公开(公告)号：US20160031931A1

公开(公告)日：2016-02-04

申请号：US14776870

申请日：2014-02-24

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Mark David Simon ,  Bradley L. Pentelute ,  Andrea Adamo ,  Patrick Louis Heider ,  Klavs F. Jensen

IPC: C07K1/04 ,  C07K1/08 ,  C07K1/06

CPC classification number: C07K1/042 ,  C07K1/045 ,  C07K1/061 ,  C07K1/08

Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.

Abstract translation: 通常描述用于进行固相肽合成的系统和方法。 固相肽合成是将已经固定在固体支持物上的肽加入氨基酸残基的已知方法。 在某些实施方案中，本发明的系统和方法可用于快速进行固相肽合成，同时保持高产率。 某些实施方案涉及可用于以减少进行固相肽合成所需时间量的方式加热，运输和/或混合试剂的方法和系统。