公开(公告)号：US20160106731A1

公开(公告)日：2016-04-21

申请号：US14885181

申请日：2015-10-16

Applicant: Vanderbilt University

Inventor： Taekyu Lee ,  Jason P. Burke ,  Edward T. Olejniczak ,  Johannes Belmar ,  Zhiguo Bian ,  Stephen W. Fesik

IPC: A61K31/4745 ,  A61K31/542 ,  A61K45/06 ,  C07D498/06 ,  A61K31/5383 ,  A61K31/554 ,  C07D513/06 ,  C07D471/08

CPC classification number: A61K31/4745 ,  A61K31/5383 ,  A61K31/542 ,  A61K31/554 ,  A61K45/06 ,  C07D471/08 ,  C07D498/06 ,  C07D513/06

Abstract: The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.

Abstract translation: 本发明提供抑制抗凋亡Bcl-2家族成员骨髓细胞白血病-1（Mcl-1）蛋白的活性的化合物。 本发明还提供药物组合物以及使用化合物治疗特征在于Mcl-1蛋白过度表达或失调的疾病和病症（例如癌症）的方法。