公开(公告)号：US4337270A

公开(公告)日：1982-06-29

申请号：US152217

申请日：1980-05-21

申请人： Kanji Noda ,  Akira Nakagawa ,  Toshiharu Motomura ,  Masayoshi Tsuji ,  Hidetoshi Amano ,  Hiroyuki Ide

发明人： Kanji Noda ,  Akira Nakagawa ,  Toshiharu Motomura ,  Masayoshi Tsuji ,  Hidetoshi Amano ,  Hiroyuki Ide

IPC分类号： A61K31/245 ,  C07C101/72

CPC分类号： C07C235/38 ,  C07C235/56

摘要： Novel anthranilic acid derivatives of the general formula: ##STR1## wherein X is a halogen atom, an alkoxyl group having 1-3 carbon atoms, an alkyl group having 1-3 carbon atoms or a nitro group, n is an integer of 1-2, Y is an alkoxyl group having 1-3 carbon atoms, m is an integer of 2-3, Z is --COCH.dbd.CH-- or --CO--, R.sub.1 is a hydrogen atom or an alkyl group having 1-4 carbon atoms, and pharmaceutically acceptable salts thereof, which derivatives and salts possess a strong antiallergic action and are thus useful as therapeutically active agents for diseases caused by allergies, such as asthma, hay fever, urticaria and atopic dermatitis; an antiallergic composition comprising the same; and a method of alleviating diseases caused by allergies using the same.

摘要翻译： 新型的下式的邻氨基苯甲酸衍生物：其中X为卤素原子，具有1-3个碳原子的烷氧基，具有1-3个碳原子的烷基或硝基，n为1- 2，Y是具有1-3个碳原子的烷氧基，m是2-3的整数，Z是-COCH = CH-或-CO-，R1是氢原子或具有1-4个碳原子的烷基 和其药学上可接受的盐，其衍生物和盐具有强的抗过敏作用，因此可用作由过敏引起的疾病如哮喘，花粉症，荨麻疹和特应性皮炎的治疗活性剂; 包含其的抗过敏组合物; 以及减轻由使用其引起的过敏引起的疾病的方法。