公开(公告)号：US20050256336A1

公开(公告)日：2005-11-17

申请号：US10510927

申请日：2003-04-14

申请人： Paul Sutton

发明人： Paul Sutton

IPC分类号： A61P3/10 ,  A61K31/195 ,  A61K31/198 ,  C07C231/22 ,  C07C231/24 ,  C07C233/63 ,  C07C235/70

CPC分类号： C07C233/63 ,  C07B2200/13 ,  C07C231/22 ,  C07C2601/14

摘要： New crystal forms of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine, also known as nateglinide, may be produced by dissolving nateglinide in any of its forms, including solvates, in an organic solvent to form a solution followed by precipitation of nateglinide from the solution, and isolating and drying the precipitated crystal form of nateglinide. The precipitation of nateglinide may be induced either by cooling the solution, or by addition of another solvent which is miscible with the first solvent but in which nateglinide is only poorly soluble, or by combination of the two. Depending on the solvent a specific crystal form of nateglinide may be obtained, e.g., the R′-type crystal form of nateglinide produced by the described method has a different melting point, infra red spectra and X-ray diffraction patterns from the previously known crystal forms of nateglinide.

摘要翻译： N-（反式-4-异丙基环己基羰基）-D-苯丙氨酸（也称为那格列奈）的新结晶形式可以通过将那格列奈以任何形式（包括溶剂化物）溶解在有机溶剂中来形成溶液，然后沉淀 那格列奈，并分离和干燥那格列奈沉淀的晶体形式。 那格列奈的沉淀可以通过冷却溶液，或通过加入与第一溶剂混溶但其中那格列奈仅溶于难溶性的另外的溶剂，或通过两者的组合来诱导。 取决于溶剂，可以获得那格列奈的特定结晶形式，例如，通过所述方法制备的那格列奈的R'型晶型具有不同的熔点，红外光谱和来自先前已知的晶体的X射线衍射图 那格列奈的形式

公开(公告)号：US20050234129A1

公开(公告)日：2005-10-20

申请号：US10507255

申请日：2003-03-10

申请人： Paul Sutton ,  Richard Vivilecchia ,  David Parker ,  Marilyn De La Cruz

发明人： Paul Sutton ,  Richard Vivilecchia ,  David Parker ,  Marilyn De La Cruz

IPC分类号： A61K45/00 ,  A61K31/192 ,  A61K31/198 ,  A61K31/205 ,  A61K31/7008 ,  A61P1/04 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P15/00 ,  A61P17/00 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P27/12 ,  C07C215/10 ,  C07C229/26 ,  C07C233/63 ,  C07C233/81

CPC分类号： A61K31/192 ,  C07C233/63 ,  C07C2601/14

摘要： The present invention relates to salts of organic acid, in particular salt of nateglinide, combined preparations comprising one or more salts of nateglinide and, optionally, one or more additional ingredients and the use thereof in pharmaceutical compositions for preventing or treating diabetes, cardiovascular diseases, or conditions associated therewith.

摘要翻译： 本发明涉及有机酸的盐，特别是那格列奈的盐，包含那格列奈的一种或多种盐，任选的一种或多种另外的成分的组合制剂及其用于预防或治疗糖尿病，心血管疾病的药物组合物中的用途， 或与之相关的条件。