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公开(公告)号：US06374876B2
公开(公告)日：2002-04-23
申请号：US09809479
申请日：2001-03-15
申请人： Gail Bynum
发明人： Gail Bynum
IPC分类号： B65B104
CPC分类号： A61M5/14228 , A61M5/1409 , A61M2209/045 , Y10S128/12
摘要： A cassette is described including a housing, an inner reservoir located within the housing, a valve coupled to the inner reservoir and coupled to the housing, and a delivery conduit coupled to the inner reservoir and emerging from the delivery opening of the cassette. The cassette also includes a dispensing apparatus that defines a passage and has a first activating device that opens the valve of the cassette. The dispensing apparatus also has a second activating member capable of establishing fluid communication with a medicant container. A method of mixing a powdered drug and a liquid includes establishing fluid communication between the reservoir and the medicant container, dispensing at least a portion of the liquid into the medicant container, and transferring the mixed drug into the reservoir. A method of filling a cassette includes the steps of introducing the drug into the cassette, closing a first access port, evacuating the inner reservoir through a second access port, and introducing the drug to fill the cassette through the first access port.
摘要翻译： 描述了一种盒，其包括壳体，位于壳体内的内部容器，联接到内部容器并联接到壳体的阀，以及连接到内部容器并从盒的输送开口出来的输送导管。 盒还包括限定通道的分配装置，并具有打开盒的阀的第一启动装置。 分配装置还具有能够与药剂容器建立流体连通的第二激活构件。 混合粉末状药物和液体的方法包括建立储存器与药剂容器之间的流体连通，将至少一部分液体分配到药剂容器中，并将混合药物转移到储存器中。 一种填充盒的方法包括以下步骤：将药物引入盒中，关闭第一进入端口，通过第二进入口排出内储存器，并引入药物以通过第一进入口填充盒。
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公开(公告)号：US06358239B1
公开(公告)日：2002-03-19
申请号：US08987601
申请日：1997-12-09
IPC分类号： A61K922
CPC分类号： A61M5/148 , A61M2005/14506 , A61M2209/045 , Y10S128/12 , Y10S128/13
摘要： Disclosed is an infusion pump for expelling a fluid from a collapsible fluid reservoir to a patient. The pump includes a housing having a chamber therein for receiving the fluid reservoir. A first wall is provided on the housing for contacting the fluid reservoir, and a second wall is movable from a first position distanced from the first wall to form the chamber therebetween, and a second position relatively closer to the first wall. Advancing the movable wall from the first position to the second position expels fluid from the collapsible reservoir at a substantially constant rate by applying increasing force on the fluid reservoir through the dispensation cycle. Preferably, the first and second walls are provided with non-planar complementary surface configurations for contacting the collapsible reservoir. Retraction mechanisms for retracting the movable wall from the second position to the first position, and user readable indicium of the status of the dispensation cycle are also disclosed.
摘要翻译： 公开了一种用于将流体从可折叠流体储存器排出到患者的输液泵。 泵包括壳体，其中具有用于接收流体储存器的室。 第一壁设置在壳体上用于接触流体储存器，第二壁可从远离第一壁的第一位置移动以在其间形成室，以及相对更靠近第一壁的第二位置。 将活动壁从第一位置推进到第二位置通过在分配循环中对流体储存器施加增加的力而以基本上恒定的速率从可收缩储存器排出流体。 优选地，第一和第二壁设置有用于接触可折叠储存器的非平面互补表面构造。 还公开了用于将活动壁从第二位置缩回到第一位置的退回机构以及分配周期状态的用户可读标记。
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公开(公告)号：US06280416B1
公开(公告)日：2001-08-28
申请号：US09253382
申请日：1999-02-19
IPC分类号： A61M3700
CPC分类号： A61M5/14276 , A61M5/141 , A61M5/1483 , A61M5/155 , Y10S128/12
摘要： A medication infusion pump includes a housing, a medication chamber defined within the housing, a medication delivery device in fluid communication with the medication chamber, a propellant chamber defined within the housing and adapted to apply a predetermined positive pressure to a medication in the medication chamber, and a non-ozone depleting, non-toxic propellant within the propellant chamber. The propellant preferably has a vapor pressure between about 11 psig and about 50 psig at 37° C.
