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公开(公告)号:US06197808B1
公开(公告)日:2001-03-06
申请号:US09418890
申请日:1999-10-15
申请人: Shu Jun Cheng , De Chang Wang , Yukihiko Hara , Insu P. Lee , Woong Shick Ahn
发明人: Shu Jun Cheng , De Chang Wang , Yukihiko Hara , Insu P. Lee , Woong Shick Ahn
IPC分类号: A61K3135
CPC分类号: A61K31/353 , A61K31/352
摘要: A method for a treatment of hyperplasia caused by papilloma virus, such as Condyloma acuminata, which comprises concomitantly topically and orally administering at least one tea catechin. Tea catechins do not involve the risk of side-effects and may be easily administered by the patients themselves.
摘要翻译: 一种用于治疗由乳头状瘤病毒引起的增生的方法,例如尖锐湿疣,其包括同时局部和口服施用至少一种茶儿茶素。 茶儿茶素不涉及副作用的风险,并且可以容易地由患者自身施用。
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公开(公告)号:US5804567A
公开(公告)日:1998-09-08
申请号:US919716
申请日:1997-08-27
申请人: Shu Jun Cheng , De Chang Wang , Yong Su Zhen , Hoyoku Nishino , Yukihiko Hara
发明人: Shu Jun Cheng , De Chang Wang , Yong Su Zhen , Hoyoku Nishino , Yukihiko Hara
IPC分类号: A61K45/06 , A01N43/04 , A01N43/16 , A61K31/715 , A61K31/35
CPC分类号: A61K45/06
摘要: A method for treating cancer in a patient by administering to a patient an nti-cancer effective amount of an anti-metabolite selected from the group consisting of 1-.beta.-arabinofuranosylcytosine and 4-amino-4-deoxy-10-methylfolic acid and an anti-oxidant effective amount of a tea polyphenol compound selected from the group consisting of a tea catechin, a theaflavin and a combination of a tea catechin and a theaflavin.
摘要翻译: 一种通过向患者施用抗癌有效量的抗代谢物,其用于治疗患者的癌症的方法,所述抗代谢物选自1-硫脲呋喃糖基胞嘧啶和4-氨基-4-脱氧-10-甲基己酸,和 抗氧化剂有效量的茶多酚化合物,其选自茶儿茶素,茶黄素以及茶儿茶素和茶黄素的组合。
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公开(公告)号:US5318986A
公开(公告)日:1994-06-07
申请号:US963263
申请日:1992-10-19
申请人: Yukihiko Hara , Miwa Honda
发明人: Yukihiko Hara , Miwa Honda
CPC分类号: A61K31/35 , A23F3/16 , A23L33/105 , A61K36/82
摘要: The effective ingredient in the inventive inhibitive agent against activity of a .alpha.-amylase is tea, e.g., black tea, or a tea polyphenol as a constituent of tea including epigallocatechin gallate, epicatechin gallate, epigallocatechin, epicatechin, (+)catechin and the isomer thereof, free theaflavin, theaflavin monogallates A and B and theaflavin digallate.
摘要翻译: 本发明的抗α-淀粉酶活性抑制剂的有效成分是茶,例如红茶,茶多酚,作为茶的成分,包括表没食子儿茶素没食子酸酯,表儿茶素没食子酸酯,表没食子儿茶素,表儿茶素,(+)儿茶素和异构体 ,免费的茶黄素,茶黄素单糖苷A和B以及茶黄素双胆酸。
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公开(公告)号:US5104901A
公开(公告)日:1992-04-14
申请号:US508083
申请日:1990-04-11
申请人: Tadakatsu Shimamura , Yukihiko Hara
发明人: Tadakatsu Shimamura , Yukihiko Hara
IPC分类号: C07D311/62 , A61K31/35 , A61K31/352 , A61K31/353 , A61K36/00 , A61K36/18 , A61K36/82 , A61P31/00
摘要: The effective ingredient in the inventive medicament against infection with mycoplasma is tea, e.g., black tea, or a tea polyphenol as a constituent of tea including epigallocatechin gallate, epicatechin gallate, epigallocatechin, epicatechin, (+) catechin and the isomer thereof, free theaflavin, theaflavin monogallates A and B and theaflavin digallate.
