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公开(公告)号:US20060100201A1
公开(公告)日:2006-05-11
申请号:US11255043
申请日:2005-10-20
申请人: Carl Illig , Shelley Ballentine , Jinsheng Chen , Sanath Meegalla , M. Jonathan Rudolph , Mark Wall , Kenneth Wilson , Renee DesJarlais , Carl Manthey , Christopher Flores , Christopher Molloy
发明人: Carl Illig , Shelley Ballentine , Jinsheng Chen , Sanath Meegalla , M. Jonathan Rudolph , Mark Wall , Kenneth Wilson , Renee DesJarlais , Carl Manthey , Christopher Flores , Christopher Molloy
IPC分类号: A61K31/541 , A61K31/5377 , A61K31/496 , C07D417/14 , C07D413/14 , C07D405/14
CPC分类号: C07D263/34 , C07D207/34 , C07D233/90 , C07D307/68 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12
摘要: The invention relates to compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.
摘要翻译: 本发明涉及式I化合物:其中A,X,R 2和W在本说明书中列出,以及其抑制蛋白酪氨酸的溶剂合物,水合物,互变异构体和药学上可接受的盐 激酶,特别是c-fms激酶。 治疗自身免疫性疾病的方法 和具有炎症成分的疾病; 治疗卵巢癌,子宫癌,乳腺癌,结肠癌,胃癌,毛细胞白血病和非小细胞肺癌的转移; 并治疗疼痛,包括由肿瘤转移或骨关节炎引起的骨骼疼痛,或内脏,炎症和神经源性疼痛; 还提供了骨质疏松症,佩吉特氏病和其它骨吸收介导包括关节炎,假体失败,溶骨性骨肉瘤,骨髓瘤以及与式I化合物对骨的肿瘤转移的其它疾病。
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公开(公告)号:US20050049274A1
公开(公告)日:2005-03-03
申请号:US10894940
申请日:2004-07-20
申请人: Mark Wall , Mark Player , Raymond Patch , Sanath Meegalla , Jian Liu , Carl Illig , Wing Cheung , Jinsheng Chen , Davoud Asgari
发明人: Mark Wall , Mark Player , Raymond Patch , Sanath Meegalla , Jian Liu , Carl Illig , Wing Cheung , Jinsheng Chen , Davoud Asgari
IPC分类号: A61P35/00 , C07D215/22 , C07D215/227 , C07D401/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D471/02 , A61K31/47 , C07D215/36
CPC分类号: C07D215/227 , C07D401/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , Y02P20/582
摘要: The invention is directed to compounds of Formulae I and II: wherein R1, R2, R3, R5, R6, Y1, Y2, Y3, Y4 and X are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.
摘要翻译: 本发明涉及式I和II的化合物:其中R 1,R 2,R 3,R 5,R 6,Y 1,Y 2, 3>,Y 4和X在说明书中列出,以及其抑制蛋白酪氨酸激酶,特别是c-fms激酶的溶剂合物,水合物,互变异构体或其药学上可接受的盐。
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