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21.发明申请METHODS AND DEVICES FOR REGULATING THE ACTIVATION OF GHRELIN HORMONES WITHIN A STOMACH 有权调节GHRELIN HORMONES在STOMACH中激活的方法和装置公开(公告)号：US20110295286A1
公开(公告)日：2011-12-01
申请号：US13105006
申请日：2011-05-11
IPC分类号： A61B17/11
CPC分类号： A61F5/0076 , A61B2017/0404 , A61F5/0083
摘要： Methods and devices regulate the activation of ghrelin hormones within a stomach in order to treat weight disorders, to promote learning and memory functions, to treat stress-induced depression, and to control sleep duration. In one embodiment, a method for regulating activation of ghrelin hormones within a stomach comprises a means for isolating non-activated ghrelin hormones from food content and dietary lipids within the stomach. These means for isolating may take any number of forms and may comprise one or more of a surgical procedure, an implanted device, or an ingestible substance.
摘要翻译： 方法和装置调节胃内生长素释放激素的激活，以治疗体重紊乱，促进学习和记忆功能，治疗压力诱导的抑郁症和控制睡眠持续时间。 在一个实施方案中，用于调节胃内生长素释放激素激活的方法包括从胃中的食物含量和膳食脂质中分离未活化的生长素释放肽激素的方法。 这些用于隔离的装置可以采取任何数量的形式，并且可以包括外科手术，植入装置或可摄取物质中的一种或多种。
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22.发明申请公开(公告)号：US20110295179A1
公开(公告)日：2011-12-01
申请号：US13105014
申请日：2011-05-11
IPC分类号： A61M5/00
CPC分类号： A61F5/0083 , A61F5/0076
摘要： Methods and devices regulate the activation of ghrelin hormones within a stomach in order to treat weight disorders, to promote learning and memory functions, to treat stress-induced depression, and to control sleep duration. In one embodiment, a method for regulating activation of ghrelin hormones within a stomach comprises a means for isolating non-activated ghrelin hormones from food content and dietary lipids within the stomach. These means for isolating may take any number of forms and may comprise one or more of a surgical procedure, an implanted device, or an ingestible substance.
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公开(公告)号：US20130075447A1
公开(公告)日：2013-03-28
申请号：US13240141
申请日：2011-09-22
申请人： William B. Weisenburgh, II , Craig S. Smith , Gregory B. Blair , Zhifan F. Huang , Douglas B. Hoffman , Kristi S. Geier , Bret W. Smith , Thomas W. Lytle, IV , Mark D. Overmyer , Brian W. Bear , Michael E. Setser , Thu Anh Le , James A. Woodard, JR. , Kreena R. Modi , Joseph Zavatsky
发明人： William B. Weisenburgh, II , Craig S. Smith , Gregory B. Blair , Zhifan F. Huang , Douglas B. Hoffman , Kristi S. Geier , Bret W. Smith , Thomas W. Lytle, IV , Mark D. Overmyer , Brian W. Bear , Michael E. Setser , Thu Anh Le , James A. Woodard, JR. , Kreena R. Modi , Joseph Zavatsky
IPC分类号： A61B17/068
CPC分类号： A61B17/00491 , A61B17/07207 , A61B17/07292 , A61B2017/00495 , A61B2017/00893 , A61B2017/07228 , A61B2017/07257 , A61B2017/07271 , A61B2017/2927 , A61B2017/320052
摘要： A surgical instrument includes a handle portion, a shaft housing a firing bar, an end effector comprising an anvil, a lower jaw, and a stapling and severing assembly responsive to a longitudinal closing motion produced by the handle portion and the shaft. The lower jaw is configured to receive a removable cartridge. The cartridge includes a housing, a plurality of staples disposed in the housing, and a deck disposed over the plurality of staples. The deck defines apertures, with each aperture being substantially disposed over each staple. The cartridge further receives a buttress material stored in one or both of the anvil or cartridge. The material is releasable onto severed tissue via a firing bar severing the buttress material in response to the longitudinal closing motion.
