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    Human monoclonal antibody against TGF-β type II receptor and medicinal use thereof
    21.
    发明授权
    Human monoclonal antibody against TGF-β type II receptor and medicinal use thereof 失效
    针对TGF-β2型受体的人单克隆抗体及其医药用途

    公开(公告)号：US07579186B1

    公开(公告)日：2009-08-25

    申请号：US10130034

    申请日：2000-11-17

    申请人： Shinji Sakamoto ,  Masafumi Kamada

    发明人： Shinji Sakamoto ,  Masafumi Kamada

    IPC分类号： C12N5/06 ,  C07K16/28

    CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/74

    摘要： Various human monoclonal antibodies that bind to human TGF-β type II receptor to inhibit the signal transduction of human TGF-β signal into cells are produced by immunizing human antibody-producing transgenic mice generated by genetic engineering techniques with the soluble human TGF-β type II receptor. Further, these human monoclonal antibodies were demonstrated to be effective for preventing and treating various diseases induced by human TGF-β in various organs (for example, tissue fibrosis).

    摘要翻译： 通过用可溶性人TGF-β型的遗传工程技术免疫产生的产生抗体的转基因小鼠，产生与人TGF-β2型受体结合以抑制人TGF-β信号向细胞中信号转导的各种人单克隆抗体 II受体。 此外，这些人单克隆抗体被证明对于预防和治疗各种器官（例如组织纤维化）中由人TGF-β诱导的各种疾病是有效的。