公开(公告)号：US20210038529A1

公开(公告)日：2021-02-11

申请号：US17071685

申请日：2020-10-15

Applicant: ModernaTX, Inc.

Inventor： Joshua FREDERICK ,  Ailin BAI ,  Vladimir PRESNYAK ,  Stephen G. HOGE ,  Kerry BENENATO ,  Iain MCFADYEN ,  Ellalahewage Sathyajith KUMARASINGHE ,  Susannah HEWITT

IPC: A61K9/51 ,  A61K48/00 ,  A61K38/17 ,  A61K38/20 ,  A61K9/00 ,  A61K39/39 ,  A61K45/06 ,  A61K9/127 ,  C07K14/54 ,  C07K14/545 ,  C07K14/705 ,  A61P35/00 ,  A61K39/395

Abstract: The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36γ (IL-36-gamma) polypeptide), and an immune response co-stimulatory signal polypeptide (e.g., an OX40L polypeptide).

公开(公告)号：US20190114090A1

公开(公告)日：2019-04-18

申请号：US16225989

申请日：2018-12-19

Applicant: ModernaTX, Inc.

Inventor： Joshua P. FREDERICK ,  Ailin BAI

IPC: G06F3/06 ,  G06F11/30

CPC classification number: G06F3/0629 ,  A61K38/177 ,  A61K45/06 ,  A61K48/00 ,  A61P35/00 ,  C07K14/70575 ,  G06F11/3051 ,  G06F11/3093

Abstract: The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules comprising an mRNA encoding an OX40L polypeptide. Also provided is a method for activating T cells or increasing the number of NK cells in a subject in need thereof.