公开(公告)号：US20150374696A1

公开(公告)日：2015-12-31

申请号：US14728105

申请日：2015-06-02

Applicant: The Board of Regents of the University of Texas System

Inventor： Lawrence LUM ,  Michael G. ROTH ,  Baozhi CHEN ,  Chuo CHEN ,  Michael E. DODGE ,  Wei TANG

IPC: A61K31/519 ,  A61K31/502 ,  A61K45/06

CPC classification number: A61K31/519 ,  A61K31/502 ,  A61K45/06 ,  C07D209/48 ,  C07D209/94 ,  C07D239/54 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D413/04 ,  C07D417/12 ,  C07D471/04 ,  C07D519/00

Abstract: The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.