摘要翻译： 手术器械包括手柄部分，容纳击球杆的轴，包括砧座的末端执行器，下颚和响应于由手柄部分和轴产生的纵向关闭运动的装订和切割组件。 下颌构造成接收可移除的盒。 盒包括壳体，设置在壳体中的多个钉，以及设置在多个钉上的甲板。 甲板限定孔，每个孔基本上设置在每个钉上。 该盒还容纳存储在一个或两个砧座或盒中的支撑材料。 该材料通过响应于纵向关闭运动切断支撑材料的击发杆而可拆卸到切断的组织上。
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公开(公告)号：US20130041406A1
公开(公告)日：2013-02-14
申请号：US13206725
申请日：2011-08-10
IPC分类号： A61B17/064 , A61B17/068 , B05D3/02
CPC分类号： A61L31/10 , A61B2017/00526 , A61B2017/00845 , A61B2017/00884 , A61B2017/00893 , A61B2017/00942 , A61B2017/00951 , A61B2017/2927 , A61L2400/04 , C08L89/00
摘要： A medical fastener has a first, pre-deployment shape for loading into a surgical instrument, and a second, post-deployment shape for connecting tissue together, and includes a crown and a pair of legs, each leg substantially transversely extending from a respective end of the crown in the first, pre-deployment shape. A coating, such as a hemostatic agent, is applied to a fastener interior surface defined by interior surfaces of the crown and the pair of legs.
摘要翻译： 医疗紧固件具有用于装载到手术器械中的第一预先展开形状，以及用于将组织连接在一起的第二后部展开形状，并且包括冠部和一对腿部，每个腿部基本上从相应端部横向延伸 的皇冠在第一，预部署形状。 诸如止血剂的涂层施加到由表冠和一对腿的内表面限定的紧固件内表面。
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公开(公告)号：US08377079B2
公开(公告)日：2013-02-19
申请号：US11965322
申请日：2007-12-27
申请人： Jonathan A. Coe , Mark S. Ortiz , Kyle P. Moore , Mark D. Overmyer , Thomas E. Adams , Andrew M. Zwolinski
发明人： Jonathan A. Coe , Mark S. Ortiz , Kyle P. Moore , Mark D. Overmyer , Thomas E. Adams , Andrew M. Zwolinski
CPC分类号： A61F5/0056
摘要： Methods and devices are provided for regulating a restriction system. In one exemplary embodiment, a restriction system is provided having a restriction device coupled to a port with a fluid disposed in the device, such that the restriction device is adapted to form a restriction in a pathway corresponding to an amount of fluid contained in the device, and a pressure adjustment unit in communication with the port and effective to maintain a substantially constant equilibrium pressure between the pressure adjustment unit and the restriction device. The pressure adjustment unit is configured to regulate an amount of fluid in the restriction device in response to a fluid pressure acting on the device.
摘要翻译： 提供了用于调节限制系统的方法和装置。 在一个示例性实施例中，提供限制系统，其具有联接到具有设置在装置中的流体的端口的限制装置，使得限制装置适于在对应于包含在装置中的流体的量的通路中形成限制 以及与所述端口连通并且有效地在所述压力调节单元和所述限制装置之间保持基本恒定的平衡压力的压力调节单元。 压力调节单元构造成响应于作用在该装置上的流体压力来调节限制装置中的流体的量。
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公开(公告)号：US20090171378A1
公开(公告)日：2009-07-02
申请号：US11965322
申请日：2007-12-27
申请人： Jonathan A. Coe , Mark S. Ortiz , Kyle P. Moore , Mark D. Overmyer , Thomas E. Adams , Andrew M. Zwolinski
发明人： Jonathan A. Coe , Mark S. Ortiz , Kyle P. Moore , Mark D. Overmyer , Thomas E. Adams , Andrew M. Zwolinski
IPC分类号： A61B17/08
CPC分类号： A61F5/0056
摘要： Methods and devices are provided for regulating a restriction system. In one exemplary embodiment, a restriction system is provided having a restriction device coupled to a port with a fluid disposed therein, such that the restriction device is adapted to form a restriction in a pathway corresponding to an amount of fluid contained therein, and a pressure adjustment unit in communication with the port and effective to maintain a substantially constant equilibrium pressure between the pressure adjustment unit and the restriction device. The pressure adjustment unit is configured to regulate an amount of fluid in the restriction device in response to a fluid pressure acting thereon.
