公开(公告)号：US06511979B1

公开(公告)日：2003-01-28

申请号：US09359023

申请日：1999-07-22

Applicant: Subroto Chatterjee

Inventor： Subroto Chatterjee

IPC: A61K31535

CPC classification number: A61K38/1858 ,  A61K31/00 ,  A61K31/16 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/5375 ,  A61K38/1709 ,  A61K38/191 ,  A61K2300/00

Abstract: The present invention includes methods for treatment and prophylaxis of conditions associated with lactosylceramide. The methods generally provide for administration to a mammal, particularly a human, of a therapeutically effective amount of a compound that increases enzymatic activity of UDPGal:GlcCer&bgr;1→4 galactosylceramide (GalT-2). In vitro and in vivo assays for detecting compounds with therapeutic capacity to modulate GalT-2 are also provided.

Abstract translation: 本发明包括用于治疗和预防与乳糖神经酰胺相关的病症的方法。 所述方法通常提供给哺乳动物，特别是人类施用治疗有效量的增加UDPGal：GlcCerbeta1-4半乳糖神经酰胺（GalT-2）的酶活性的化合物。 还提供了用于检测具有调节GalT-2的治疗能力的化合物的体外和体内测定。