公开(公告)号：US6146630A

公开(公告)日：2000-11-14

申请号：US946838

申请日：1997-10-08

申请人： Kazuo Tsubota ,  Tsutomu Takeuchi

发明人： Kazuo Tsubota ,  Tsutomu Takeuchi

IPC分类号： A61K38/00 ,  A61K39/395 ,  A61P5/00 ,  A61P27/02 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P43/00 ,  C07K16/28

CPC分类号： C07K16/2839 ,  C07K16/28 ,  A61K2039/505

摘要： The present invention provides adhesion inhibitors for suppressing the adherence between E-cadherin of glandular cells and integrin of lymphocytes. Sjogren's syndrome comprises disorders wherein secretory glands such as lacrimal gland are destroyed by autoimmunity, and the adherence of CD8.sup.+ T cells to the surface of acinar cells is observed by the immunohistological analysis of lacrimal gland from patients. Integrin on the surface of T cells and E-cadherin on the surface of acinar cells play a major role in the mechanism of adhesion between these cells, while the adherence of T cells to acinar cells is reduced using anti-E-cadherin and anti-integrin antibodies. Sjogren's syndrome, such as autoimmune adenitis, can be treated using these antibodies.

摘要翻译： 本发明提供了抑制腺细胞的E-钙粘蛋白与淋巴细胞的整联蛋白之间粘附的粘合抑制剂。 Sj + E，cir o + EE gren综合征包括其中分泌腺如泪腺被自身免疫破坏的疾病，并且通过对患者的泪腺的免疫组织学分析观察到CD8 + T细胞对腺泡细胞表面的粘附。 在腺泡细胞表面的T细胞和E-钙粘蛋白表面的整合素在这些细胞之间的粘附机制中起主要作用，而使用抗E-钙粘蛋白和抗E-钙粘蛋白减少T细胞对腺泡细胞的粘附， 整合素抗体。 可以使用这些抗体治疗Sj + E，cir o + EE gren综合征，例如自身免疫性腺炎。