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52 条记录 (耗时 0.026 秒)

    PROCESS FOR THE PRODUCTION OF DRONEDARONE INTERMEDIATES
    35.
    发明申请
    PROCESS FOR THE PRODUCTION OF DRONEDARONE INTERMEDIATES 有权
    生产干粉碎石中间体的方法

    公开(公告)号：US20120077995A1

    公开(公告)日：2012-03-29

    申请号：US13322094

    申请日：2010-05-26

    申请人： Gerhard Kretzschmar ,  Volker Kraft ,  Kai Rossen ,  Joachim Graser

    发明人： Gerhard Kretzschmar ,  Volker Kraft ,  Kai Rossen ,  Joachim Graser

    IPC分类号： C07D307/80

    CPC分类号： C07D307/80

    摘要： A process for the production of Dronedarone intermediates of the formula (I), by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-(4-methoxyphenyl)-ethanone, subsequent treatment of the ester with bases and a zeolite (alumosilicate) catalyst and optional subsequent demethylation. This process can be used for the production of Dronedarone.

    摘要翻译： 通过2-（2-羟基-5-硝基苯基）-1-（4-甲氧基苯基） - 乙酮的酰化生产式（I）的决奈达隆中间体的方法，随后用碱和沸石处理酯 （铝硅酸盐）催化剂和随后的脱甲基化。 该方法可用于生产决奈达隆。

    Process for the Preparation of 1-Aminopiperidine Derivatives
    37.
    发明申请
    Process for the Preparation of 1-Aminopiperidine Derivatives 审中-公开
    1-氨基哌啶衍生物的制备方法

    公开(公告)号：US20080306273A1

    公开(公告)日：2008-12-11

    申请号：US11885922

    申请日：2006-02-28

    申请人： Dieter Most ,  Kai Rossen

    发明人： Dieter Most ,  Kai Rossen

    IPC分类号： C07D295/027 ,  C07D295/023

    CPC分类号： C07D295/30 ,  C07D211/98 ,  C07D295/32

    摘要： The present invention relates to a process for the preparation of compounds of the general formula (I). These are used as important intermediates in the preparation of bioactive substances. Preparation is carried out starting from dicarbonyl compounds of the general formula (II), which are reacted with appropriate hydrazine derivatives of the general formula (III) and subsequently hydrogenated. The present invention also relates to advantageous intermediate compounds.

    摘要翻译： 本发明涉及制备通式（I）化合物的方法。 它们被用作制备生物活性物质的重要中间体。 从通式（II）的二羰基化合物开始制备，其与通式（III）的合适的肼衍生物反应，然后氢化。 本发明还涉及有利的中间体化合物。

    Process for the synthesis of carbapenem intermidiates, and compounds produced
    38.
    发明授权
    Process for the synthesis of carbapenem intermidiates, and compounds produced 失效
    合成碳青霉烯干扰素的方法和所生产的化合物

    公开(公告)号：US06395894B2

    公开(公告)日：2002-05-28

    申请号：US09292257

    申请日：1999-04-15

    申请人： Philip J. Pye ,  Paul J. Reider ,  Kai Rossen ,  Ralph P. Volante

    发明人： Philip J. Pye ,  Paul J. Reider ,  Kai Rossen ,  Ralph P. Volante

    IPC分类号： C07D47714

    CPC分类号： C07D477/04 ,  C07D205/08 ,  Y02P20/55

    摘要： A process of synthesizing a compound of structural formula 6 is disclosed wherein R1 represents H or a suitable protecting group for an alcohol; R2 represents a benzyl, C1-6 alkyl or aryl; Y represents C1-3 alkyl, O, NH or S; X represents O, NH, or S and R5 represents a carboxy protecting group, comprising reacting a compound of formula 5: wherein R1, R2, R5, X and Y are as previously described with a phosphite or phosphonite reagent to produce a compound of formula 6. Further disclosed is an efficient method for the synthesis of a compound of formula 2: which comprises reacting a 4-acyl-2-azetidinone with a titanium, zirconium or hafnium enolate of a 1-hydroxy-2-butanone derivative.

    摘要翻译： 公开了一种合成结构式6的化合物的方法，其中R1表示H或适当的醇保护基; R 2表示苄基，C 1-6烷基或芳基; Y表示C 1-3烷基，O，NH或S; X表示O，NH或S，R 5表示羧基保护基，其包括使式5化合物：其中R 1，R 2，R 5，X和Y如前所述与亚磷酸酯或亚膦酸酯试剂反应以制备式 6.还公开了合成式2化合物的有效方法：其包括使4-酰基-2-氮杂环丁酮与1-羟基-2-丁酮衍生物的钛，锆或锇烯醇化物反应。