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1734 条记录 (耗时 0.035 秒)

    TRANSFECTION METHOD
    21.
    发明申请
    TRANSFECTION METHOD 有权

    公开(公告)号：US20220251576A1

    公开(公告)日：2022-08-11

    申请号：US17622580

    申请日：2020-06-25

    申请人： Takeda Pharmaceutical Company Limited

    发明人： Naoyuki MURATA ,  Sayan CHUANOI ,  Shigeo YANAI

    IPC分类号： C12N15/64 ,  C07K14/725 ,  A61P37/00 ,  A61K9/00 ,  A61K9/51 ,  A61K9/08 ,  A61K47/26

    摘要： A novel means for safely and efficiently introducing a target substance such as nucleic acid, protein, or the like into immune cells such as T cell and the like is provided by the present invention. Thus, a system for delivering a target substance into an immune cell, including ultrafine bubble water or ultrafine bubble aqueous solution containing ultrafine bubbles with an average diameter of not more than 200 nm and not containing phospholipid, and an ultrasound generator in combination; a method for increasing the delivery of a nucleic acid or a protein into an immune cell by using the ultrafine bubble water, etc. and ultrasound; and the like are provided.

    COMPOSITIONS OF THIENOPYRIMIDINE DERIVATIVES
    24.
    发明申请
    COMPOSITIONS OF THIENOPYRIMIDINE DERIVATIVES 有权

    公开(公告)号：US20220204525A1

    公开(公告)日：2022-06-30

    申请号：US17694635

    申请日：2022-03-14

    申请人： Takeda Pharmaceutical Company Limited

    发明人： Koichiro FUKUOKA ,  Kazuhiro MIWA ,  Tsuyoshi SASAKI ,  Fumiya KOMURA

    IPC分类号： C07D495/04 ,  C07D333/38 ,  C07D409/12

    摘要： The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrirnidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or salt thereof, 1,1′-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like.

    TREATMENT OF CNS CONDITIONS
    26.
    发明申请
    TREATMENT OF CNS CONDITIONS 有权

    公开(公告)号：US20220168294A1

    公开(公告)日：2022-06-02

    申请号：US17673072

    申请日：2022-02-16

    申请人： Takeda Pharmaceutical Company Limited

    发明人： Toshiya Nishi ,  Shinichi KONDO

    IPC分类号： A61K31/4545 ,  A61P25/08

    摘要： Aspects of the present invention relate to a method of treating an epileptic encephalopathy in a mammal in need thereof, comprising administering a composition comprising an effective amount of (4-benzyl-4-hydroxypiperidin-1-yl) (2,4′-bipyridin-3-yl)methanone or a pharmaceutically acceptable salt thereof to the mammal.

    Anti-plasma kallikrein antibodies
    28.
    发明授权
    Anti-plasma kallikrein antibodies 有权

    公开(公告)号：US11299553B2

    公开(公告)日：2022-04-12

    申请号：US16199453

    申请日：2018-11-26

    申请人： Takeda Pharmaceutical Company Limited

    发明人： Andrew Nixon ,  Jon A. Kenniston ,  Stephen R. Comeau

    IPC分类号： C07K16/40 ,  C12N15/52

    摘要： Disclosed herein are antibodies capable of binding to plasma kallikrein and inhibit its activity. Such antibodies interact with one or more critical residues in the catalytic domain of the plasma kallikrein. The antibodies may also contain specific heavy chain complementarity determining region 3 (CDRs) motifs and optionally specific residues at certain positions within both the heavy chain variable region and the light chain variable region.

    METHOD FOR DETECTING CELLS
    30.
    发明申请
    METHOD FOR DETECTING CELLS 有权

    公开(公告)号：US20220099670A1

    公开(公告)日：2022-03-31

    申请号：US17427222

    申请日：2021-01-31

    申请人： Kyoto University ,  TAKEDA PHARMACEUTICAL COMPANY LIMITED

    发明人： Shin KANEKO ,  Shoichi IRIGUCHI ,  Keiko SEKIYA ,  Yoshiaki KASSAI

    IPC分类号： G01N33/567 ,  C12N5/00 ,  C12N5/0784 ,  G01N33/50

    摘要： Disclosed is a method for detecting regulatory dendritic cells, the method comprising step a: detecting the presence or absence of one or more types of molecules on a cell surface in a cell population that comprises regulatory dendritic cells; and step b: identifying regulatory dendritic cells on the basis of the presence or absence of the one or more types of molecules. Also disclosed is a method for producing a cell population enriched for regulatory dendritic cells, the method comprising step 1: detecting the presence or absence of one or more types of molecules on a cell surface in a cell population that comprises regulatory dendritic cells; and step 2: obtaining a cell population enriched for regulatory dendritic cells on the basis of the presence or absence of the one or more types of molecules. Further disclosed is a cell population enriched for regulatory dendritic cells obtained by the method.