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    Polymers for metal extractions in carbon dioxide
    21.
    发明授权
    Polymers for metal extractions in carbon dioxide 失效
    用于二氧化碳中金属萃取的聚合物

    公开(公告)号：US06176895B1

    公开(公告)日：2001-01-23

    申请号：US09185891

    申请日：1998-11-04

    申请人： Joseph M. DeSimone ,  William Tumas ,  Kimberly R. Powell ,  T. Mark McCleskey ,  Timothy J. Romack ,  James B. McClain ,  Eva R. Birnbaum

    发明人： Joseph M. DeSimone ,  William Tumas ,  Kimberly R. Powell ,  T. Mark McCleskey ,  Timothy J. Romack ,  James B. McClain ,  Eva R. Birnbaum

    IPC分类号： C22B326

    CPC分类号： C22B3/0005 ,  C22B3/0097 ,  Y02P10/234

    摘要： A composition useful for the extraction of metals and metalloids comprises (a) carbon dioxide fluid (preferably liquid or supercritical carbon dioxide); and (b) a polymer in the carbon dioxide, the polymer having bound thereto a ligand that binds the metal or metalloid; with the ligand bound to the polymer at a plurality of locations along the chain length thereof (i.e., a plurality of ligands are bound at a plurality of locations along the chain length of the polymer). The polymer is preferably a copolymer, and the polymer is preferably a fluoropolymer such as a fluoroacrylate polymer. The extraction method comprises the steps of contacting a first composition containing a metal or metalloid to be extracted with a second composition, the second composition being as described above; and then extracting the metal or metalloid from the first composition into the second composition.

    摘要翻译： 用于萃取金属和准金属的组合物包括（a）二氧化碳流体（优选液体或超临界二氧化碳）; 和（b）二氧化碳中的聚合物，所述聚合物结合有与金属或准金属结合的配体; 其中配体在其长度的多个位置处与聚合物结合（即，多个配体沿聚合物链长度的多个位置结合）。 聚合物优选为共聚物，聚合物优选为氟聚合物，例如氟代丙烯酸酯聚合物。 提取方法包括以下步骤：将含有待萃取的金属或准金属的第一组合物与第二组合物接触，第二组合物如上所述; 然后将金属或准金属从第一组合物提取到第二组合物中。

    DRUG DELIVERY MEDICAL DEVICE
    27.
    发明申请
    DRUG DELIVERY MEDICAL DEVICE 审中-公开
    药物递送医疗设备

    公开(公告)号：US20130172853A1

    公开(公告)日：2013-07-04

    申请号：US13809324

    申请日：2011-07-15

    申请人： James B. McClain ,  Charles Douglas Taylor ,  Brett G. Zani ,  John Neet ,  Timothy Charles Kiorpes

    发明人： James B. McClain ,  Charles Douglas Taylor ,  Brett G. Zani ,  John Neet ,  Timothy Charles Kiorpes

    IPC分类号： A61M25/10

    CPC分类号： A61M25/10 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61M25/1011

    摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.

    摘要翻译： 提供一种涂覆的可植入医疗装置，包括：基底; 以及涂层，其设置在所述基底上，其中所述涂层包含至少一种聚合物和至少一种治疗期望形态的药剂和/或至少一种活性生物剂和任选的一种或多种药物载体; 其中基本上所有的药剂和/或活性生物制剂都保留在涂层内和衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将医疗装置部署在受试者的身体中时 一部分药剂和/或活性生物剂在干预部位与至少一部分聚合物和/或药物载体的至少一部分一起递送。

    STENTS AND OTHER DEVICES HAVING EXTRACELLULAR MATRIX COATING
    28.
    发明申请
    STENTS AND OTHER DEVICES HAVING EXTRACELLULAR MATRIX COATING 审中-公开
    STENTS和其他具有细胞基质涂层的设备

    公开(公告)号：US20110264190A1

    公开(公告)日：2011-10-27

    申请号：US13090525

    申请日：2011-04-20

    申请人： James B. McClain ,  Arthur J. Benvenuto

    发明人： James B. McClain ,  Arthur J. Benvenuto

    IPC分类号： A61F2/84 ,  B05D7/00 ,  A61F2/82

    CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/30 ,  A61L2300/62 ,  A61L2420/02 ,  A61L2420/08 ,  C09D167/04

    摘要： Provided herein are devices comprising a stent; and a coating on said stent comprising a polymer and an active agent, wherein the active agent comprises at least one of: extracellular matrix and an extracellular matrix component. Provided herein are methods of preparing a device comprising a stent and a coating on said stent; said method comprising: providing a stent; and forming a plurality of layers on said stent; wherein the coating comprises a polymer and at least one of said layers comprises one or more active agents; wherein at least a portion of the active agent comprises at least one of extracellular matrix and an extracellular matrix component.

    摘要翻译： 本文提供了包括支架的装置; 以及所述支架上的包含聚合物和活性剂的涂层，其中所述活性剂包括细胞外基质和细胞外基质组分中的至少一种。 本文提供了制备包括支架和在所述支架上的涂层的装置的方法; 所述方法包括：提供支架; 并在所述支架上形成多个层; 其中所述涂层包含聚合物，并且所述层中的至少一个包含一种或多种活性剂; 其中所述活性剂的至少一部分包含细胞外基质和细胞外基质组分中的至少一种。

    STENT AND STENT DELIVERY SYSTEM WITH IMPROVED DELIVERABILITY
    29.
    发明申请
    STENT AND STENT DELIVERY SYSTEM WITH IMPROVED DELIVERABILITY 审中-公开
    具有改进的可交付性的STENT和STENT交付系统

    公开(公告)号：US20110190864A1

    公开(公告)日：2011-08-04

    申请号：US13014632

    申请日：2011-01-26

    申请人： James B. McClain ,  Douglas Taylor ,  David Enscore

    发明人： James B. McClain ,  Douglas Taylor ,  David Enscore

    IPC分类号： A61F2/84 ,  A61F2/82

    CPC分类号： A61F2/958 ,  A61F2/0077 ,  A61F2002/826 ,  A61F2250/003

    摘要： Stent delivery systems having improved deliverability comprising an elongate member having an inflation lumen and a guidewire lumen therein; a balloon having an interior that is in fluid communication with the inflation lumen; and a stent comprising a coating mounted on the balloon. Methods for making stent delivery systems having improved deliverability. Methods for delivering two stent delivery systems concurrently through a guiding catheter, each stent delivery system comprising elongate member having an inflation lumen and a guidewire lumen therein, a balloon having an interior that is in fluid communication with the inflation lumen, and a stent comprising a coating mounted on the balloon. Stent coatings may comprise a pharmaceutical agent at least a portion of which is in crystalline form.

    摘要翻译： 具有改善的输送能力的支架输送系统包括具有充气腔和其中的导丝腔的细长构件; 具有与膨胀腔流体连通的内部的气囊; 以及支架，其包括安装在气囊上的涂层。 用于制备具有改善的输送性的支架输送系统的方法。 用于通过引导导管同时递送两个支架输送系统的方法，每个支架输送系统包括具有充气腔和其中的导丝腔的细长构件，具有与充气腔流体连通的内部的球囊，以及支架， 涂层安装在气球上。 支架涂层可以包含至少一部分为结晶形式的药剂。