公开(公告)号：US06383646B1

公开(公告)日：2002-05-07

申请号：US09704003

申请日：2000-11-01

申请人： Yutaka Tomioka ,  Satoshi Horiuchi ,  Shingo Kasahara ,  Katsuhiro Kawakami ,  Toru Ueno ,  Hiroyuki Takada ,  Yukinari Matsumoto ,  Narumitsu Suda ,  Shigeyuki Yamada

发明人： Yutaka Tomioka ,  Satoshi Horiuchi ,  Shingo Kasahara ,  Katsuhiro Kawakami ,  Toru Ueno ,  Hiroyuki Takada ,  Yukinari Matsumoto ,  Narumitsu Suda ,  Shigeyuki Yamada

IPC分类号： B32B1706

CPC分类号： C04B41/009 ,  C04B41/52 ,  C04B41/89 ,  C04B41/4543 ,  C04B41/4572 ,  C04B41/4578 ,  C04B41/504 ,  C04B41/5022 ,  C04B2103/54 ,  C04B41/0072 ,  C04B33/00

摘要： Sanitary ware which strongly resists adhesion of dirt and which may be easily cleaned with a weak flow of water, over a long period of time, comprises a first coloring glaze layer formed on the surface of a ceramic body, a second transparent glaze layer formed on the first glaze layer, and an engobe layer formed between said body surface and said first glaze layer.

摘要翻译： 能够长时间地强力抵抗污物粘附并易于被弱水流清洗的卫生洁具包括在陶瓷体表面上形成的第一着色釉层，形成在陶瓷体表面上的第二透明釉层 第一釉层和形成在所述体表面和所述第一釉层之间的釉面层。

公开(公告)号：US06194434B1

公开(公告)日：2001-02-27

申请号：US09171637

申请日：1998-10-22

申请人： Makoto Takemura ,  Youichi Kimura ,  Katsuhiro Kawakami ,  Hitoshi Ohki

发明人： Makoto Takemura ,  Youichi Kimura ,  Katsuhiro Kawakami ,  Hitoshi Ohki

IPC分类号： A61K3147

CPC分类号： C07D401/04

摘要： A quinolone derivative represented by formula (I): wherein R1 represents a cycloalkyl group; R2 represents a hydrogen atom, an amino group, a hydroxyl group, a thiol group, a halogenomethyl group, an alkyl group, an alkenyl group, an alkynyl group, or an alkoxyl group; R3 represents an amino group, a halogenomethyl group, a halogenomethoxyl group, an alkyl group, an alkenyl group, an alkynyl group, or an alkoxyl group; R4 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; R5 represents a cycloalkyl group having 3 to 6 carbon atoms; the above R1 to R5 may be substituted; X represents a halogen atom or a hydrogen atom; and Y represents a hydrogen atom, a phenyl group, an acetoxymethyl group, a pivaloyloxymethyl group, an ethoxycarbonyl group, a choline group, a dimethylaminoethyl group, a 5-indanyl group, a phthalidinyl group, a 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl group, a 3-acetoxy-2-oxobutyl group, an alkyl group having 1 to 6 carbon atoms, an alkoxymethyl group having 2 to 7 carbon atoms, or a phenylalkyl group having 1 to 6 carbon atoms in the alkyl moiety thereof, or a salt thereof. The compound exhibits high and broad antimicrobial activity against various bacteria including bacteria resistant to drugs and high safety.

摘要翻译： 由式（I）表示的喹诺酮衍生物：其中R1表示环烷基; R2表示氢原子，氨基，羟基，硫醇基，卤代甲基，烷基，烯基，炔基或烷氧基; R3表示氨基，卤代甲基，卤代甲氧基，烷基，烯基，炔基或烷氧基; R4表示氢原子或碳原子数1〜6的烷基。 R5表示碳原子数3〜6的环烷基; 上述R 1〜R 5可以被取代; X表示卤素原子或氢原子; Y表示氢原子，苯基，乙酰氧基甲基，新戊酰氧基甲基，乙氧基羰基，胆碱基，二甲基氨基乙基，5-二氢化茚基，苯酞基，5-烷基-2-氧代 - 1,3-二氧杂环戊烯-4-基甲基，3-乙酰氧基-2-氧代丁基，碳原子数1〜6的烷基，碳原子数2〜7的烷氧基甲基或碳原子数1〜6的苯基烷基 其烷基部分的原子，或其盐。 该化合物对各种细菌（包括对药物有抗性的细菌和高安全性）具有高而广的抗菌活性。

公开(公告)号：US5693814A

公开(公告)日：1997-12-02

申请号：US303812

申请日：1994-09-12

申请人： Youichi Kimura ,  Katsuhiro Kawakami ,  Norimasa Mikata ,  Keiji Uchiyama ,  Tazuo Uemura ,  Yusuke Yukimoto

发明人： Youichi Kimura ,  Katsuhiro Kawakami ,  Norimasa Mikata ,  Keiji Uchiyama ,  Tazuo Uemura ,  Yusuke Yukimoto

IPC分类号： A61K9/00 ,  C07D401/04 ,  A61K31/47 ,  A61K31/4747 ,  A61P31/04 ,  A61P35/04 ,  C07B63/00 ,  C07D215/56 ,  C07D221/00 ,  C07D401/10 ,  C07D403/04 ,  C07D471/04 ,  C07D215/18 ,  C07D215/38

CPC分类号： C07D401/04

摘要： A method for selectively obtaining any one of an anhydrate, a 1/2 hydrate, a 1 hydrate, and a 3/2 hydrate of 7-�(7-(S)-amino-5-azaspiro�2.4!heptan-5-yl!-8-chloro-6-fluoro-1-�(1R,2S)-2-fluorocyclopropyl!-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is disclosed, comprising treating the compound in an aqueous solvent or water or recrystallizing the compound from an aqueous solvent or water.

摘要翻译： 一种选择性地获得7 - [（7-（S） - （C 1 -C 6）烯的水合物，+ E，F 1/2 + EE水合物，1水合物和+ 氨基-5-氮杂螺[2.4]庚-5-基] -8-氯-6-氟-1 - [（1R，2S）-2-氟环丙基] -4-氧代-1,4-二氢喹啉-3-羧酸 酸，包括在水性溶剂或水中处理化合物或者从水性溶剂或水中重结晶化合物。