公开(公告)号：US20120128713A1

公开(公告)日：2012-05-24

申请号：US13256565

申请日：2010-03-16

申请人： Konstantin V. Pugachev ,  Alexander A. Rumyantsev ,  Maryann Giel-Moloney ,  Mark Parrington ,  Linong Zhang

发明人： Konstantin V. Pugachev ,  Alexander A. Rumyantsev ,  Maryann Giel-Moloney ,  Mark Parrington ,  Linong Zhang

IPC分类号： C12N7/00 ,  C12N15/45 ,  A61K39/295

CPC分类号： A61K39/155 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/70 ,  C12N7/00 ,  C12N15/86 ,  C12N2760/18534 ,  C12N2760/20134 ,  C12N2770/24143 ,  C12N2770/24162

摘要： Replication-defective vaccine vectors against respiratory syncytial virus (RSV) are disclosed. Corresponding compositions and methods employing the vaccine vectors are also disclosed.

摘要翻译： 公开了针对呼吸道合胞病毒（RSV）的复制缺陷型疫苗载体。 还公开了使用疫苗载体的相应组合物和方法。

公开(公告)号：US07875439B2

公开(公告)日：2011-01-25

申请号：US12001605

申请日：2007-12-12

申请人： Lynn Doucette-Stamm ,  David Bush ,  Qiandong Zeng ,  Timothy Opperman ,  Chad Eric Houseweart

发明人： Lynn Doucette-Stamm ,  David Bush ,  Qiandong Zeng ,  Timothy Opperman ,  Chad Eric Houseweart

IPC分类号： C12N15/09 ,  C07H21/04 ,  C12P21/04 ,  A61K39/09

CPC分类号： C07K14/3156 ,  A61K31/7052 ,  A61K39/00 ,  A61K39/092 ,  A61K2039/53 ,  C07H21/02 ,  C07H21/04 ,  C07K14/315 ,  Y02A50/472

摘要： The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.

公开(公告)号：US07867501B2

公开(公告)日：2011-01-11

申请号：US11524943

申请日：2006-09-21

申请人： Lynn Doucette-Stamm ,  David Bush ,  Oiandong Zeng ,  Timothy Opperman ,  Chad Eric Houseweart

发明人： Lynn Doucette-Stamm ,  David Bush ,  Oiandong Zeng ,  Timothy Opperman ,  Chad Eric Houseweart

IPC分类号： A61K39/09 ,  C07K14/195 ,  C07H21/04 ,  C12P21/04

CPC分类号： C07K14/3156 ,  A61K31/7052 ,  A61K39/00 ,  A61K39/092 ,  A61K2039/53 ,  C07H21/02 ,  C07H21/04 ,  C07K14/315 ,  Y02A50/472

摘要： The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.

公开(公告)号：US07582449B2

公开(公告)日：2009-09-01

申请号：US11801963

申请日：2007-05-11

申请人： Lynn Doucette-Stamm ,  David Bush ,  Qiandong Zeng ,  Timothy Opperman ,  Chad Eric Houseweart

发明人： Lynn Doucette-Stamm ,  David Bush ,  Qiandong Zeng ,  Timothy Opperman ,  Chad Eric Houseweart

IPC分类号： C12N15/56 ,  C12N15/70 ,  C12N15/74 ,  C12N15/79 ,  C12N15/81 ,  C12N15/85 ,  C12N15/866 ,  A61K39/09

CPC分类号： C07K14/3156 ,  A61K31/7052 ,  A61K39/00 ,  A61K39/092 ,  A61K2039/53 ,  C07H21/02 ,  C07H21/04 ,  C07K14/315 ,  Y02A50/472

摘要： The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.

公开(公告)号：US20090148890A1

公开(公告)日：2009-06-11

申请号：US11803132

申请日：2007-05-11

申请人： Lynn Doucette-Stamm ,  David Bush ,  Qiandong Zeng ,  Timothy Opperman ,  Chad Eric Houseweart

发明人： Lynn Doucette-Stamm ,  David Bush ,  Qiandong Zeng ,  Timothy Opperman ,  Chad Eric Houseweart

IPC分类号： C12P21/00

CPC分类号： C07K14/3156 ,  A61K31/7052 ,  A61K39/00 ,  A61K39/092 ,  A61K2039/53 ,  C07H21/02 ,  C07H21/04 ,  C07K14/315 ,  Y02A50/472

摘要： The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.

