Gas-filled amino acid block co-polymer microspheres useful as ultrasound
contrast agents
    21.
    发明授权
    Gas-filled amino acid block co-polymer microspheres useful as ultrasound contrast agents 失效
    充气氨基酸嵌段共聚物微球可用作超声造影剂

    公开(公告)号:US5820850A

    公开(公告)日:1998-10-13

    申请号:US486770

    申请日:1995-06-07

    IPC分类号: A61K49/00 A61K49/22 A61K49/04

    CPC分类号: A61K49/223

    摘要: The present invention relates to gas-filled microspheres useful as ultrasound contrast agents. More particularly, the present invention relates to gas-filled microspheres prepared from amphiphilic poly amino acid block co-polymers and a pharmacologically acceptable water-insoluble gas. The hydrophobic block of the co-polymer is formed from amino acids possessing hydrophobic side-chains, for example, leucine, isoleucine, valine, and phenylalanine, and the hydrophilic block of the co-polymer is formed from amino acids possessing hydrophilic side-chains, for example, glutamic acid (and its ionized form, glutamate), aspartic acid (and its ionized form, aspartate), and lysine.

    摘要翻译: 本发明涉及可用作超声造影剂的充气微球。 更具体地说,本发明涉及由两亲性聚氨基酸嵌段共聚物制备的充气微球和药理学上可接受的不溶于水的气体。 共聚物的疏水嵌段由具有疏水侧链的氨基酸形成,例如亮氨酸,异亮氨酸,缬氨酸和苯丙氨酸,共聚物的亲水嵌段由具有亲水侧链的氨基酸形成 例如谷氨酸(及其电离形式,谷氨酸),天冬氨酸(及其电离形式,天冬氨酸)和赖氨酸。

    Apparatus for sorting and transporting sheets
    23.
    发明授权
    Apparatus for sorting and transporting sheets 失效
    用于分拣和运输床单的设备

    公开(公告)号:US4994847A

    公开(公告)日:1991-02-19

    申请号:US420314

    申请日:1989-10-12

    摘要: An apparatus for sorting and transferring sheets comprises storing means for storing a stack of sheets, first transferring means for transferring a sheet located at an end of the stack of the sheets from the storing means in a first direction, and second transferring means for transferring the next sheet located at the end of the stack of the sheets from the storing means in a second direction. The first and second directions are different from each other. The apparatus for sorting and transferring the sheets is applied; for example, to an automatic original transferring apparatus and a temporary storing tray of a copying machine.

    摘要翻译: 一种用于分纸和转印纸的设备包括:用于存储纸张堆的存储装置;第一转印装置,用于沿着第一方向从存储装置转印位于纸张堆的一端的纸页;以及第二转印装置, 在第二方向上从存储装置位于纸张堆的末端的下一张纸。 第一和第二方向彼此不同。 应用用于分拣和转印纸张的装置; 例如涉及复印机的自动原稿传送装置和临时存放托盘。

    Method for processing glyceride fats and oils
    24.
    发明授权
    Method for processing glyceride fats and oils 失效
    甘油酯脂肪和油的加工方法

    公开(公告)号:US4985358A

    公开(公告)日:1991-01-15

    申请号:US167240

    申请日:1988-03-11

    摘要: A method for processing glyceride fats and oils which comprises the steps of subjecting a mixture of a glyceride fat or oil and a monohydric alcohol fatty acid ester to an enzymatic ester interchange reaction; distilling the reaction mixture of the ester interchange reaction to separate a distillate from a processed glyceride fat or oil to recover the latter; subjecting the distillate to an esterification reaction to lower its acid value; and recycling the distillate for use as a starting material for the ester interchange reaction.

    摘要翻译: 一种加工甘油酯脂肪和油的方法,其包括将甘油酯脂肪或油和一元醇脂肪酸酯的混合物进行酶促酯交换反应的步骤; 蒸馏酯交换反应的反应混合物,以将馏出物与加工的甘油酯脂肪或油分离以回收后者; 使馏出物进行酯化反应以降低其酸值; 并将该馏出物再循环用作酯交换反应的起始原料。

    Optically active cephalosporin analogs
    25.
    发明授权
    Optically active cephalosporin analogs 失效
    光学活性头孢菌素类似物

    公开(公告)号:US4663450A

    公开(公告)日:1987-05-05

    申请号:US788660

    申请日:1985-10-17

    摘要: Optically active cephalosporin analogs of the formula ##STR1## wherein R.sub.2 represents a hydrogen or a group represented by the formula ##STR2## wherein R.sub.3 is a straight or branched lower alkyl group having 1 to 6 carbon atoms, a straight or branched lower alkoxy group having 1 to 6 carbon atoms or a phenyl group and R.sub.4 is a hydrogen or a straight or branched lower alkyl group having 1 to 6 carbon atoms; and A.sub.2 represents a straight or branched lower alkyl group having 1 to 6 carbon atoms or a straight or branched lower alkyl group having 1 to 6 carbon atoms which is substituted with one or two carboxyl groups, are useful as antibacterial agents.

