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公开(公告)号:US5312823A
公开(公告)日:1994-05-17
申请号:US901056
申请日:1992-06-19
申请人: Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl-Georg Metzger , Hans-Joachim Zeiler
发明人: Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl-Georg Metzger , Hans-Joachim Zeiler
IPC分类号: A61K31/435 , A61K31/44 , A61K31/47 , A61K31/535 , A61P31/04 , C07D239/26 , C07D241/12 , C07D471/04 , C07D487/04 , C07D519/00 , A61K31/55
CPC分类号: C07D239/26 , C07D241/12 , C07D471/04 , C07D487/04
摘要: The invention relates to new quinolonecarboxylic acid derivatives which are substituted in the 7-position by an optionally partially hydrogenated azaisoindolinyl ring, to processes for their preparation, and to antibacterial agents and feed additives containing them.
摘要翻译: 本发明涉及通过任选的部分氢化的氮杂吲哚啉基环在7-位上被取代的新的喹诺酮羧酸衍生物,其制备方法以及含有它们的抗菌剂和饲料添加剂。
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22.Preparation of 7-(aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl) quinolonecarboxylic and 7-(aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl naphthyridonecarboxylic acid derivatives 失效
标题翻译: 制备7-(氨基甲基 - 氧杂-7-氮杂 - 双环[3.3.0]辛-7-基)喹啉酮羧酸和7-(氨基甲基 - 氧杂-7-氮杂 - 双环[3.3.0]辛-7-基萘啶酮 酸衍生物公开(公告)号:US5621105A
公开(公告)日:1997-04-15
申请号:US660022
申请日:1996-06-06
申请人: Uwe Petersen , Thomas Schenke , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl G. Metzger
发明人: Uwe Petersen , Thomas Schenke , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl G. Metzger
IPC分类号: A61K31/47 , A61K31/435 , A61K31/4375 , A61K31/4709 , A61K31/4741 , A61P31/04 , C07D491/04 , C07D491/048 , C07D519/00 , C07D471/04
CPC分类号: C07D491/04
摘要: ##STR1## in which Z represents a residue of the structure ##STR2## A represents N or C--R
5 . The end products are antibacterially active.摘要翻译:
+ TR 其中Z表示结构的残基,A表示N或C-R5。 最终产品具有抗菌活性。 -
23.7-(aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)quinolonecarboxylic and 7-(aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)naphthyridone-carboxylic acid intermediates 失效
标题翻译: 7-(氨基甲基 - 氧杂-7-氮杂 - 双环[3.3.0]辛-7-基)喹啉酮羧酸和7-(氨基甲基 - 氧杂-7-氮杂 - 双环[3.3.0]辛-7-基)萘啶酮 - 羧酸中间体公开(公告)号:US5395944A
公开(公告)日:1995-03-07
申请号:US124129
申请日:1993-09-20
申请人: Uwe Petersen , Thomas Schenke , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl G. Metzger
发明人: Uwe Petersen , Thomas Schenke , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl G. Metzger
IPC分类号: A61K31/47 , A61K31/435 , A61K31/4375 , A61K31/4709 , A61K31/4741 , A61P31/04 , C07D491/04 , C07D491/048 , C07D519/00 , C07D491/044
CPC分类号: C07D491/04
摘要: 7-(Aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)quinolonecarboxylic acid and 7-(aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)naphthyridonecarboxylic acid derivatives The invention relates to novel derivatives of quinolonecarboxylic acid and naphthyridonecarboxylic acid which are substituted in the 7 position by a 1- (or 5-)aminomethyl-2- (or 3-)oxa-7-aza-bicyclo[3.3.0]oct-7-yl residue, their salts, processes for their preparation and antibacterial agents containing these compounds.
摘要翻译: 7-(氨基甲基 - 氧杂-7-氮杂 - 双环[3.3.0]辛-7-基)喹啉酮羧酸和7-(氨基甲基 - 氧杂-7-氮杂 - 双环[3.3.0]辛-7-基)萘啶酮 酸衍生物本发明涉及由1-(或5-)氨基甲基-2-(或3-)氧杂-7-氮杂 - 双环[3.3.0%]取代的喹诺酮羧酸和萘啶酮酸的新衍生物 ]辛-7-基残基,其盐,其制备方法和含有这些化合物的抗菌剂。
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24.7-(aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)quinolonecarboxylic and 7-(aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl naphthyridonecarboxylic acid derivatives 失效
标题翻译: 7-(氨基甲基 - 氧杂-7-氮杂 - 双环[3.3.0]辛-7-基)喹啉酮羧酸和7-(氨基甲基 - 氧杂-7-氮杂 - 双环[3.3.0]辛-7-基萘啶酮羧酸衍生物公开(公告)号:US5574161A
公开(公告)日:1996-11-12
申请号:US320035
申请日:1994-10-07
申请人: Uwe Petersen , Thomas Schenke , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl G. Metzger
发明人: Uwe Petersen , Thomas Schenke , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl G. Metzger
IPC分类号: A61K31/47 , A61K31/435 , A61K31/4375 , A61K31/4709 , A61K31/4741 , A61P31/04 , C07D491/04 , C07D491/048 , C07D519/00 , A61K31/535 , A61K31/54 , C07D497/06 , C07D498/06
CPC分类号: C07D491/04
摘要: The invention relates to novel derivatives of quinolone-carboxylic acid and naphthyridonecarboxylic acid which are substituted in the 7 position by a 1- (or 5-)amino-methyl-2- (or 3-)oxa-7-aza-bicyclo[3.3.0]oct-7-yl residue, their salts, processes for their preparation and antibacterial agents containing these compounds.
