公开(公告)号：US06482620B1

公开(公告)日：2002-11-19

申请号：US09496005

申请日：2000-02-01

申请人： Maria Alexandra Glucksmann

发明人： Maria Alexandra Glucksmann

IPC分类号： C12N902

CPC分类号： C40B30/04 ,  C12N9/0071 ,  C12Q1/26 ,  G01N33/6845 ,  G01N33/92 ,  G01N2500/02 ,  G01N2500/10 ,  G01N2500/20

摘要： The present invention relates to a newly identified human gamma-butyrobetaine hydroxylase (&ggr;-BBH). The invention also related to polynucleotides encoding the gamma-butyrobetaine hydroxylases. The invention further relates to methods using the &ggr;-BBH polypeptides and polynucleotides as a target for diagnosis and treatment in &ggr;-BBH-mediated or -related disorders. The invention further relates to drug-screening methods using the &ggr;-BBH polypetides and poly-nucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the &ggr;-BBH polypeptides and polynucleotides. The invention further relates to procedures for producing the polypeptides and polynucleotides.

摘要翻译： 本发明涉及新鉴定的人γ-丁酰谷氨酸羟化酶（γ-BBH）。 本发明还涉及编码γ-丁酸甜菜碱羟化酶的多核苷酸。 本发明还涉及使用γ-BBH多肽和多核苷酸作为在γ-BBH介导的或相关疾病中进行诊断和治疗的靶标的方法。 本发明进一步涉及使用γ-BBH多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于γ-BBH多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及产生多肽和多核苷酸的方法。