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公开(公告)号：US20090012034A1
公开(公告)日：2009-01-08
申请号：US12214651
申请日：2008-06-20
申请人： Todd Richard Elworthy , Joan Heather Hogg , Joshua Kennedy-Smith , Counde O'Yang , Mark Smith , Zachary Kevin Sweeney , Jeffrey Wu
发明人： Todd Richard Elworthy , Joan Heather Hogg , Joshua Kennedy-Smith , Counde O'Yang , Mark Smith , Zachary Kevin Sweeney , Jeffrey Wu
IPC分类号： A61K31/708 , C07D235/26 , A61K31/4184 , C07D471/04 , A61P31/18 , A61K31/437 , A61K31/5025 , C07D487/04
CPC分类号： C07D235/26 , C07D471/04 , C07D487/04
摘要： Compounds of formula I, wherein R1, R2, R3, X and Ar, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
摘要翻译： 其中R 1，R 2，R 3，X和Ar如本文所定义的式I化合物或其药学上可接受的盐抑制HIV-1逆转录酶，并提供预防和治疗HIV-1感染和治疗AIDS的方法 和/或ARC。 本发明还涉及含有用于预防和治疗HIV-1感染和治疗AIDS和/或ARC的式I化合物的组合物。
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公开(公告)号：US07189718B2
公开(公告)日：2007-03-13
申请号：US10807993
申请日：2004-03-23
申请人： James Patrick Dunn , Brian William Dymock , Taraneh Mirzadegan , Eric Brian Sjogren , Steven Swallow , Zachary Kevin Sweeney
发明人： James Patrick Dunn , Brian William Dymock , Taraneh Mirzadegan , Eric Brian Sjogren , Steven Swallow , Zachary Kevin Sweeney
IPC分类号： C07D237/14 , C07D237/22 , A61K31/501
CPC分类号： C07D401/12 , C07D237/14 , C07D237/22 , C07D405/06 , C07D409/06
摘要： This invention relates to novel pyridazinone derivatives of formula I wherein R1–R4, R7, R8 and X1 are as defined in the summary and pharmaceutically acceptable salts and solvates thereof, methods to inhibit or modulate Human Immunodeficiency Virus (HIV) reverse transcriptase with compounds of formula I, pharmaceutical compositions containing of formula I admixed with at least one solvent, carrier or excipient and processes to prepare compounds of formula I. The compounds are useful for treating disorders in which HIV and genetically related viruses are implicated
摘要翻译： 本发明涉及式I的新的哒嗪酮衍生物，其中R 1，R 2，R 4，R 7，R 8， 和其中X 1如本发明概述及其药学上可接受的盐和溶剂合物中所定义，用式I化合物抑制或调节人类免疫缺陷病毒（HIV）逆转录酶的方法，含有式I的药物组合物 与至少一种溶剂，载体或赋形剂反应，并制备式I化合物。该化合物可用于治疗涉及HIV和遗传相关病毒的疾病
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公开(公告)号：US20150306172A1
公开(公告)日：2015-10-29
申请号：US14717872
申请日：2015-05-20
申请人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
发明人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, and A-B are as defined herein, which are non-immunosuppressive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
摘要翻译： 本发明提供式I化合物; 或其药学上可接受的盐，其中R1，R2，R3，R4，R5和AB如本文所定义，其为非免疫抑制性，亲环蛋白结合，mPTP阻断剂，因此可用于预防或治疗疾病或病症 例如HCV感染，中风，多发性硬化，HBV感染，HPV感染，哮喘，癌症，肌营养不良，败血症，缺血/再灌注损伤和心力衰竭。
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公开(公告)号：US09072696B2
公开(公告)日：2015-07-07
申请号：US14037644
申请日：2013-09-26
申请人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
发明人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, and A-B are defined herein, which are non-immunosuppresive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
摘要翻译： 本发明提供式I化合物; 或其药学上可接受的盐，其中本文定义的变量R1，R2，R3，R4，R5和AB是非免疫抑制性亲环蛋白结合的mPTP阻断剂，因此可用于预防或治疗疾病或 疾病如HCV感染，中风，多发性硬化，HBV感染，HPV感染，哮喘，癌症，肌营养不良，败血症，缺血/再灌注损伤和心力衰竭。
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公开(公告)号：US08063064B2
公开(公告)日：2011-11-22
申请号：US12708466
申请日：2010-02-18
IPC分类号： C07D471/04 , A61K31/437 , A61P31/18
CPC分类号： C07D471/04 , C07D231/12 , C07D231/56 , C07D487/04
摘要： The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein A is A2 and R1, R2, R3, R4a, R4b, R5, R6, Ar, X1, X2, X4, X4 and X5 are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.