摘要翻译: 本发明涉及喹诺酮羧酸和萘啶酮羧酸的新衍生物,其在7位被1-(或5-)氨基 - 甲基-2-(或3-)氧杂-7-氮杂 - 双环[3.3 0]辛-7-基残基,其盐,其制备方法和含有这些化合物的抗菌剂。
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公开(公告)号:US5457104A
公开(公告)日:1995-10-10
申请号:US180948
申请日:1994-01-12
申请人: Stephan Bartel , Andreas Krebs , Franz Kunisch , Uwe Petersen , Thomas Schenke , Klaus Grohe , Michael Schriewer , Klaus-Dieter Bremm , Rainer Endermann , Karl-Georg Metzger
发明人: Stephan Bartel , Andreas Krebs , Franz Kunisch , Uwe Petersen , Thomas Schenke , Klaus Grohe , Michael Schriewer , Klaus-Dieter Bremm , Rainer Endermann , Karl-Georg Metzger
IPC分类号: A23K1/16 , A01N43/42 , A01N43/90 , A61K31/435 , A61K31/47 , A61K31/535 , A61P31/04 , A61P33/00 , A61P33/02 , A61P33/10 , C07D215/233 , C07D401/04 , C07D405/12 , C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00 , C10M133/38 , C07D215/56
CPC分类号: C07D401/04 , A01N43/42 , A01N43/90 , C07D471/04 , C07D487/04 , C10M133/38
摘要: The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which have hydrogen in the 6-position, to processes for their preparation, and to antibacterial compositions and feed additives containing them.
摘要翻译: 本发明涉及在6-位具有氢的新喹诺酮和萘啶酮羧酸衍生物,其制备方法,以及含有它们的抗菌组合物和饲料添加剂。
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公开(公告)号:US5171854A
公开(公告)日:1992-12-15
申请号:US534791
申请日:1990-06-07
IPC分类号: A23K20/195 , C07D501/22
CPC分类号: C07D501/20 , A23K20/195 , C07D501/22 , C07D501/24
摘要: .beta.-Lactam compounds of the formula ##STR1## wherein R.sup.5 represent cyclopropyl or methyl, useful as antibiotics.
摘要翻译: 具有式“IMAGE”的β-内酰胺化合物,其中R 5表示可用作抗生素的环丙基或甲基。
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公开(公告)号:US4980348A
公开(公告)日:1990-12-25
申请号:US305317
申请日:1989-02-01
申请人: Gunter Schmidt , Wolfgang Hartwig , Wilfried Schrock , Rainer Endermann , Karl G. Metzger , Ingo Haller , Hans-Joachim Zeiler
发明人: Gunter Schmidt , Wolfgang Hartwig , Wilfried Schrock , Rainer Endermann , Karl G. Metzger , Ingo Haller , Hans-Joachim Zeiler
IPC分类号: A61K31/435 , A61P31/04 , C07D463/00
CPC分类号: C07D463/22
摘要: A heteroanellated phenylglycine-.beta.-lactam antibiotic of the formula ##STR1## in which R.sup.1 - stands for a radical of the formula ##STR2##
摘要翻译: 式(I)的杂原子化苯基甘氨酸-β-内酰胺抗生素,其中R1代表下式的基团:
+ TR -
28.
