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公开(公告)号：US20160201046A1
公开(公告)日：2016-07-14
申请号：US15082635
申请日：2016-03-28
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
IPC: C12N9/52
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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公开(公告)号：US09297003B2
公开(公告)日：2016-03-29
申请号：US14088022
申请日：2013-11-22
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
Abstract translation: 本说明书公开了包含灭活切割位点的梭菌毒素或梭菌毒素嵌合体，编码这种毒素或嵌合体的多核苷酸分子，包含这种毒素或嵌合体的组合物，以及产生此类毒素或嵌合体的方法。
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23.发明申请公开(公告)号：US20150197739A1
公开(公告)日：2015-07-16
申请号：US14422574
申请日：2013-08-27
Applicant: Syntaxin Limited , Allergan, Inc.
Inventor： Peter James , Keith Foster , John Chaddock , Roger Kei Aoki , Lance Steward , Joseph Francis
IPC: C12N9/52 , C07K14/575
Abstract: A single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, which protease is capable of cleaving a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a galanin Targeting Moiety that is capable of binding to a Binding Site on the nociceptive sensory afferent, which Binding Site is capable of undergoing endocytosis to be incorporated into an endosome within the nociceptive sensory afferent; a protease cleavage site at which site the fusion protein is cleavable by a protease, wherein the protease cleavage site is located between the non-cytotoxic protease and the galanin Targeting Moiety; a translocation domain that is capable of translocating the protease from within an endosome, across the endosomal membrane and into the cytosol of the nociceptive sensory afferent; a first spacer located between the non-cytotoxic protease and the protease cleavage site, wherein said first spacer comprises an amino acid sequence of from 4 to 25 amino acid residues; and a second spacer located between the galanin Targeting Moiety and the translocation domain, wherein said second spacer comprises an amino acid sequence of from 4 to 35 amino acid residues. Nucleic acid sequences encoding the polypeptide fusion proteins, methods of preparing same and uses thereof are also described.
Abstract translation: 一种单链多肽融合蛋白，其包含：非细胞毒性蛋白酶，该蛋白酶能够切割伤害性感觉传入的胞外融合装置的蛋白质; 能够结合伤害性感觉传入物的结合位点的甘丙肽靶向部位，该结合位点能够经受内吞作用以掺入伤害性感觉传入内的内体; 蛋白酶切割位点，其中融合蛋白可被蛋白酶切割，其中蛋白酶切割位点位于非细胞毒性蛋白酶和甘丙肽靶向部位之间; 能够将位于内体内的蛋白酶从内体膜转移到伤害性感觉传入体的胞质溶胶中的易位结构域; 位于所述非细胞毒性蛋白酶和所述蛋白酶切割位点之间的第一间隔物，其中所述第一间隔物包含4至25个氨基酸残基的氨基酸序列; 和位于甘丙肽靶向部位和易位结构域之间的第二间隔物，其中所述第二间隔物包含4至35个氨基酸残基的氨基酸序列。 还描述了编码多肽融合蛋白的核酸序列，其制备方法及其用途。
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公开(公告)号：US08685692B2
公开(公告)日：2014-04-01
申请号：US13846307
申请日：2013-03-18
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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公开(公告)号：US20240018500A1
公开(公告)日：2024-01-18
申请号：US17934914
申请日：2022-09-23
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Femandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
CPC classification number: C12N9/52 , A61K38/4893 , C12Y304/24069 , C07K14/33
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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Patent Agency Ranking
公开(公告)号：US20190317095A1
公开(公告)日：2019-10-17
申请号：US16441472
申请日：2019-06-14
Applicant: Allergan, Inc.
Inventor： Ron S. Broide , Brian Cai , Ester Fernandez-Salas , Joseph Francis , Catherine Rheaume
IPC: G01N33/573 , C07K16/18
Abstract: Methods and compositions for detecting BoNT/A enzymatic activity in tissues or a tissue sample are described herein. The invention encompasses antibodies that bind preferentially to BoNT/A cleaved SNAP25 and is able to preferentially detect BoNT/A cleaved SNAP25, as compared to intact (non-cleaved) SNAP25, in a tissue sample.
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公开(公告)号：US09943576B2
公开(公告)日：2018-04-17
申请号：US14700390
申请日：2015-04-30
Applicant: Allergan, Inc.
Inventor： Eric A. Forssen , Patrick M. Hughes , David C. Rupp , Terrence Hunt , Gary Shimizu , Joseph Francis , Ron S. Broide , Ester Fernandez-Salas
CPC classification number: A61K38/4893 , A61K9/0034 , A61K38/164 , A61K47/10 , A61K47/34 , A61K47/36 , C12Y304/24069
Abstract: Pharmaceutical formulations comprising a clostridial derivative and a permeabilizing agent for intravesical instillation are disclosed.
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公开(公告)号：US09284545B2
公开(公告)日：2016-03-15
申请号：US14087952
申请日：2013-11-22
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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公开(公告)号：US09279116B2
公开(公告)日：2016-03-08
申请号：US14086840
申请日：2013-11-21
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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公开(公告)号：US20160003824A1
公开(公告)日：2016-01-07
申请号：US14792795
申请日：2015-07-07
Applicant: Allergan, Inc.
Inventor： Ron S. Broide , Brian Cai , Ester Fernandez-Salas , Joseph Francis , Catherine Rheaume
IPC: G01N33/573 , C07K16/18
Abstract: Methods and compositions for detecting BoNT/A enzymatic activity in tissues or a tissue sample are described herein. The invention encompasses antibodies that bind preferentially to BoNT/A cleaved SNAP25 and is able to preferentially detect BoNT/A cleaved SNAP25, as compared to intact (non-cleaved) SNAP25, in a tissue sample.
Abstract translation: 本文描述了用于检测组织或组织样品中BoNT / A酶活性的方法和组合物。 本发明包括优先结合BoNT / A切割的SNAP25的抗体，并且与组织样品中完整的（未切割的）SNAP25相比，能够优先检测BoNT / A切割的SNAP25。
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