公开(公告)号：US10653712B2

公开(公告)日：2020-05-19

申请号：US16001786

申请日：2018-06-06

Applicant: ModernaTX, Inc.

Inventor： Stephen Hoge ,  William Issa ,  Edward J. Miracco ,  Jennifer Nelson ,  Amy E. Rabideau ,  Gabor Butora

IPC: C12P19/34 ,  A61K31/7105 ,  C07K14/505 ,  A61P33/00 ,  A61P31/12 ,  A61P31/04 ,  A61P35/00 ,  C12N15/10 ,  G01N33/68

Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.