摘要翻译: 本发明药物抗支原体感染的有效成分是茶,例如红茶,茶多酚,作为茶的成分,包括表没食子儿茶素没食子酸酯,表儿茶素没食子酸酯,表没食子儿茶素,表儿茶素,(+)儿茶素及其异构体,游离茶黄素 ,茶黄素单糖苷A和B和茶黄素digallate。
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公开(公告)号:US4840966A
公开(公告)日:1989-06-20
申请号:US160026
申请日:1988-02-25
申请人: Yukihiko Hara , Tateo Suzuki
发明人: Yukihiko Hara , Tateo Suzuki
IPC分类号: C12N9/99 , A61K31/35 , A61K31/352 , A61K31/353 , A61K31/55 , A61P9/12 , A61P43/00 , C07D311/62
摘要: A method of treating hypertension to reduce blood pressure or to maintain blood pressure at a desired level comprising administering to the patient an effective amount to maintain or lower blood pressure of tea polyphenols. The tea polyphenols include (-)-epigallocatechin gallate, free theaflavin, theaflavin monogallate A, theaflavin monogallate B and theaflavin digallate.
摘要翻译: 一种治疗高血压以降低血压或将血压维持在所需水平的方法,包括向患者施用有效量以维持或降低茶多酚的血压。 茶多酚包括( - ) - 表没食子儿茶素没食子酸酯,游离茶黄素,茶黄素单糖苷A,茶黄素单乙酸酯B和茶黄素二柠檬酸酯。
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公开(公告)号:US20120142947A1
公开(公告)日:2012-06-07
申请号:US13372034
申请日:2012-02-13
申请人: Yukihiko Hara , Hiroshi Hojo , Slobodan Jovanovic
发明人: Yukihiko Hara , Hiroshi Hojo , Slobodan Jovanovic
IPC分类号: C07D311/62
CPC分类号: C07D311/62
摘要: Compositions and methods are directed to covalent adducts between reducing agents and optionally substituted 3-hydroxyflavans, wherein the reducing agent is covalently bound to the B-ring of the 3-hydroxyflavan. Such adducts exhibit markedly increased stability towards oxidation as compared to the unmodified 3-hydroxyflavan. Particularly preferred 3-hydroxyflavans include green tea catechins, and especially EGCG, while especially preferred reducing agents include NAC and glutathione.
摘要翻译: 组合物和方法涉及还原剂和任选取代的3-羟基黄酮之间的共价加合物,其中还原剂与3-羟基黄烷的B-环共价结合。 与未改性的3-羟基黄烷相比,这种加合物显示出显着增加的氧化稳定性。 特别优选的3-羟基黄烷包括绿茶儿茶素,特别是EGCG,而特别优选的还原剂包括NAC和谷胱甘肽。
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公开(公告)号:US08128967B2
公开(公告)日:2012-03-06
申请号:US11817999
申请日:2006-03-08
申请人: Yukihiko Hara
发明人: Yukihiko Hara
CPC分类号: A61K31/60 , A61K31/12 , A61K31/202 , A61K31/33 , A61K31/341 , A61K31/353 , A61K31/355 , A61K31/357 , A61K31/375 , A61K31/415 , A61K31/42 , A61K31/69 , A61K36/38 , A61K36/53 , A61K36/82 , A61K36/9066 , A61K36/9068 , A61K45/06 , A61K2300/00
摘要: Contemplated compositions and methods utilize a combination of a polyphenol and a non-polyphenol cyclooxygenase-2 inhibitor. Preferably, the compositions are pharmaceutical and/or nutraceutical compositions and formulated in a dosage form and amount such that the polyphenol and the non-polyphenol cyclooxygenase-2 inhibitor are effective to reduce tumor incidence and/or multiplicity. In preferred aspects, the polyphenol is epigallocatechin gallate, epigallocatechin, epicatechin gallate, epicatechin, and/or a mixture of polyphenols isolated from a plant (e.g., polyphenon E), and the cyclooxygenase-2 inhibitor is rofecoxib, celecoxib, and/or valdecoxib.
摘要翻译: 考虑的组合物和方法利用多酚和非多酚环氧合酶-2抑制剂的组合。 优选地,组合物是药物和/或营养组合物,并且配制成剂型和剂量使得多酚和非多酚环氧合酶-2抑制剂有效降低肿瘤发生率和/或多重性。 在优选的方面,多酚是表没食子儿茶素没食子酸酯,表没食子儿茶素,表儿茶素没食子酸酯,表儿茶素,和/或从植物分离的多酚的混合物(例如,多酚E),环氧合酶-2抑制剂是罗非昔布,塞来昔布和/或伐地考昔 。
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公开(公告)号:US20100069429A1
公开(公告)日:2010-03-18
申请号:US12631504
申请日:2009-12-04
申请人: Yukihiko Hara , Ryota Seto
发明人: Yukihiko Hara , Ryota Seto
IPC分类号: A61K31/437 , A61K31/353
CPC分类号: A61K36/82 , A23L33/105 , A23V2002/00 , A61K8/97 , A61Q11/00 , A23V2250/214 , A23V2250/2132
摘要: The objective of the present invention is to provide a tea polyphenol composition that has reduced bitterness and astringency while containing catechins with high purity. The present invention provides a tea polyphenol composition, (A) comprising 85% by weight to 95% by weight of catechins, (B) wherein the catechins contains epigallocatechin gallate and gallocatechin gallate at a ratio of 65% by weight to 80% by weight and (C) wherein the ratio given by (epigallocatechin gallate+gallocatechin gallate)/(epicatechin+catechin+epigallocatechin+gallocatechin+epicatechin gallate+catechin gallate) is from 2 to 4.