摘要翻译： 提供了用于调节限制系统的方法和装置。 在一个示例性实施例中，提供限制系统，其具有联接到具有设置在其中的流体的端口的限制装置，使得限制装置适于在对应于其中容纳的流体的量的通路中形成限制，并且压力 调节单元与端口连通并且有效地在压力调节单元和限制装置之间保持基本恒定的平衡压力。 压力调节单元构造成响应于作用在其上的流体压力来调节限制装置中的流体的量。
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公开(公告)号：US09492170B2
公开(公告)日：2016-11-15
申请号：US13206752
申请日：2011-08-10
申请人： Brian W. Bear , Thu Anh Le , Thomas W. Lytle, IV , Mark D. Overmyer , Michael Setser , Bret W. Smith , Joseph Zavatsky , Kreena Modi
发明人： Brian W. Bear , Thu Anh Le , Thomas W. Lytle, IV , Mark D. Overmyer , Michael Setser , Bret W. Smith , Joseph Zavatsky , Kreena Modi
IPC分类号： A61B17/04 , A61B17/10 , A61B17/072 , A61B17/00 , A61B17/29
CPC分类号： A61B17/07207 , A61B17/07292 , A61B2017/00495 , A61B2017/00893 , A61B2017/07271 , A61B2017/2927
摘要： A modular end effector delivers a therapeutic agent onto tissue that has been severed and/or stapled. The end effector is removably attached to a device. The device applies force to a piston of the end effector. The force causes a distal movement of a piston along a wall disposed within the end effector. The piston engages with agents stored on opposite sides of the wall, moving the agents distally to a mixture space. The agents are mixed in the mixture space and expelled through a tip. Staples may be embedded in or disposed below a foam block, which is disposed within a staple cartridge. Via an endoscopic stapling device, coated staples are driven through tissue while interacting with another agent on the device or the cartridge. The interaction forms a tissue restoring material that is applied onto the tissue.
摘要翻译： 模块化的末端执行器将治疗剂递送到已被切断和/或装订的组织上。 端部执行器可拆卸地连接到装置。 该装置对末端执行器的活塞施加力。 该力导致活塞沿着设置在末端执行器内的壁的远端移动。 活塞与存储在壁的相对侧上的试剂接合，将试剂向远端移动到混合物空间。 将试剂在混合物空间中混合并通过尖端排出。 钉书钉可以嵌入或设置在布置在钉仓内的泡沫块的下方。 通过内窥镜缝合装置，当与装置或药筒上的另一药剂相互作用时，涂布的钉被驱动通过组织。 相互作用形成施加到组织上的组织恢复材料。
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公开(公告)号：US20090216255A1
公开(公告)日：2009-08-27
申请号：US12037261
申请日：2008-02-26
IPC分类号： A61B17/08
CPC分类号： A61F5/0053
摘要： Methods and devices are provided for regulating a hydraulic restriction system. In general, the methods and devices can allow for non-invasive pressure control using a flow control mechanism. The flow control mechanism can be disposed between an implantable restriction device and a fluid source and include an adjustable, variably-sized fluid communication member in fluid communication with the restriction device and the fluid source. The geometry of the fluid communication member can control a rate of fluid flow between the restriction device and the fluid source, thereby also regulating a rate at which a pressure of fluid within the restriction device changes. Alternatively, the fluid flow control mechanism can include a biasing mechanism that can control the rate of fluid flow between the restriction device and the fluid source.
