Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same
    22.
    发明申请
    Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same 有权
    苯并噻吩-2-羰基胍衍生物及其制备方法和含有它们的药物组合物

    公开(公告)号:US20100004466A1

    公开(公告)日:2010-01-07

    申请号:US11794238

    申请日:2005-12-27

    IPC分类号: C07D333/54

    CPC分类号: C07D333/70

    摘要: The present invention is related to benzothiophen-2-carbonylguanidine derivatives, a preparation method thereof, and pharmaceutical compositions containing the same. The derivatives have potent inhibitory effect on the sodium/hydrogen exchanger NHE-I, improve the functional recovery of ischemia/reperfusion-induced heart injury in isolated ischemic heart models, and significantly reduce the myocardiac infarct size in in vivo ischemic animal models, thereby showing excellent cardioprotective effects. Also, the derivatives are protective of both neuronal cells and the brain as proven by their protective effects on neuronal cells from necrosis and apoptosis and by their ability to significantly reduce cerebral infarct sizes in in vivo ischemic brain models. The derivatives can be effectively used for the prevention and treatment of ischemic heart diseases such as myocardiac infarction, arrhythmia, angina pectoris and the like, and cerebrovascular diseases such as cerebral stroke and be used as cardioprotective agents to the patients undergoing reperfusion therapy including chemicals such as thrombolytic agents, or surgery such as coronary artery bypass and percutaneous transluminal coronary angioplasty.

    摘要翻译: 本发明涉及苯并噻吩-2-羰基胍衍生物,其制备方法和含有它们的药物组合物。 该衍生物对钠/氢交换器NHE-1具有有效的抑制作用,改善了分离缺血心脏模型缺血/再灌注诱导的心脏损伤的功能恢复,并显着降低了体内缺血动物模型中的心肌梗死面积,从而显示 良好的心脏保护作用。 此外,衍生物保护神经元细胞和脑,如通过其对来自坏死和凋亡的神经元细胞的保护作用以及通过其在体内缺血性脑模型中显着降低脑梗塞大小的能力所证明的。 该衍生物可以有效地用于预防和治疗心肌梗塞,心律失常,心绞痛等缺血性心脏病,脑血管疾病如脑卒中,并用作心脏保护剂,用于接受再灌注治疗的患者,包括化学药剂 作为溶栓剂,或手术如冠状动脉旁路和经皮腔内冠状动脉成形术。

    System and method for verifying integrity of software package in mobile terminal

    公开(公告)号:US09832651B2

    公开(公告)日:2017-11-28

    申请号:US12761874

    申请日:2010-04-16

    IPC分类号: H04W12/10 G06F21/57 H04L29/06

    CPC分类号: H04W12/10 G06F21/57 H04L63/12

    摘要: A method and system for verifying integrity of a software package in a mobile terminal is provided. The method includes receiving a catalog of available software packages from a distributor and displaying the catalog, if a desired software package to be installed is selected from the displayed catalog, acquiring a software package IDentifier (ID) corresponding to the selected software package from the catalog, transmitting the software package ID to the distributor to receive the selected software package corresponding to the software package ID and to transmit the software package ID to a verification authority, receiving, from the verification authority, integrity evidence information corresponding to the software package ID and verifying the integrity of the selected software package, and outputting a notification for notifying a user of a result of the verification and managing the selected software package according to a received user selection.

    Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same
    25.
    发明授权
    Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same 有权
    苯并噻吩-2-羰基胍衍生物及其制备方法和含有它们的药物组合物

    公开(公告)号:US08143307B2

    公开(公告)日:2012-03-27

    申请号:US11794238

    申请日:2005-12-27

    IPC分类号: A61K31/381 C07D333/56

    CPC分类号: C07D333/70

    摘要: The present invention is related to benzothiophen-2-carbonylguanidine derivatives, a preparation method thereof, and pharmaceutical compositions containing the same. The derivatives have potent inhibitory effect on the sodium/hydrogen exchanger NHE-I, improve the functional recovery of ischemia/reperfusion-induced heart injury in isolated ischemic heart models, and significantly reduce the myocardiac infarct size in in vivo ischemic animal models, thereby showing excellent cardioprotective effects. Also, the derivatives are protective of both neuronal cells and the brain as proven by their protective effects on neuronal cells from necrosis and apoptosis and by their ability to significantly reduce cerebral infarct sizes in in vivo ischemic brain models. The derivatives can be effectively used for the prevention and treatment of ischemic heart diseases such as myocardiac infarction, arrhythmia, angina pectoris and the like, and cerebrovascular diseases such as cerebral stroke and be used as cardioprotective agents to the patients undergoing reperfusion therapy including chemicals such as thrombolytic agents, or surgery such as coronary artery bypass and percutaneous transluminal coronary angioplasty.

    摘要翻译: 本发明涉及苯并噻吩-2-羰基胍衍生物,其制备方法和含有它们的药物组合物。 该衍生物对钠/氢交换器NHE-1具有有效的抑制作用,改善了分离缺血心脏模型缺血/再灌注诱导的心脏损伤的功能恢复,并显着降低了体内缺血动物模型中的心肌梗死面积,从而显示 良好的心脏保护作用。 此外,衍生物保护神经元细胞和脑,如通过其对来自坏死和凋亡的神经元细胞的保护作用以及通过其在体内缺血性脑模型中显着降低脑梗塞大小的能力所证明的。 该衍生物可以有效地用于预防和治疗心肌梗塞,心律失常,心绞痛等缺血性心脏病,脑血管疾病如脑卒中,并用作心脏保护剂,用于接受再灌注治疗的患者,包括化学药剂 作为溶栓剂,或手术如冠状动脉旁路和经皮腔内冠状动脉成形术。

    Apparatus and method for providing users with road traffic information using ad-hoc network
    26.
    发明授权
    Apparatus and method for providing users with road traffic information using ad-hoc network 有权
    使用ad-hoc网络为用户提供道路交通信息的装置和方法

    公开(公告)号:US07430218B2

    公开(公告)日:2008-09-30

    申请号:US10808752

    申请日:2004-03-25

    IPC分类号: H04J15/00

    摘要: A traffic information service apparatus using an ad-hoc network and a method for controlling the same. The apparatus provides an ad-hoc network between vehicles and roadside devices, and collects/provides traffic information using the ad-hoc network. The method for providing a user with traffic information, comprising the steps of a) allowing vehicles to broadcast their registration messages to create an ad-hoc network, and creating the ad-hoc network between the vehicles on the basis of the registration messages, b) allowing a Road Side Equipment (RSE) to receive the registration messages broadcast from the vehicles, and collecting traffic information from the registration messages, and c) allowing the RSE to transmit the traffic information to a traffic information service center.

    摘要翻译: 一种使用自组织网络的交通信息服务装置及其控制方法。 该装置提供车辆和路边设备之间的自组织网络,并且使用自组织网络收集/提供交通信息。 用于向用户提供交通信息的方法,包括以下步骤:a)允许车辆广播其注册消息以创建自组织网络,以及基于所述注册消息在所述车辆之间创建所述ad-hoc网络,b ),允许路侧设备(RSE)接​​收从车辆广播的注册消息,并从注册消息中收集交通信息,以及c)允许RSE将交通信息传输到交通信息服务中心。