公开(公告)号:US5508278A
公开(公告)日:1996-04-16
申请号:US296944
申请日:1994-08-26
申请人: Thomas Jaetsch , Burkhard Mielke , Uwe Petersen , Thomas Philipps , Thomas Schenke , Klaus D. Bremm , Rainer Endermann , Karl G. Metzger , Martin Scheer , Michael Stegemann , Heinz-Georg Wetzstein
发明人: Thomas Jaetsch , Burkhard Mielke , Uwe Petersen , Thomas Philipps , Thomas Schenke , Klaus D. Bremm , Rainer Endermann , Karl G. Metzger , Martin Scheer , Michael Stegemann , Heinz-Georg Wetzstein
IPC分类号: A61K31/535 , A61K31/435 , A61K31/47 , A61P31/04 , C07D209/48 , C07D215/58 , C07D401/04 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04 , C07D498/06 , C07D519/00 , C07D273/04 , A01N43/88
CPC分类号: C07D498/06 , C07D519/00
摘要: Novel bactericidal pyrido[1,2,3-d,e,][1,3,4]benzoxadiazine derivatives of the formula (I) ##STR1## in which R.sup.1 is hydrogen or C.sub.1 -C.sub.4 -alkyl optionally substituted by hydroxyl or halogen,R.sup.2 independently of R.sup.1 is hydrogen or methyl,R.sup.3 is hydrogen or C.sub.1 -C.sub.4 -alkyl,R.sup.4 is hydrogen, C.sub.1 -C.sub.4 -alkyl optionally substituted by hydroxyl, methoxy, amino, methylamino or dimethylamino, or (5-methyl-2-oxo-1,3-dioxol-4-yl)-methyl,X.sup.1 is hydrogen or halogen andZ is a radical of the structure ##STR2##
摘要翻译: 式(I)的新型杀菌吡啶并[1,2,3-d,e,] [1,3,4]苯并恶嗪衍生物其中R 1为氢或任选被 羟基或卤素,R 2独立地为R 1为氢或甲基,R 3为氢或C 1 -C 4 - 烷基,R 4为氢,任选被羟基,甲氧基,氨基,甲基氨基或二甲基氨基取代的C 1 -C 4烷基,或(5-甲基 -2-氧代-1,3-二氧杂环戊烯-4-基) - 甲基,X 1是氢或卤素,Z是结构的基团
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29.7-isoindolinyl-naphthyridone derivatives, compositions and anti-bacterial use thereof 失效
标题翻译: 7-异吲哚啉基 - 萘啶酮衍生物,其组合物和抗细菌用途公开(公告)号:US5556979A
公开(公告)日:1996-09-17
申请号:US119369
申请日:1993-09-10
申请人: Thomas Philipps , Stephan Bartel , Andreas Krebs , Uwe Petersen , Thomas Schenke , Klaus-Dieter Bremm , Rainer Endermann , Karl G. Metzger , Burkhard Mielke
发明人: Thomas Philipps , Stephan Bartel , Andreas Krebs , Uwe Petersen , Thomas Schenke , Klaus-Dieter Bremm , Rainer Endermann , Karl G. Metzger , Burkhard Mielke
IPC分类号: A61K31/435 , A61K31/4035 , A61K31/4375 , A61K31/47 , A61K31/4709 , A61K31/535 , A61K31/5383 , A61K31/54 , A61K31/55 , A61P31/04 , C07D209/44 , C07D215/56 , C07D401/04 , C07D405/04 , C07D405/06 , C07D405/14 , C07D471/04 , C07D471/06 , C07D491/18 , C07D491/20 , C07D495/04 , C07D498/06 , C07D498/08 , C07D513/04 , C07D513/06 , C07D513/16 , C07D519/00
CPC分类号: C07D401/04 , C07D209/44 , C07D471/04 , C07D513/06
摘要: The invention relates to novel quinolone derivatives and naphthyridone derivatives which are substituted in the 7-position by a partially hydrogenated isoindolinyl ring, to processes for their preparation and to antibacterial agents and feed additives containing them.
摘要翻译: 本发明涉及通过部分氢化的异吲哚啉基环在7-位被取代的新型喹诺酮衍生物和萘啶酮衍生物,其制备方法以及含有它们的抗菌剂和饲料添加剂。
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30.Derivatives of 1-(2-fluorocyclopropyl)-quinolonecarboxylic acid and 1-(2-fluorocyclopropyl)-naphthridonecarboxylic acid 失效
标题翻译: 1-(2-氟环丙基) - 喹诺酮羧酸和1-(2-氟环丙基) - 萘啶酮羧酸的衍生物公开(公告)号:US5545642A
公开(公告)日:1996-08-13
申请号:US336638
申请日:1994-11-09
申请人: Uwe Petersen , Thomas Schenke , Stefan B ohm , Rolf Grosser , Klaus D. Bremm , Rainer Endermann , Karl G. Metzger
发明人: Uwe Petersen , Thomas Schenke , Stefan B ohm , Rolf Grosser , Klaus D. Bremm , Rainer Endermann , Karl G. Metzger
IPC分类号: C07D487/04 , A61K31/435 , A61K31/47 , A61P31/04 , C07D215/56 , C07D471/04 , C07D519/00 , C07D215/20
CPC分类号: C07D471/04 , C07D215/56
摘要: The invention relates to novel derivatives of 1-(2-fluorocyclopropyl)-quinolonecarboxylic acid and 1-(2-fluorocyclopropyl)-naphthyridonecarboxylic acid which are substituted in the 7 position by a 2,3,4,5,6,7-hexahydro-1H-pyrrolo[3,4-c]pyridin-2-yl or 1,2,3,4,5,6-hexahydropyrrolo[3,4-c]pyrrol-2-yl residue, to their salts, to a process for their preparation and to antibacterial agents containing these derivatives.
摘要翻译: 本发明涉及1-(2-氟环丙基) - 喹诺酮羧酸和1-(2-氟环丙基) - 萘啶酮羧酸的新衍生物,其在7位被2,3,4,5,6,7-六氢 -1H-吡咯并[3,4-c]吡啶-2-基或1,2,3,4,5,6-六氢吡咯并[3,4-c]吡咯-2-基残基, 其制备方法和含有这些衍生物的抗菌剂。
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