US11552647

申请日：2006-10-25

申请人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dollon

发明人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dollon

IPC分类号： C12P21/06 ,  C07H21/04 ,  C07K14/715

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

摘要翻译： 公开了新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，用于含有Zcytor17的多聚体或异二聚体细胞因子受体，其可用作新的细胞因子拮抗剂，并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ，淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法，其用途及其抗体。

公开(公告)号：US20070224118A1

公开(公告)日：2007-09-27

申请号：US11538350

申请日：2006-10-03

申请人： Cindy Sprecher ,  Julia Novak ,  James West ,  Scott Presnell ,  Richard Holly ,  Andrew Nelson

发明人： Cindy Sprecher ,  Julia Novak ,  James West ,  Scott Presnell ,  Richard Holly ,  Andrew Nelson

IPC分类号： A61K39/395

CPC分类号： C07K16/2866 ,  A61K38/00 ,  C07K14/7155 ,  C07K2317/73 ,  C07K2319/00

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block zalpha11 Ligand activity in vitro and in vivo, and may be used in conjunction with zalpha11 Ligand and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

摘要翻译： 公开了可用作新型细胞因子拮抗剂的可溶性zalpha11受体的新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，以及用于检测刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法 体外和体内。 配体结合受体多肽也可用于在体外和体内阻断zalpha11配体活性，并可与zalpha11配体和其他细胞因子结合使用以选择性刺激免疫系统。 本发明还包括生产蛋白质的方法，用途及其抗体。

公开(公告)号：US20070249020A1

公开(公告)日：2007-10-25

申请号：US11609499

申请日：2006-12-12

申请人： Cindy Sprecher ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Angela Hammond ,  Jane Gross

发明人： Cindy Sprecher ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Angela Hammond ,  Jane Gross

IPC分类号： C12P21/02 ,  C07H21/04 ,  C07K14/52

CPC分类号： C07K16/24 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/52 ,  C07K2317/24

摘要： The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

摘要翻译： 本发明涉及zcytor17lig多核苷酸，多肽和抗zcytor17抗体分子。 zcytor17lig是一种新型细胞因子。 多肽可用于刺激免疫系统的方法，体外和体内造血细胞的增殖和/或发育。 本发明还包括生产蛋白质的方法，用途及其抗体。

公开(公告)号：US20070077627A1

公开(公告)日：2007-04-05

申请号：US11610126

申请日：2006-12-13

申请人： Cindy Sprecher ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Angela Hammond ,  Jane Gross

发明人： Cindy Sprecher ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Angela Hammond ,  Jane Gross

IPC分类号： C07K14/52 ,  C07H21/04 ,  C12P21/02

CPC分类号： C07K16/24 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/52 ,  C07K2317/24

摘要： The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

摘要翻译： 本发明涉及zcytor17lig多核苷酸，多肽和抗zcytor17抗体分子。 zcytor17lig是一种新型细胞因子。 多肽可用于刺激免疫系统的方法，体外和体内造血细胞的增殖和/或发育。 本发明还包括生产蛋白质的方法，用途及其抗体。

公开(公告)号：US20060269551A1

公开(公告)日：2006-11-30

申请号：US11458666

申请日：2006-07-19

申请人： Penny Thompson ,  Donald Foster ,  Wenfeng Xu ,  Karen Madden ,  James Kelly ,  Cindy Sprecher ,  Hal Blumberg ,  Maribeth Eagan ,  Stephen Jaspers ,  Yasmin Chandrasekher ,  Julia Novak

发明人： Penny Thompson ,  Donald Foster ,  Wenfeng Xu ,  Karen Madden ,  James Kelly ,  Cindy Sprecher ,  Hal Blumberg ,  Maribeth Eagan ,  Stephen Jaspers ,  Yasmin Chandrasekher ,  Julia Novak

IPC分类号： A61K39/395 ,  A61K38/13 ,  A61K31/59 ,  A61K31/573 ,  A61K31/366 ,  A61K31/525 ,  A61K31/20 ,  A61K31/07 ,  A61K31/203

CPC分类号： C07K16/244 ,  A61K31/07 ,  A61K31/20 ,  A61K31/203 ,  A61K31/366 ,  A61K31/519 ,  A61K31/525 ,  A61K31/573 ,  A61K31/59 ,  A61K38/13 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  C07K14/7155 ,  C07K16/2887 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S514/886 ,  A61K2300/00

摘要： A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult respiratory disease, psoriasis, eczema, contact dermatitis, atopic dermatitis, septic shock, multiple organ failure, inflammatory lung injury, bacterial pneumonia, inflammatory bowel disease, rheumatoid arthritis, asthma, ulcerative colitis and Crohn's disease.