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公开(公告)号:US07084108B2
公开(公告)日:2006-08-01
申请号:US10001945
申请日:2001-11-01
申请人: Gary L. Olson , Christopher Self , Lily Lee , Charles Michael Cook , Jens Birktoft , Barry Morgan , Christopher C. Arico-Muendel
发明人: Gary L. Olson , Christopher Self , Lily Lee , Charles Michael Cook , Jens Birktoft , Barry Morgan , Christopher C. Arico-Muendel
IPC分类号: A61K31/336 , A61K38/08 , C07D303/32 , C07K7/06
CPC分类号: A61K38/4886 , A61K47/64 , C07D405/14 , C07K5/0202 , C07K5/0606 , C07K5/0806 , C07K5/081 , C07K5/0817 , C07K5/1008 , C07K14/8146
摘要: The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an angiogenic disease, e.g., cancer, in a subject by administering to the subject a therapeutically effective amount of one or more of the angiogenesis inhibitor compounds of the invention.
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22.
公开(公告)号:US07105482B2
公开(公告)日:2006-09-12
申请号:US10429174
申请日:2003-05-02
申请人: Gary L. Olson , Christopher Self , Lily Lee , Charles Michael Cook , Jens Birktoft , Barry Morgan , Christopher C. Arico-Muendel
发明人: Gary L. Olson , Christopher Self , Lily Lee , Charles Michael Cook , Jens Birktoft , Barry Morgan , Christopher C. Arico-Muendel
IPC分类号: A61K31/336 , A61K38/08
CPC分类号: A61K38/4886 , A61K38/05 , A61K38/07 , A61K38/08 , A61K47/64 , C07D303/16 , C07D405/14 , C07K5/0202 , C07K5/0606 , C07K5/06078 , C07K5/0806 , C07K5/081 , C07K5/0817 , C07K5/1008 , C07K5/1024 , C07K7/06 , C07K14/8146 , Y02A50/409 , Y02A50/411
摘要: The present invention provides methods of treating, parasitic infections, thymoma, and lymphoid malignancies in a subject by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention.
摘要翻译: 本发明通过向受试者施用治疗有效量的一种或多种本发明化合物来提供治疗受试者的寄生虫感染,胸腺瘤和淋巴恶性肿瘤的方法。
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