摘要翻译: 本发明的目的是提供一种含有高纯度儿茶素的苦味和涩味降低的茶多酚组合物。 本发明提供一种茶多酚组合物,(A)包含85重量%至95重量%的儿茶素类,(B)其中儿茶素含有表没食子儿茶素没食子酸酯和没食子儿茶素没食子酸酯,比例为65重量%至80重量% 和(C)其中由(表没食子儿茶素没食子酸没食子酸+没食子儿茶素没食子酸酯)/(表儿茶素+儿茶素+表没食子儿茶素+角叉菜胶+表儿茶素没食子酸酯没食子儿+没食子酸儿茶素没食子酸酯)给出的比例为2〜4。
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公开(公告)号:US20090028963A1
公开(公告)日:2009-01-29
申请号:US11817999
申请日:2006-03-08
申请人: Yukihiko Hara
发明人: Yukihiko Hara
IPC分类号: A61K33/22 , A61K31/415 , A61K31/42 , A61K36/00 , A61P35/00 , A61K36/38 , A61K31/352 , A61K31/60
CPC分类号: A61K31/60 , A61K31/12 , A61K31/202 , A61K31/33 , A61K31/341 , A61K31/353 , A61K31/355 , A61K31/357 , A61K31/375 , A61K31/415 , A61K31/42 , A61K31/69 , A61K36/38 , A61K36/53 , A61K36/82 , A61K36/9066 , A61K36/9068 , A61K45/06 , A61K2300/00
摘要: Contemplated compositions and methods utilize a combination of a polyphenol and a non-polyphenol cyclooxygenase-2 inhibitor. Preferably, the compositions are pharmaceutical and/or nutraceutical compositions and formulated in a dosage form and amount such that the polyphenol and the non-polyphenol cyclooxygenase-2 inhibitor are effective to reduce tumor incidence and/or multiplicity. In preferred aspects, the polyphenol is epigallocatechin gallate, epigallocatechin, epicatechin gallate, epicatechin, and/or a mixture of polyphenols isolated from a plant (e.g., polyphenon E), and the cyclooxygenase-2 inhibitor is rofecoxib, celecoxib, and/or valdecoxib.
摘要翻译: 考虑的组合物和方法利用多酚和非多酚环氧合酶-2抑制剂的组合。 优选地,组合物是药物和/或营养组合物,并且配制成剂型和剂量使得多酚和非多酚环氧合酶-2抑制剂有效降低肿瘤发生率和/或多重性。 在优选的方面,多酚是表没食子儿茶素没食子酸酯,表没食子儿茶素,表儿茶素没食子酸酯,表儿茶素,和/或从植物分离的多酚的混合物(例如,多酚E),环氧合酶-2抑制剂是罗非昔布,塞来昔布和/或伐地考昔 。
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公开(公告)号:US20050090564A1
公开(公告)日:2005-04-28
申请号:US10974253
申请日:2004-10-26
申请人: Paul Wegener , Yukihiko Hara
发明人: Paul Wegener , Yukihiko Hara
IPC分类号: A01N25/00 , A61K9/00 , A61K31/353 , A61K36/82
CPC分类号: A61K36/00 , A61K9/0034 , A61K31/353 , A61K36/82
摘要: Bacterial vaginosis is treated using methods and compositions that include one or more plant polyphenols as active ingredients. Preferred routes of administration of contemplated plant polyphenols include topical and oral administration, and particularly preferred plant polyphenols are prepared from green tea (e.g., Polyphenon E) and/or may include (−)-epigallocatechin gallate, (−)-epicatechin gallate, (−)-epigallocatechin, and (−)-epicatechin.
摘要翻译: 使用包含一种或多种植物多酚作为活性成分的方法和组合物治疗细菌性阴道病。 预期的植物多酚的优选给药途径包括局部和口服给药,特别优选的植物多酚由绿茶(例如Polyphenon E)制备和/或可包括( - ) - 表没食子儿茶素没食子酸酯,( - ) - 表儿茶素没食子酸酯( - ) - 表没食子儿茶素和( - ) - 表儿茶素。
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