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21.Fibrinogen receptor antagonists for inhibiting aggregation of blood platelets 失效
标题翻译: 用于抑制血小板聚集的纤维蛋白原受体拮抗剂公开(公告)号:US5455243A
公开(公告)日:1995-10-03
申请号:US169947
申请日:1993-12-20
申请人: Mark E. Duggan , Melissa S. Egbertson , Nathan Ihle , George D. Hartman , Laura M. Turchi , William F. Hoffman
发明人: Mark E. Duggan , Melissa S. Egbertson , Nathan Ihle , George D. Hartman , Laura M. Turchi , William F. Hoffman
IPC分类号: A61K31/40 , A61K31/435 , A61K31/54 , A61P7/02 , C07C237/12 , C07C237/20 , C07D207/24 , C07D211/72 , C07D211/76 , C07D239/36 , C07D241/04 , C07D279/12 , C07D283/00 , C07D401/06 , C07D401/12 , C07D401/14 , C07D417/06 , C07D453/02 , C07D453/06 , A61K31/395
CPC分类号: C07D401/06 , C07D211/76 , C07D401/14 , C07D417/06 , C07D453/06
摘要: Fibrinogen receptor antagonists of the formula: ##STR1## such as ##STR2## are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets.
摘要翻译: 以下公式的纤维蛋白原受体拮抗剂:IMA图像公开了用于抑制纤维蛋白原与血小板的结合和抑制血小板聚集的作用。
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22.Fibrinogen receptor antagonists for inhibiting aggregation of blood platelets 失效
标题翻译: 用于抑制血小板聚集的纤维蛋白原受体拮抗剂公开(公告)号:US5281585A
公开(公告)日:1994-01-25
申请号:US972668
申请日:1992-11-06
申请人: Mark E. Duggan , Melissa S. Egbertson , Nathan Ihle , George D. Hartman , Laura M. Turchi , William F. Hoffman
发明人: Mark E. Duggan , Melissa S. Egbertson , Nathan Ihle , George D. Hartman , Laura M. Turchi , William F. Hoffman
IPC分类号: A61K31/40 , A61K31/435 , A61K31/54 , A61P7/02 , C07C237/12 , C07C237/20 , C07D207/24 , C07D211/72 , C07D211/76 , C07D239/36 , C07D241/04 , C07D279/12 , C07D283/00 , C07D401/06 , C07D401/12 , C07D401/14 , C07D417/06 , C07D453/02 , C07D453/06 , A61K31/16 , A61K31/395 , A61K31/445
CPC分类号: C07D401/06 , C07D211/76 , C07D401/14 , C07D417/06 , C07D453/06
摘要: Fibrinogen receptor antagonists of the formula: ##STR1## are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets.
摘要翻译: 以下公式的纤维蛋白原受体拮抗剂:IMA图像公开了用于抑制纤维蛋白原与血小板的结合和抑制血小板聚集的作用。
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公开(公告)号:US5981584A
公开(公告)日:1999-11-09
申请号:US23650
申请日:1998-02-03
IPC分类号: C07C311/19 , C07D209/42 , C07D333/38 , C07D487/04 , A61K31/24 , C07C307/02 , C07C309/06 , C07C317/06
CPC分类号: C07D487/04 , C07C311/19 , C07D209/42 , C07D333/38
摘要: Fibrinogen receptor antagonist prodrugs having the structure, for example, of ##STR1## more particularly, ##STR2##
摘要翻译: 具有结构的纤维蛋白原受体拮抗剂前药,例如更具体地,
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公开(公告)号:US5852045A
公开(公告)日:1998-12-22
申请号:US729968
申请日:1996-10-15
申请人: Ben C. Askew , George D. Hartman , Mark E. Duggan , Steven D. Young , John H. Hutchinson , John S. Wai , Melissa S. Egbertson , Laura M. Vassallo , Laura A. Libby , Amy E. Krause , Wasyl Halczenko , Nathan C. Ihle
发明人: Ben C. Askew , George D. Hartman , Mark E. Duggan , Steven D. Young , John H. Hutchinson , John S. Wai , Melissa S. Egbertson , Laura M. Vassallo , Laura A. Libby , Amy E. Krause , Wasyl Halczenko , Nathan C. Ihle
IPC分类号: C07D401/06 , C07D401/14 , C07D405/14 , C07D453/04 , C07D521/00 , C07K5/06 , A61K31/445 , A61K31/495
CPC分类号: C07D231/12 , C07D233/56 , C07D249/08 , C07D401/06 , C07D401/14 , C07D405/14 , C07D453/04 , C07K5/06026
摘要: Fibrinogen receptor antagonists having the structure, for example, of ##STR1## for example ##STR2##
摘要翻译: 具有例如
结构的纤维蛋白原受体拮抗剂,例如 -
公开(公告)号:US5814643A
公开(公告)日:1998-09-29
申请号:US861545
申请日:1997-05-22
申请人: Mark E. Duggan , Melissa S. Egbertson , Wasyl Halczenko , George D. Hartman , William L. Laswell
发明人: Mark E. Duggan , Melissa S. Egbertson , Wasyl Halczenko , George D. Hartman , William L. Laswell
IPC分类号: C07D211/30 , A61K31/185 , A61K31/195 , A61K31/215 , A61K31/255 , A61K31/265 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/435 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/452 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/55 , A61K31/66 , A61P7/02 , A61P43/00 , C07C311/02 , C07C311/06 , C07C311/13 , C07C311/19 , C07C313/06 , C07C313/20 , C07C323/59 , C07C327/12 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/26 , C07D207/273 , C07D209/12 , C07D209/30 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/46 , C07D213/75 , C07D223/08 , C07D233/02 , C07D233/64 , C07D237/08 , C07D239/04 , C07D239/26 , C07D241/04 , C07D241/12 , C07D249/04 , C07D249/08 , C07D263/46 , C07D267/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D453/02 , C07D453/06 , C07D471/08 , C07D487/08 , C07F9/38 , C07F9/40
CPC分类号: C07C311/06 , C07C311/13 , C07D211/22 , C07D409/12
摘要: A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.