    摘要翻译: 其中R2代表氢或由下式表示的基团的光学活性头孢菌素类似物:其中R 3是具有1-6个碳原子的直链或支链低级烷基,具有直链或支链的低级烷氧基, 1〜6个碳原子或苯基,R4为氢或碳原子数为1〜6的直链或支链的低级烷基; A2表示碳原子数1〜6的直链或支链的低级烷基或碳原子数1〜6的直链或支链的低级烷基,被一个或两个羧基取代,可用作抗菌剂。

    Frequency division circuit
    27.
    发明授权
    Frequency division circuit 失效
    分频电路

    公开(公告)号:US4119867A

    公开(公告)日:1978-10-10

    申请号:US708188

    申请日:1976-07-23

    摘要: An odd number of inverting memory blocks are connected in series in a closed ring circuit. Each inverting elememt comprises a P channel field effect transistor and an N channel field effect transistor which are connected in parallel opposition. Control signals of the same phase are applied to the gate electrodes of the P and N channel field effect transistors. An inverter circuit comprising a pair of field effect transistors having gate electrodes is connected to one of two parallel connected, conductive electrodes of a temporary memory switching circuit. Control gate electrodes of the inverting memory block are controlled by control signals having the same phase and at a frequency to be divided for producing a frequency divided output from the output of one of the inverting memory blocks.

    摘要翻译: 奇数个反相存储器块串联连接在闭环电路中。 每个反相元件包括平行相对连接的P沟道场效应晶体管和N沟道场效应晶体管。 将相同相位的控制信号施加到P沟道场效应晶体管和N沟道场效应晶体管的栅电极。 包括具有栅电极的一对场效应晶体管的逆变器电路连接到临时存储器开关电路的两个并联连接的导电电极中的一个。 反相存储器块的控制栅电极由具有相同相位和待分频的控制信号控制,以产生从反转存储器块之一的输出的分频输出。

    Processed cheese-like product containing soy cheese
    28.
    发明授权
    Processed cheese-like product containing soy cheese 失效
    加工干酪样产品含有大豆奶酪

    公开(公告)号:US4080477A

    公开(公告)日:1978-03-21

    申请号:US626299

    申请日:1975-10-28

    摘要: A processed cheese-like product containing soy cheese as a part of the major ingredient is made by adding both a casein-containing substance derived from animal milk and a cheese emulsifying melting salt to natural soy cheese and agitating this mixture under relatively high shearing conditions, while heating to an elevated temperature of less than about 85.degree. C, for a period sufficient to form the mixture into a softened, flowable consistency. After pasteurization, the melted or softened mixture is introduced into a suitable container and cooled to produce a processed cheese-like product having superior flavor and texture characteristics.

    摘要翻译: 含有大豆乳酪作为主要成分的一部分的加工干酪样产品通过将来自动物乳的酪蛋白含量物质和乳酪乳化熔盐加入到天然大豆乳酪中并在相对高的剪切条件下搅拌该混合物来制备, 同时加热到低于约85℃的升高的温度,持续足以将混合物形成软化的可流动的稠度的时间。 在巴氏消毒之后,将熔融或软化的混合物引入合适的容器中并冷却以产生具有优异风味和质地特征的加工的乳酪样产品。

    Temperature compensated electronic timepiece
    29.
    发明授权
    Temperature compensated electronic timepiece 失效
    温度补偿电子表

    公开(公告)号:US3938316A

    公开(公告)日:1976-02-17

    申请号:US440240

    申请日:1974-02-06

    IPC分类号: G04F5/06 H03L1/02 G04C3/00

    CPC分类号: G04F5/06 H03L1/022 H03L1/026

    摘要: A temperature compensated electronic timepiece comprises a time reference signal generator for generating a time reference signal and a temperature compensating device for compensating a change of the oscillating frequency of the time reference signal generator caused by any external temperature change. The temperature compensating device comprises a temperature detector having an element composed of two semiconductors of different respective conductivities (such as a transistor composed of P and N type semiconductors) which are joined to form a junction, or an element composed of a conductor and a semiconductor joined to form a junction. The voltage-current characteristics of the junction are changed when the external temperature exceeds a given temperature to deliver a digital signal whose state is reversed from an initial condition. The output signal from the temperature detector compensates any temperature change of the oscillating frequency of the time reference signal generator.

    摘要翻译: 温度补偿电子钟表包括用于产生时间参考信号的时间参考信号发生器和用于补偿由任何外部温度变化引起的时间参考信号发生器的振荡频率变化的温度补偿装置。 温度补偿装置包括温度检测器,该温度检测器具有由两个不同相应电导率的半导体(例如由P型和N型半导体组成的晶体管)组成的元件,该半导体被连接以形成结,或由导体和半导体构成的元件 加入形成交界处。 当外部温度超过给定温度时,结点的电压 - 电流特性发生变化,从而将其状态从初始状态反转。 来自温度检测器的输出信号补偿时间参考信号发生器的振荡频率的任何温度变化。