摘要翻译： 提供了用于调节液压限制系统的方法和装置。 通常，方法和装置可以允许使用流量控制机构的非侵入性压力控制。 流量控制机构可以设置在可植入的限制装置和流体源之间，并且包括与限制装置和流体源流体连通的可调节的可变尺寸的流体连通构件。 流体连通构件的几何形状可以控制限制装置和流体源之间的流体流动速率，从而也可以调节限制装置内的流体的压力变化的速率。 或者，流体流动控制机构可以包括偏置机构，其可以控制限制装置和流体源之间的流体流动速率。
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公开(公告)号：US20130037596A1
公开(公告)日：2013-02-14
申请号：US13206752
申请日：2011-08-10
申请人： Brian W. Bear , Thu Anh Le , Thomas W. Lytle, IV , Mark D. Overmyer , Michael Setser , Bret W. Smith , Joseph Zavatsky , Kreena Modi
发明人： Brian W. Bear , Thu Anh Le , Thomas W. Lytle, IV , Mark D. Overmyer , Michael Setser , Bret W. Smith , Joseph Zavatsky , Kreena Modi
IPC分类号： A61B17/068
CPC分类号： A61B17/07207 , A61B17/07292 , A61B2017/00495 , A61B2017/00893 , A61B2017/07271 , A61B2017/2927
摘要： A modular end effector delivers a therapeutic agent onto tissue that has been severed and/or stapled. The end effector is removably attached to a device. The device applies force to a piston of the end effector. The force causes a distal movement of a piston along a wall disposed within the end effector. The piston engages with agents stored on opposite sides of the wall, moving the agents distally to a mixture space. The agents are mixed in the mixture space and expelled through a tip. Staples may be embedded in or disposed below a foam block, which is disposed within a staple cartridge. Via an endoscopic stapling device, coated staples are driven through tissue while interacting with another agent on the device or the cartridge. The interaction forms a tissue restoring material that is applied onto the tissue.
摘要翻译： 模块化的末端执行器将治疗剂递送到已被切断和/或装订的组织上。 端部执行器可拆卸地连接到装置。 该装置对末端执行器的活塞施加力。 该力导致活塞沿着设置在末端执行器内的壁的远端移动。 活塞与存储在壁的相对侧上的试剂接合，将试剂向远端移动到混合物空间。 将试剂在混合物空间中混合并通过尖端排出。 钉书钉可以嵌入或设置在布置在钉仓内的泡沫块的下方。 通过内窥镜缝合装置，当与装置或药筒上的另一药剂相互作用时，涂布的钉被驱动通过组织。 相互作用形成施加到组织上的组织恢复材料。
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公开(公告)号：US20090171379A1
公开(公告)日：2009-07-02
申请号：US11965334
申请日：2007-12-27
申请人： Jonathan A. Coe , Kyle P. Moore , Andrew M. Zwolinski , Thomas E. Adams , Robert Jason Simms , JoAnn M. Stegeman , Christopher W. Widenhouse , Juan S. Ezolino , Mark D. Overmyer
发明人： Jonathan A. Coe , Kyle P. Moore , Andrew M. Zwolinski , Thomas E. Adams , Robert Jason Simms , JoAnn M. Stegeman , Christopher W. Widenhouse , Juan S. Ezolino , Mark D. Overmyer
IPC分类号： A61B17/08
CPC分类号： A61F5/0056
摘要： Methods and devices are provided for regulating a restriction system. In one exemplary embodiment, a restriction system is provided having a restriction device configured to receive fluid and to form a restriction in a pathway corresponding to an amount of fluid contained therein, at least one fluid reservoir, and a fluid logic system coupled between the restriction device and the at least one fluid reservoir. The fluid logic system is configured to regulate an amount of fluid in the restriction device in response to a fluid pressure acting thereon.
摘要翻译： 提供了用于调节限制系统的方法和装置。 在一个示例性实施例中，提供限制系统，其具有限制装置，其被配置为接收流体并且在对应于其中容纳的流体的量的通路中形成限制，至少一个流体储存器和耦合在所述限制 装置和至少一个流体储存器。 流体逻辑系统构造成响应于作用在其上的流体压力来调节限制装置中的流体的量。
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