摘要翻译： 本发明提供了可用于治疗HIV感染或预防HIV感染或治疗AIDS或ARC的化合物。 本发明化合物是式Ⅰ化合物，其中A是A2，R 1，R 2，R 3，R 4a，R 4b，R 5，R 6，Ar，X 1，X 2，X 4，X 4和X 5如本文所定义。 本发明还公开了用本文定义的化合物治疗HIV感染的方法和含有所述化合物的药物组合物。
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公开(公告)号：US20110059975A1
公开(公告)日：2011-03-10
申请号：US12708466
申请日：2010-02-18
IPC分类号： A61K31/5025 , C07D231/12 , A61K31/415 , C07D231/56 , A61K31/416 , C07D471/04 , A61K31/437 , C07D487/04 , A61K31/519 , A61K31/4985 , C07D237/24 , A61K31/50 , A61P31/18
CPC分类号： C07D471/04 , C07D231/12 , C07D231/56 , C07D487/04
摘要： The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein A is A2 and R1, R2, R3, R4a, R4b, R5, R6, Ar, X1, X2, X4, X4 and X5 are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.
摘要翻译： 本发明提供了可用于治疗HIV感染或预防HIV感染或治疗AIDS或ARC的化合物。 本发明化合物是式Ⅰ化合物，其中A是A2，R 1，R 2，R 3，R 4a，R 4b，R 5，R 6，Ar，X 1，X 2，X 4，X 4和X 5如本文所定义。 本发明还公开了用本文定义的化合物治疗HIV感染的方法和含有所述化合物的药物组合物。
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公开(公告)号：US07625949B2
公开(公告)日：2009-12-01
申请号：US11112590
申请日：2005-04-22
IPC分类号： A61K31/18 , A61K31/165 , A61K31/33 , A61K31/497 , A61K31/435 , A61K31/44 , A61K31/40 , A61K31/405
CPC分类号： A61K31/277
摘要： The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R1-R5, R11c and X1 are as defined herein.
摘要翻译： 本发明提供用于治疗或预防HIV感染或治疗AIDS或ARC的化合物，其包括给予式I化合物，其中Ar，R 1 -R 5，R 11c和X 1如本文所定义。
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公开(公告)号：US07625897B2
公开(公告)日：2009-12-01
申请号：US11541011
申请日：2006-09-29
IPC分类号： C07D253/06 , A61K31/53 , A61P31/18
CPC分类号： C07D237/04 , C07D237/02 , C07D253/06 , C07D253/07 , C07D273/04
摘要： The present invention provides compounds of formula I where R1 to R4 are as defined herein which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides for methods of treating or preventing HIV infection with compounds according to formula I and compositions containing the same. The invention still further provides process for the preparation of compounds of formula I wherein R4 is A1 and X1 is NH or O.
摘要翻译： 本发明提供式I化合物，其中R 1至R 4如本文所定义，其可用于治疗或预防人类免疫缺陷病毒（HIV）感染或治疗AIDS或ARC。 本发明进一步提供了用式I化合物和含有该化合物的组合物治疗或预防HIV感染的方法。 本发明还提供制备其中R 4为Al且X 1为NH或O的式I化合物的方法。
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公开(公告)号：US20090170856A1
公开(公告)日：2009-07-02
申请号：US12341594
申请日：2008-12-22
IPC分类号： A61K31/437 , C07D471/04 , C07D487/04 , A61K31/5025 , A61P31/18
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds of formula I, wherein R1, R2, R3, X1, X2 and Ar, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
摘要翻译： 其中R 1，R 2，R 3，X 1，X 2和Ar如本文所定义或其药学上可接受的盐的式I化合物抑制HIV-1逆转录酶，并提供预防和治疗HIV-1感染和治疗的方法 的艾滋病和/或ARC。 本发明还涉及含有用于预防和治疗HIV-1感染和治疗AIDS和/或ARC的式I化合物的组合物。
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公开(公告)号：US20090076045A1
公开(公告)日：2009-03-19
申请号：US12156228
申请日：2008-05-30
IPC分类号： A61K31/513 , C07D239/54 , C07D233/74 , A61K31/4166 , A61P31/18
CPC分类号： C07D239/22 , C07D233/72 , C07D233/78 , C07D239/54 , C07D239/545 , C07D239/553
摘要： Compounds of formula I, wherein R1, X1, X2 and A, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
摘要翻译： 其中R1，X1，X2和A如本文所定义的式I化合物或其药学上可接受的盐抑制HIV-1逆转录酶，并提供预防和治疗HIV-1感染的方法以及治疗AIDS和/ 或ARC。 本发明还涉及含有用于预防和治疗HIV-1感染和治疗AIDS和/或ARC的式I化合物的组合物。
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