摘要翻译： 药物输注泵包括壳体，限定在所述壳体内的药物室，与所述药物室流体连通的药物输送装置，限定在所述壳体内的推进剂室，并适于对所述药物室中的药物施加预定的正压力 ，以及推进剂室内的非消耗臭氧，无毒的推进剂。 推进剂优选在37℃下的蒸汽压在约11psig至约50psig之间。
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公开(公告)号：US06277095B1
公开(公告)日：2001-08-21
申请号：US09312590
申请日：1999-05-14
IPC分类号： A61M3700
CPC分类号： A61M5/158 , A61M5/14248 , A61M5/152 , A61M2005/1581 , A61M2205/197 , A61M2209/045 , Y10S128/12
摘要： A fluid delivery device for infusing medicinal fluids at a precisely controlled rate which includes adapter sleeve means for insuring that only a proper medicament can be used to fill the fluid reservoir of the apparatus. More particularly, the apparatus includes a unique polarity adapter that will mate only with a particular delivery device and positively prevent filling the reservoir of the device with a medicament that is incompatible with the delivery profile of the device. In one form of the invention, the polarity adapter includes a novel double-ended cannula that is carried within the polarity adapter and controls filling of the fluid reservoir.
摘要翻译： 一种用于以精确控制的速率输注药液的流体递送装置，其包括用于确保只有适当的药物可以用于填充装置的流体储存器的适配器套筒装置。 更具体地说，该装置包括独特的极性适配器，该适配器仅与特定的输送装置配合，并且通过与装置的输送轮廓不相容的药剂来确定地防止装置的储存器的填充。 在本发明的一种形式中，极性适配器包括一个新颖的双端套管，其被携带在极性适配器内并控制流体储存器的填充。
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公开(公告)号：US06200293B1
公开(公告)日：2001-03-13
申请号：US09489426
申请日：2000-01-21
IPC分类号： A61M3700
CPC分类号： A61M5/14586 , A61M5/14248 , A61M2205/36 , A61M2205/3613 , Y10S128/12
摘要： A fluid delivery apparatus for infusing medicinal fluids into a patient which is of a compact, low profile, laminate construction. The apparatus embodies a novel thermal expanding polymer material which uniquely functions as an internal energy source for expelling the medicinal fluids from the device. The apparatus can be used for subdermal, intradermal and intramuscular infusion of fluids and in one form of the invention, includes a novel delivery cannula having a body portion disposed within a circuitous channel formed within the base superstructure of the apparatus and a pierceable portion which extends outwardly from the base of the apparatus. By constructing the cannula in a circuitous configuration and dynamically connecting it to the base assembly, movement of the cannula relative to the base assembly is permitted thereby minimizing needle related tissue necrosis. The heat-expandable mass which is heated by the patient's body temperature in a manner to controllably expel fluid from the device uniquely functions to provide a conformable ullage within the reservoir of the device which will effectively avoid extended flow delivery rate trail-off at the end of the fluid delivery period. Further, the heat expandable mass can be specifically tailored to provide precise, predictable protocol delivery of the medicinal agent stored within the reservoir of the device.
