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公开(公告)号:US20070225297A1
公开(公告)日:2007-09-27
申请号:US11717991
申请日:2007-03-14
申请人: Robert Perni , Youssef Bennani , Gregor Zlokarnik , Gerald Tanoury , Minzhang Chen , Young Jung , Raymond Forslund , Francois Maltais
发明人: Robert Perni , Youssef Bennani , Gregor Zlokarnik , Gerald Tanoury , Minzhang Chen , Young Jung , Raymond Forslund , Francois Maltais
IPC分类号: A61K31/497 , C07D403/02 , C07D413/02 , C07D417/02
CPC分类号: C07C231/20 , C07B2200/05 , C07B2200/07 , C07C237/04 , C07C2601/02 , C07D209/52 , C07D301/14 , C07D303/48 , C07D401/14 , C07D403/12 , C07D403/14 , C07D498/10 , C07K5/0202 , C07K7/02
摘要: A deuterated α-ketoamido steric specific compound of the formula wherein D denotes a deuterium atom on a steric specific carbon atom.
摘要翻译: 具有下式的氘代α-酮糖胺基空间特异性化合物其中D表示空间特异性碳原子上的氘原子。
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22.Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof 有权
标题翻译: 制备(1R,2S,5S)-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸盐或其盐的方法和中间体公开(公告)号:US20050059648A1
公开(公告)日:2005-03-17
申请号:US10867602
申请日:2004-06-15
申请人: Jeonghan Park , Anantha Sudhakar , George Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-Jong Kwok , Ingyu Jeon , Ramani Raghavan , Maria Tamarez , Weidong Tong , Eugene Vater
发明人: Jeonghan Park , Anantha Sudhakar , George Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-Jong Kwok , Ingyu Jeon , Ramani Raghavan , Maria Tamarez , Weidong Tong , Eugene Vater
IPC分类号: C07C69/74 , C07C215/20 , C07C233/58 , C07C271/18 , C07D209/52 , A61K31/33
CPC分类号: C07C233/58 , C07B2200/07 , C07C69/74 , C07C215/20 , C07C271/18 , C07C2601/02 , C07D209/52
摘要: In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译: 在一个实施方案中,本申请涉及制备式I化合物和在制备式I化合物的方法中制备的某些中间体化合物的方法。
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公开(公告)号:US08383858B2
公开(公告)日:2013-02-26
申请号:US12806014
申请日:2010-08-04
IPC分类号: C07J9/00 , C07C233/06
CPC分类号: C07C231/12 , C07B2200/05 , C07B2200/07 , C07C51/412 , C07C59/255 , C07C231/20 , C07C237/04 , C07C247/04 , C07C247/06 , C07C2601/02 , C07D209/52 , C07D301/14 , C07D303/48 , C07D401/14 , C07D403/12 , C07D403/14 , C07D498/10 , C07J9/005 , C07J75/00 , C07K5/0202 , C07K7/02
摘要: This invention relates to processes and intermediates for the preparation of an alpha-amino beta-hydroxy acid of Formula 1 wherein the variables R1, R′1 and R2 are defined herein and the compound of Formula 1 has an enantiomeric excess (ee) of 55% or greater.
摘要翻译: 本发明涉及用于制备式1的α-氨基β-羟基酸的方法和中间体,其中变量R1,R'1和R2在本文中定义,式1的化合物具有55的对映体过量(ee) %以上。
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公开(公告)号:US07381827B2
公开(公告)日:2008-06-03
申请号:US11078147
申请日:2005-03-11
申请人: Gerald J. Tanoury , Minzhang Chen , Andrew D. Jones , Philip L. Nyce , Martin Trudeau , David J. Guerin , John R. Snoonian
发明人: Gerald J. Tanoury , Minzhang Chen , Andrew D. Jones , Philip L. Nyce , Martin Trudeau , David J. Guerin , John R. Snoonian
IPC分类号: C07D207/06 , C07D295/02 , C07D305/00 , C07C239/00
CPC分类号: C07D207/16 , C07D209/52 , C07D211/60 , C07D405/12 , C07D417/06 , C07D417/12 , C07D417/14 , Y02P20/55
摘要: The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
摘要翻译: 本发明涉及可用于生产改性天冬氨酸衍生物如天冬氨酸醛部分的方法和化合物。 天冬氨酸衍生物可用于制备半胱天冬酶抑制剂和/或其前药。
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25.
公开(公告)号:US06992189B2
公开(公告)日:2006-01-31
申请号:US10401070
申请日:2003-03-27
申请人: William Leong , Minzhang Chen , Bosco A. D'sa , Man Zhu , Tong Xiao , Xiongwei Shi , Suhan Tang , Dinesh Gala , Andrew J. Goodman , Christopher M. Nielsen , Gary M. Lee , Juan A. Gamboa , Andrew D. Jones
发明人: William Leong , Minzhang Chen , Bosco A. D'sa , Man Zhu , Tong Xiao , Xiongwei Shi , Suhan Tang , Dinesh Gala , Andrew J. Goodman , Christopher M. Nielsen , Gary M. Lee , Juan A. Gamboa , Andrew D. Jones
IPC分类号: C07D403/14
CPC分类号: C07D401/06 , C07D401/14
摘要: In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV:
摘要翻译: 在其几个实施方案中,本发明公开了制备式II和式IV化合物的新方法:
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公开(公告)号:US06936718B2
公开(公告)日:2005-08-30
申请号:US10305100
申请日:2002-11-26
申请人: Minzhang Chen , Bosco D'sa , William Leong , Suhan Tang
发明人: Minzhang Chen , Bosco D'sa , William Leong , Suhan Tang
IPC分类号: A61K31/444 , A61K31/4545 , A61P11/06 , A61P19/02 , A61P19/06 , A61P29/00 , A61P31/18 , A61P37/08 , A61P43/00 , C07D401/14 , C07D211/54 , C07D211/30
CPC分类号: C07D401/14 , A61K31/444
摘要: In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of specific, preferred rotamer or rotameric pair of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing desired rotamers of pharmaceutically useful salts.
