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31.发明授权Method for lowering cholesterol employing a phosphonomethylphosphinate squalene synthetase inhibitor 失效使用膦酰基甲基次膦酸盐角鲨烯合成酶抑制剂降低胆固醇的方法
公开(公告)号：US5428028A
公开(公告)日：1995-06-27
申请号：US897119
申请日：1992-06-11
Applicant: Scott A. Biller , David R. Magnin
Inventor： Scott A. Biller , David R. Magnin
IPC: A61K31/66 , A61K31/665 , A61K31/67 , A61K31/675 , A61P3/06 , A61P9/10 , C07F9/38 , C07F9/40
CPC classification number: A61K31/66 , A61K31/665 , A61K31/67 , A61K31/675 , C07F9/3821
Abstract: A method is provided for inhibiting cholesterol biosynthesis by inhibiting de novo squalene production employing methylene phosphonoalkylphosphinate compounds.
Abstract translation: 提供了通过使用亚甲基膦酰基烷基次膦酸盐化合物抑制从头角鲨烯生产来抑制胆固醇生物合成的方法。
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