摘要翻译： 一种用于将药液注入患者体内的流体输送装置，该流体输送装置具有紧凑的薄型叠层结构。 该设备体现了一种新颖的热膨胀聚合物材料，其独特地用作用于从设备中排出药液的内部能源。 该装置可用于流体的皮下，皮内和肌肉内输注，并且在本发明的一种形式中，包括新颖的输送套管，其具有设置在形成于装置的基础上部结构内的迂回通道内的主体部分和延伸的可刺穿部分 从设备的底部向外。 通过以迂回构造构造插管并将其动态地连接到基座组件，允许插管相对于基座组件的移动，从而最小化针相关的组织坏死。 由患者体温加热的可膨胀物质以可控地排出装置中的流体的方式独特地起作用，以在装置的储存器内提供一致的缺口，这将有效地避免在末端延长的流量传送速率的下降 的流体输送期。 此外，热可膨胀物质可以被特别地定制以提供存储在装置的储存器中的药剂的精确的，可预测的方案递送。
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公开(公告)号：US06174300B1
公开(公告)日：2001-01-16
申请号：US09387447
申请日：1999-09-01
IPC分类号： A61M3700
CPC分类号： A61M5/14248 , A61M5/14586 , A61M31/002 , A61M2205/36 , A61M2205/3613 , Y10S128/12
摘要： A fluid delivery apparatus for infusing medicinal fluids into a patient which is of a compact, low profile, laminate construction. The apparatus embodies a novel thermal expanding polymer material which uniquely functions as an internal energy source for expelling the medicinal fluids from the device. The apparatus can be used for subdermal, intradermal and intramuscular infusion of fluids and in one form of the invention, includes a novel delivery cannula having a body portion disposed within a circuitous channel formed within the base superstructure of the apparatus and a pierceable portion which extends outwardly from the base of the apparatus. By constructing the cannula in a circuitous configuration and dynamically connecting it to the base assembly, movement of the cannula relative to the base assembly is permitted thereby minimizing needle related tissue necrosis. The heat-expandable mass which is heated by the patient's body temperature in a manner to controllably expel fluid from the device uniquely functions to provide a conformable ullage within the reservoir of the device which will effectively avoid extended flow delivery rate trail-off at the end of the fluid delivery period. Further, the heat expandable mass can be specifically tailored to provide precise, predictable protocol delivery of the medicinal agent stored within the reservoir of the device.
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公开(公告)号：US6099502A
公开(公告)日：2000-08-08
申请号：US957228
申请日：1997-10-24
申请人： Doug Duchon , Thomas Paulson , Vince Copa , Robert F. Wilson , Jiyan Liu
发明人： Doug Duchon , Thomas Paulson , Vince Copa , Robert F. Wilson , Jiyan Liu
IPC分类号： A61M5/31 , A61M5/00 , A61M5/14 , A61M5/142 , A61M5/145 , A61M5/172 , A61M5/178 , A61M5/50 , A61M31/00 , A61M37/00 , A61M1/00
CPC分类号： A61M5/14216 , A61B6/504 , A61M31/005 , A61M5/14546 , A61M5/172 , A61M5/5066 , A61B6/548 , A61M2005/1403 , A61M2205/3561 , A61M2205/3653 , A61M2209/01 , A61M2230/04 , A61M5/007 , A61M5/1723 , A61M5/445 , Y10S128/01 , Y10S128/12
摘要： A dual port syringe has an upper port for connection to a fluid reservoir and a lower port for delivery of the medical fluid under pressure to a patient. A first valve is connected between the fluid reservoir and the upper port, and second valve is connected between the lower port and the patient. During a fill operation, a piston is moved within the syringe to drawn fluid from the reservoir into the syringe through the upper port. During injection operation, the piston moves in an opposite direction to force fluid out of the syringe through the lower port.
摘要翻译： 双端口注射器具有用于连接到流体储存器的上端口和用于将压力下的医用流体输送给患者的下端口。 第一阀连接在流体储存器和上端口之间，第二阀连接在下端口和患者之间。 在填充操作期间，活塞在注射器内移动以通过上端口将流体从储存器抽入注射器。 在注射操作期间，活塞沿相反方向移动，以迫使流体通过下端口流出注射器。
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公开(公告)号：US6093180A
公开(公告)日：2000-07-25
申请号：US912379
申请日：1997-08-18
申请人： Dennis D. Elsberry
发明人： Dennis D. Elsberry
CPC分类号： A61M25/001 , A61M25/0068 , A61M2025/0057 , A61M2025/0073 , A61M25/0009 , A61M25/0069 , Y10S128/12
摘要： An intraparenchymal infusion catheter system for delivering drugs or other agents to selected sites in an organism, such as a human, includes a pump that may be implanted or disposed outside the organism. A catheter is coupled to the pump. The catheter comprises a flexible biocompatible tubular portion terminating in a free distal end. The distal end of the catheter bears a rounded tip, a portion of which is slidably disposed within the lumen of the tubular portion. The tip is porous for discharging an agent or drug to a selected site. The tip has a microporosity of less than or equal to 0.22 microns. The tubular portion is composed from a material that will expand from its nominal size when exposed to a stimulus such as heat or a solvent and return to its nominal size when the stimulus is withdrawn. By expanding the tubular portion, a physician can select the amount of the tip that is exposed to the organism, thereby customizing the catheter to the structural size of the selected site within the body.
