公开(公告)号：US20060252733A1

公开(公告)日：2006-11-09

申请号：US11400779

申请日：2006-04-07

申请人： Burkhard Jansen

发明人： Burkhard Jansen

IPC分类号： A61K31/56

CPC分类号： A61K31/56

摘要： The invention relates to method of modulating lipid metabolism comprising contacting a cell with betulin, a betulin derivative, betulinic acid, a betulinic acid derivative, or a related steroid-like compound. In some aspects, the invention relates to the treatment of disorders of lipid metabolism. The invention further relates to methods of identifying compounds that modulate lipid metabolism. The invention also relates to the use of betulin, a betulin derivative, betulinic acid, a betulinic acid derivative, or a related steroid-like compound for preparation of a medicament for the treatment of a disorder of lipid metabolism.

摘要翻译： 本发明涉及调节脂质代谢的方法，包括使细胞与桦木醇，桦木醇衍生物，桦木酸，桦木酸衍生物或相关类固醇样化合物接触。 在一些方面，本发明涉及脂质代谢紊乱的治疗。 本发明还涉及鉴定调节脂质代谢的化合物的方法。 本发明还涉及桦木醇，桦木醇衍生物，桦木酸，桦木酸衍生物或相关类固醇样化合物在制备用于治疗脂质代谢紊乱的药物中的用途。

公开(公告)号：US20060194774A1

公开(公告)日：2006-08-31

申请号：US10545143

申请日：2004-02-11

申请人： Edgar Selzer ,  Burkhard Jansen ,  Reinhard Paschke

发明人： Edgar Selzer ,  Burkhard Jansen ,  Reinhard Paschke

IPC分类号： A61K31/56 ,  C07J53/00

CPC分类号： C07J53/00 ,  C07J63/00

摘要： The present invention relates to novel betulinic acid derivatives with increased activity for the treatment of carcinomas and HIV diseases, a method for preparing such novel betulinic acid derivatives as well as their use as pharmaceuticals.

摘要翻译： 本发明涉及具有增加的用于治疗癌症和HIV疾病的活性的新型桦木酸衍生物，制备这种新型桦木酸衍生物的方法以及它们作为药物的用途。