摘要翻译: 在一个实施方案中,本发明公开了一种通过创造性地选择溶剂介质来直接制备特定的,优选的旋转异构体或旋转异构体的一对酸性盐与碱性化合物的比例不等的方法。 该方法特别可用于制备药学上可用的盐的所需旋转异构体。
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27.Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl 失效
标题翻译: 制备(1R,2S,5S)-3-氮杂双环[3,1,0]己烷-2-甲酰胺,N- [3-氨基-1-(环丁基甲基)-2,3-二氧代丙基] -3 - [(2S)-2 - [[[1,1-二甲基乙基]氨基]羰基氨基] -3,3-二甲基-1-氧代丁基] -6,6-二甲基公开(公告)号:US20050059800A1
公开(公告)日:2005-03-17
申请号:US10867600
申请日:2004-06-15
申请人: Anantha Sudhakar , Vilas Dahanukar , Ilia Zavialov , Cecilia Orr , Hoa Nguyen , Juergen Weber , Ingyu Jeon , Minzhang Chen , Michael Green , George Wong , Jeonghan Park , Tetsuo Iwama
发明人: Anantha Sudhakar , Vilas Dahanukar , Ilia Zavialov , Cecilia Orr , Hoa Nguyen , Juergen Weber , Ingyu Jeon , Minzhang Chen , Michael Green , George Wong , Jeonghan Park , Tetsuo Iwama
IPC分类号: C07C271/22 , C07K5/02 , C07K5/06
CPC分类号: C07K5/0202 , C07C271/22 , C07C2601/04
摘要: In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译: 在一个实施方案中,本申请涉及制备式I化合物的方法以及在制备式I化合物的方法中制备的某些中间体化合物。
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公开(公告)号:US20110071074A1
公开(公告)日:2011-03-24
申请号:US12953876
申请日:2010-11-24
申请人: Robert B. Perni , Youssef Bennani , Gregor Zlokarnik , Gerald J. Tanoury , Minzhang Chen , Young Chun Jung , Raymond E. Forslund , Francois Maltais
发明人: Robert B. Perni , Youssef Bennani , Gregor Zlokarnik , Gerald J. Tanoury , Minzhang Chen , Young Chun Jung , Raymond E. Forslund , Francois Maltais
IPC分类号: A61K38/04
CPC分类号: C07C231/20 , C07B2200/05 , C07B2200/07 , C07C237/04 , C07C2601/02 , C07D209/52 , C07D301/14 , C07D303/48 , C07D401/14 , C07D403/12 , C07D403/14 , C07D498/10 , C07K5/0202 , C07K7/02
摘要: A deuterated α-ketoamido steric specific compound of the formula wherein D denotes a deuterium atom on a steric specific carbon atom.
摘要翻译: 氘代α-酮酰胺基空间特异性化合物,其中D表示空间特异性碳原子上的氘原子。
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公开(公告)号:US20100298568A1
公开(公告)日:2010-11-25
申请号:US12806014
申请日:2010-08-04
IPC分类号: C07D403/12 , C07C237/14
CPC分类号: C07C231/12 , C07B2200/05 , C07B2200/07 , C07C51/412 , C07C59/255 , C07C231/20 , C07C237/04 , C07C247/04 , C07C247/06 , C07C2601/02 , C07D209/52 , C07D301/14 , C07D303/48 , C07D401/14 , C07D403/12 , C07D403/14 , C07D498/10 , C07J9/005 , C07J75/00 , C07K5/0202 , C07K7/02
摘要: This invention relates to processes and intermediates for the preparation of an alpha-amino beta-hydroxy acid of Formula 1 wherein the variables R1, R′1 and R2 are defined herein and the compound of Formula 1 has an enantiomeric excess (ee) of 55% or greater.
摘要翻译: 本发明涉及用于制备式1的α-氨基β-羟基酸的方法和中间体,其中变量R1,R'1和R2在本文中定义,式1的化合物具有55的对映体过量(ee) %以上。
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公开(公告)号:US07834200B2
公开(公告)日:2010-11-16
申请号:US12074983
申请日:2008-03-07
申请人: Gerald J. Tanoury , Minzhang Chen , Andrew D. Jones , Philip L. Nyce , Martin Trudeau , David J. Guerin , John R. Snoonian
发明人: Gerald J. Tanoury , Minzhang Chen , Andrew D. Jones , Philip L. Nyce , Martin Trudeau , David J. Guerin , John R. Snoonian
IPC分类号: C07D307/56
CPC分类号: C07D207/16 , C07D209/52 , C07D211/60 , C07D405/12 , C07D417/06 , C07D417/12 , C07D417/14 , Y02P20/55
摘要: The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
摘要翻译: 本发明涉及可用于生产改性天冬氨酸衍生物如天冬氨酸醛部分的方法和化合物。 天冬氨酸衍生物可用于制备半胱天冬酶抑制剂和/或其前药。
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