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公开(公告)号：US5961492A
公开(公告)日：1999-10-05
申请号：US919147
申请日：1997-08-27
CPC分类号： A61M5/14248 , A61M31/002 , A61M5/14586 , A61M2205/36 , A61M2205/3613 , Y10S128/12
摘要： A fluid delivery apparatus for infusing medicinal fluids into a patient which is of a compact, low profile, laminate construction. The apparatus embodies a novel thermal expanding polymer material which uniquely functions as an internal energy source for expelling the medicinal fluids from the device. The apparatus can be used for subdermal, intradermal and intramuscular infusion of fluids and in one form of the invention, includes a novel delivery cannula having a body portion disposed within a circuitous channel formed within the base superstructure of the apparatus and a pierceable portion which extends outwardly from the base of the apparatus. By constructing the cannula in a circuitous configuration and dynamically connecting it to the base assembly, movement of the cannula relative to the base assembly is permitted thereby minimizing needle related tissue necrosis. The heat-expandable mass which is heated by the patient's body temperature in a manner to controllably expel fluid from the device uniquely functions to provide a conformable ullage within the reservoir of the device which will effectively avoid extended flow delivery rate trail-off at the end of the fluid delivery period. Further, the heat expandable mass can be specifically tailored to provide precise, predictable protocol delivery of the medicinal agent stored within the reservoir of the device.
摘要翻译： 一种用于将药液注入患者体内的流体输送装置，该流体输送装置具有紧凑的薄型叠层结构。 该设备体现了一种新颖的热膨胀聚合物材料，其独特地用作用于从设备中排出药液的内部能源。 该装置可用于流体的皮下，皮内和肌肉内输注，并且在本发明的一种形式中，包括新颖的输送套管，其具有设置在形成于装置的基础上部结构内的迂回通道内的主体部分和延伸的可刺穿部分 从设备的底部向外。 通过以迂回构造构造插管并将其动态地连接到基座组件，允许插管相对于基座组件的移动，从而最小化针相关的组织坏死。 由患者体温加热的可膨胀物质以可控地排出装置中的流体的方式独特地起作用，以在装置的储存器内提供一致的缺口，这将有效地避免在末端延长的流量传送速率的下降 的流体输送期。 此外，热可膨胀物质可以被特别地定制以提供存储在装置的储存器中的药剂的精确的，可预测的方案递送。
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公开(公告)号：US5954696A
公开(公告)日：1999-09-21
申请号：US990362
申请日：1997-12-15
申请人： Timothy C. Ryan
发明人： Timothy C. Ryan
CPC分类号： A61M5/16831 , A61M5/1483 , A61M2205/8225 , Y10S128/12
摘要： A portable, ambulatory infusion pump for use with standard pre-filled infusion medicament containers is powered by a miniature compressed gas cylinder coupled to a mechanical pressure regulator which supplies regulated gas at a substantially constant pressure to an inflatable bladder. The bladder is positioned between a substantially rigid pressure surface and a moveable pressure transfer plate and pushes against the transfer plate when inflated. A pre-filled medicament container is positioned over the pressure transfer plate and is squeezed between the transfer plate and the pump housing cover as the plate is displaced in response to inflation of the flexible bladder. A safety interlock assembly is connected between the pressure regulator and the inflatable bladder and prevents inflation of the bladder unless the housing cover is completely closed. Upon inadvertent opening of the pump, the internal pressurization system is vented to atmosphere.
摘要翻译： 用于与标准预灌注输液药物容器一起使用的便携式移动式输液泵由联接到机械压力调节器的微型压缩气瓶提供动力，所述机械压力调节器以基本上恒定的压力向被充气的气囊提供调节气体。 气囊位于基本上刚性的压力表面和可移动的压力传递板之间，并且在充气时推动传递板。 预填充的药物容器位于压力传递板上方，并随着弹性囊的膨胀而使板移动而在传递板和泵壳体盖之间被挤压。 安全联锁组件连接在压力调节器和可膨胀气囊之间，并防止气囊膨胀，除非外壳盖完全关闭。 在无意中打开泵时，内部加压系统排放到大气中。
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