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![NOVEL N-ACYL-(3-SUBSTITUTED)-5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR-MEDIATED DISORDERS](/abs-image/US/2018/08/23/US20180237446A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180237446A1
公开(公告)日：2018-08-23
申请号：US15956311
申请日：2018-04-18
申请人： OGEDA SA
发明人： Hamid HOVEYDA , Guillaume DUTHEUIL , Graeme FRASER
IPC分类号： C07D487/04 , A61K31/4985
CPC分类号： C07D487/04 , A61K31/4985
摘要： Novel compounds of Formula I and their use in therapeutic treatments.
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公开(公告)号：US09926325B2
公开(公告)日：2018-03-27
申请号：US14473147
申请日：2014-08-29
申请人： Ogeda SA
IPC分类号： A61K31/407 , A61K31/4985 , C07D487/04
CPC分类号： C07D487/04 , A61K31/407 , A61K31/4985
摘要： The present invention is directed to novel compounds of formula I and their use as therapeutic compounds.
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![NOVEL N-ACYL-(3-SUBSTITUTED)-(8-METHYL)-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR-MEDIATED DISORDERS](/abs-image/US/2018/03/08/US20180065972A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180065972A1
公开(公告)日：2018-03-08
申请号：US15807733
申请日：2017-11-09
申请人： OGEDA SA
发明人： Hamid HOVEYDA , Guillaume DUTHEUIL , Graeme FRASER
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Novel compounds of Formula I methods of manufacturing the compounds and their use in therapeutic treatments are presented.
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![NOVEL CHIRAL SYNTHESIS OF N-ACYL-(3-SUBSTITUTED)-(8-SUBSTITUTED)-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES](/abs-image/US/2017/10/19/US20170298070A1/abs.jpg.150x150.jpg)
34.发明申请公开(公告)号：US20170298070A1
公开(公告)日：2017-10-19
申请号：US15512919
申请日：2015-09-25
申请人： OGEDA SA
发明人： Hamid HOVEYDA , Guillaume DUTHEUIL
IPC分类号： C07D487/04 , C07D241/08
CPC分类号： C07D487/04 , C07D241/08
摘要： Disclosed is a novel chiral synthesis of N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines of Formula (I), avoiding the use of protection/deprotection steps.
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