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88 条记录 (耗时 0.035 秒)

    Ubiquitin conjugating enzymes 7, 8 and 9
    21.
    发明授权
    Ubiquitin conjugating enzymes 7, 8 and 9 失效
    泛素缀合酶7,8和9

    公开(公告)号：US5945321A

    公开(公告)日：1999-08-31

    申请号：US875272

    申请日：1997-10-02

    申请人： Jian Ni ,  Reiner L. Gentz ,  Mark D. Adams

    发明人： Jian Ni ,  Reiner L. Gentz ,  Mark D. Adams

    IPC分类号： C12N9/00 ,  C12N9/10

    CPC分类号： C12N9/93 ,  C12Y603/02019 ,  C07K2319/00 ,  C12N2799/026

    摘要： Human UCE 7, UCE 8 and UCE 9 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods of utilizing such polypeptides for the treatment of the porliferation of malignant cells. Antagonists against such polypeptides and their uses as a therapeutic to treat Alzheimer's disease, atrophying skeletal muscle, African Swine Fever Virus and apoptotic cell death are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in UCE 7, 8 and 9 nucleic acid sequences and to the concentration of polypeptides encoded by such sequences.

    摘要翻译： PCT No.PCT / US95 / 01250 Sec。 371 1997年10月2日第 102（e）日期1997年10月2日PCT提交1995年1月31日PCT公布。 出版物WO96 / 23410 PCT 日期1996年8月8日公开了人类UCE 7，UCE 8和UCE 9多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来治疗恶性细胞增殖的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗性阿尔茨海默氏病，萎缩性骨骼肌，非洲猪热病毒和凋亡性细胞死亡的治疗剂的用途。 还公开了用于检测与UCE7,8和9核酸序列中的突变有关的疾病的诊断测定和由这些序列编码的多肽的浓度。

    Human elastate IV
    23.
    发明授权
    Human elastate IV 失效
    人弹性蛋白酶IV

    公开(公告)号：US5851814A

    公开(公告)日：1998-12-22

    申请号：US765192

    申请日：1997-04-24

    申请人： John M. Green ,  Mark D. Adams

    发明人： John M. Green ,  Mark D. Adams

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/48 ,  A61K48/00 ,  A61P1/00 ,  A61P1/04 ,  A61P3/06 ,  A61P9/10 ,  A61P9/14 ,  A61P29/00 ,  A61P31/04 ,  C07H21/04 ,  C07K16/40 ,  C12N1/21 ,  C12N9/64 ,  C12N9/66 ,  C12N9/99 ,  C12N15/12 ,  C12N15/57 ,  C12Q1/68 ,  C12R1/19 ,  C07K2/00

    CPC分类号： C12N9/6424 ,  A61K38/00

    摘要： Human elastase IV polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, restoration of elasticity of arterial walls, improvement of serum lipid abnormality and improvement of serum lipoprotein metabolism are disclosed. Also disclosed are antagonist/inhibitors against such polypeptides and their use in treating inflammation, arthritis, e.g. rheumatoid arthritis and osteoarthritis, septic shock, pancreatitis and limiting tissue damage in ulceration. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

    摘要翻译： PCT No.PCT / US95 / 07236 Sec。 371日期1997年04月24日 102（e）日期1997年4月24日PCT Filed June 6，1995 PCT Pub。 出版物WO96 / 01270 日期1996年1月18日编码这种多肽的人弹性蛋白酶IV多肽和DNA（RNA）和通过重组技术产生这种多肽的方法并利用这种多肽用于治疗目的，例如恢复动脉壁的弹性，改善血清脂质异常 并公开了血清脂蛋白代谢的改善。 还公开了针对这种多肽的拮抗剂/抑制剂及其在治疗炎症，关节炎等中的用途。 类风湿关节炎和骨关节炎，脓毒性休克，胰腺炎和限制溃疡组织损伤。 还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。

    Human oxalyl-CoA decarboxylase
    24.
    发明授权
    Human oxalyl-CoA decarboxylase 失效
    人类草酰辅酶A脱羧酶

    公开(公告)号：US5635616A

    公开(公告)日：1997-06-03

    申请号：US458120

    申请日：1995-06-02

    申请人： Henrik S. Olsen ,  Timothy A. Coleman ,  Mark D. Adams

    发明人： Henrik S. Olsen ,  Timothy A. Coleman ,  Mark D. Adams

    IPC分类号： A61K38/00 ,  C12N9/88 ,  C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12P21/04

    CPC分类号： C12N9/88 ,  C12Q1/6883 ,  A61K38/00 ,  C12Q2600/156

    摘要： A human oxalyl-CoA decarboxylase polypeptide and DNA(RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide are disclosed. Also disclosed is a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of urolithiasis and hyperoxaluria. Also disclosed are assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention.

    摘要翻译： 公开了人草酰-CoA脱羧酶多肽和编码这种多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法和用于产生抗这种多肽的抗体。 还公开了本发明的多肽与合适的药物载体的组合，用于提供治疗有效量的多肽用于治疗尿石症和高硫酸尿症。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并检测本发明多肽的改变水平的测定。

    Antibodies to human chemokine beta-9
    28.
    发明授权
    Antibodies to human chemokine beta-9 有权
    人趋化因子β-9的抗体

    公开(公告)号：US07097985B2

    公开(公告)日：2006-08-29

    申请号：US10329472

    申请日：2002-12-27

    申请人： Haodong Li ,  Mark D. Adams

    发明人： Haodong Li ,  Mark D. Adams

    IPC分类号： G01N33/53 ,  C07K16/24 ,  C12N5/12

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/523 ,  G01N33/564 ,  G01N33/57426 ,  G01N33/6863 ,  G01N2333/52

    摘要： Human Ckβ-9 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Ckβ-9 polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the Ckβ-9 coding sequence and over-expression of the Ckβ-9 protein.

    摘要翻译： 公开了人Ckbeta-9多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种Ckbeta-9多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了诊断测定法，其检测Ckbeta-9编码序列中突变的存在和Ckbeta-9蛋白的过表达。

    Connective tissue growth factor-2
    29.
    发明授权
    Connective tissue growth factor-2 失效

    公开(公告)号：US06534630B1

    公开(公告)日：2003-03-18

    申请号：US09348815

    申请日：1999-07-08

    申请人： Haodong Li ,  Mark D. Adams

    发明人： Haodong Li ,  Mark D. Adams

    IPC分类号： C07K100

    CPC分类号： C07K14/475 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K2319/00

    摘要： The present invention relates to a human CTGF-2 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist/inhibitors against such polypeptide. Also provided are methods of using the polypeptide therapeutically for enhancing the repair of connective and support tissue, promoting the attachment, fixation and stabilization of tissue implants and enhancing wound healing. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.