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公开(公告)号:US5658929A
公开(公告)日:1997-08-19
申请号:US505417
申请日:1995-07-21
申请人: Mark E. Duggan , Melissa S. Egbertson , Wasyl Halczenko , George D. Hartman , William L. Laswell
发明人: Mark E. Duggan , Melissa S. Egbertson , Wasyl Halczenko , George D. Hartman , William L. Laswell
IPC分类号: C07D211/30 , A61K31/185 , A61K31/195 , A61K31/215 , A61K31/255 , A61K31/265 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/435 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/452 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/55 , A61K31/66 , A61P7/02 , A61P43/00 , C07C311/02 , C07C311/06 , C07C311/13 , C07C311/19 , C07C313/06 , C07C313/20 , C07C323/59 , C07C327/12 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/26 , C07D207/273 , C07D209/12 , C07D209/30 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/46 , C07D213/75 , C07D223/08 , C07D233/02 , C07D233/64 , C07D237/08 , C07D239/04 , C07D239/26 , C07D241/04 , C07D241/12 , C07D249/04 , C07D249/08 , C07D263/46 , C07D267/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D453/02 , C07D453/06 , C07D471/08 , C07D487/08 , C07F9/38 , C07F9/40
CPC分类号: C07C311/06 , C07C311/13 , C07D211/22 , C07D409/12
摘要: A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.
摘要翻译: 作为纤维蛋白原IIb / IIIa受体的拮抗剂的一系列非肽衍生物,因此是可用于预防和治疗由血栓形成引起的疾病的血小板抗聚集化合物。
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公开(公告)号:US5648368A
公开(公告)日:1997-07-15
申请号:US448347
申请日:1995-06-01
申请人: Melissa S. Egbertson , Laura M. Vassallo , George D. Hartman , Wasyl Halczenko , David B. Whitman , James J. Perkins , Amy E. Krause , Nathan Ihle , David Alan Claremon , William Hoffman , Mark E. Duggan
发明人: Melissa S. Egbertson , Laura M. Vassallo , George D. Hartman , Wasyl Halczenko , David B. Whitman , James J. Perkins , Amy E. Krause , Nathan Ihle , David Alan Claremon , William Hoffman , Mark E. Duggan
IPC分类号: C07D295/08 , A61K31/395 , A61K31/397 , A61K31/40 , A61K31/415 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/495 , A61P7/02 , A61P43/00 , C07C255/57 , C07C271/22 , C07C309/66 , C07C311/19 , C07D205/04 , C07D207/08 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/34 , C07D211/46 , C07D211/70 , C07D213/30 , C07D213/71 , C07D233/54 , C07D233/60 , C07D233/64 , C07D295/084 , C07D295/092 , C07D295/096 , C07D295/155 , C07D401/12 , C07D409/12 , C07D521/00 , C07D211/20 , C07D211/98
CPC分类号: C07D213/30 , C07C311/19 , C07D205/04 , C07D211/22 , C07D211/26 , C07D211/34 , C07D211/46 , C07D211/70 , C07D213/71 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/084 , C07D295/088 , C07D295/096 , C07D295/155 , C07D401/12 , C07D409/12
摘要: Novel fibrinogen receptor antagonists of the formula:X--Y--Z--Aryl--A--Bare provided in which the claimed compounds exhibit fibrinogen receptor antagonist activity, inhibit platelet aggregation and are therefore useful in modulating thrombus formation.
摘要翻译: PCT No.PCT / US93 / 11623 Sec。 371日期:1995年6月1日 102(e)1995年6月1日PCT 1993年11月29日PCT PCT。 公开号WO94 / 12181 日期1994年6月9日提供了以下结构式的新型纤维蛋白原受体拮抗剂:X-Y-Z-芳基-A-Bare,其中要求保护的化合物表现出纤维蛋白原受体拮抗剂活性,抑制血小板聚集,因此可用于调节血栓形成。
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公开(公告)号:US5525617A
公开(公告)日:1996-06-11
申请号:US295316
申请日:1994-08-24
IPC分类号: C07D211/34 , A61K31/445 , A61K31/40 , C07D207/09 , C07D211/06
CPC分类号: C07D211/34
摘要: Fibrinogen receptor antagonists having the formula ##STR1## for example ##STR2##
摘要翻译: 具有式
的纤维蛋白原受体拮抗剂例如 -
公开(公告)号:US5264420A
公开(公告)日:1993-11-23
申请号:US860748
申请日:1992-03-25
申请人: Mark E. Duggan , Melissa S. Egbertson , Nathan Ihle , George D. Hartman , Laura M. Turchi , David Whitman
发明人: Mark E. Duggan , Melissa S. Egbertson , Nathan Ihle , George D. Hartman , Laura M. Turchi , David Whitman
IPC分类号: C07D211/34 , C07D401/12 , A61K37/02 , C07K5/02 , C07K5/06 , C07K5/08
CPC分类号: C07D401/12 , C07D211/34
摘要: Fibrinogen receptor antagonists of the formula: ##STR1## are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets.
摘要翻译: 公开了用于抑制纤维蛋白原与血小板结合和抑制血小板聚集的式I的纤维蛋白原受体拮抗剂。
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