摘要翻译： 本发明提供了分离的多肽和源自肺炎链球菌的核酸序列，其可用于诊断和治疗病理状况; 针对多肽的抗体; 以及用于制备多肽的方法。 本发明还提供了用于检测，预防和治疗由细菌感染引起的病理状况的方法。

公开(公告)号：US20080124794A1

公开(公告)日：2008-05-29

申请号：US12001437

申请日：2007-12-11

申请人： Lynn Doucette-Stamm ,  David Bush ,  Qiandong Zeng ,  Timothy Opperman ,  Chad Eric Houseweart

发明人： Lynn Doucette-Stamm ,  David Bush ,  Qiandong Zeng ,  Timothy Opperman ,  Chad Eric Houseweart

IPC分类号： C07H21/04 ,  C12N15/00 ,  C12N5/00

CPC分类号： C07K14/3156 ,  A61K31/7052 ,  A61K39/00 ,  A61K39/092 ,  A61K2039/53 ,  C07H21/02 ,  C07H21/04 ,  C07K14/315 ,  Y02A50/472

摘要： The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.

公开(公告)号：US20210171653A1

公开(公告)日：2021-06-10

申请号：US17112862

申请日：2020-12-04

申请人： Sanofi-Aventis U.S. LLC ,  Sanofi

发明人： Marie-Laure RISSE ,  Gaelle ASSET

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K31/573 ,  A61K31/5355

摘要： The present disclosure provides methods for treating multiple myeloma (such as refractory multiple myeloma or relapsed and refractory multiple myeloma) in an individual who received one to three prior therapies (or prior lines of therapy) for multiple myeloma. The methods comprise administering to the individual an anti-CD38 antibody, carfilzomib, and dexamethasone.

公开(公告)号：US20080131964A1

公开(公告)日：2008-06-05

申请号：US12001752

申请日：2007-12-12

申请人： Lynn Doucette-Stamm ,  David Bush ,  Qiandong Zeng ,  Timothy Opperman ,  Chad Eric Houseweart

发明人： Lynn Doucette-Stamm ,  David Bush ,  Qiandong Zeng ,  Timothy Opperman ,  Chad Eric Houseweart

IPC分类号： C12N5/06 ,  C12N15/11 ,  C12N15/00

CPC分类号： C07K14/3156 ,  A61K31/7052 ,  A61K39/00 ,  A61K39/092 ,  A61K2039/53 ,  C07H21/02 ,  C07H21/04 ,  C07K14/315 ,  Y02A50/472

摘要： The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.

公开(公告)号：US20230131037A1

公开(公告)日：2023-04-27

申请号：US18085193

申请日：2022-12-20

申请人： Sanofi-Aventis Deutschland GMBH

发明人： Michael Schabbach ,  Beate Franke ,  Giuliano Pradel ,  Ilario Melzi ,  Stefan Verlaak ,  Andrew Nelson

IPC分类号： A61M5/142 ,  A61M5/20 ,  A61M5/148

摘要： The present disclosure relates to a medicament delivery device. The medicament delivery device comprises a housing, a needle and a reservoir. The needle is configured to project from a distal end of the housing. The reservoir is disposed in the housing and has a flexible wall. The medicament delivery device further comprises a dispensing member and a biasing member. The dispensing member is disposed in the housing and the biasing member is configured to bias the dispensing member to move in an arcuate path relative to the housing such that the dispensing member moves across the flexible wall of the reservoir to dispense medicament from the reservoir when the reservoir contains medicament.

公开(公告)号：US20230126164A1

公开(公告)日：2023-04-27

申请号：US18082253

申请日：2022-12-15

申请人： Sanofi-Aventis Deutschland GMBH

发明人： Carsten Mosebach ,  Thomas Kemp

IPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/32

摘要： An autoinjector includes a case adapted to hold a medicament container having a needle, a needle shroud telescopically coupled to the case, and a plunger rotationally and slidably disposed in the case. The needle shroud is movable between a first extended position relative to the case in which the needle is covered and a retracted position relative to the case in which the needle is exposed. The plunger is rotatable relative to the case between a first rotational position in which the plunger is engaged to the case and a second rotational position in which the plunger disengages the case. The needle shroud is operably coupled to the plunger. When the needle shroud translates from the first extended position to the retracted position, the plunger rotates from the first rotational position to the second rotational position.