摘要:
A hinge construction comprising two hinge members provided with a guide track. The guide tracks of each of the hinge members comprise at least three substantially flat, circular segment-shaped track parts, which each extend between first and second track ends and which are distributed at uniform intermediate distances over a corresponding circular circumference, so that the track parts of the hinge members pairwise form a guide for at least one guide element. The hinge members are pivotable relative to each other between a first angular position in which the guide elements are received in the guides so as to be displaceable along the track parts, and a second angular position in which the guide elements are received in the guides so as to be clamped between first and second track ends of the track parts.
摘要:
A digital printing or copying machine (1) is proposed for the one-sided or double-sided printing onto a substrate (5), using at least one toner. The machine (1) includes at least one fixation device (3) for fixing the toner image on the substrate (5). The fixation device (3) has at least one heating device (13) for melting the toner image, past which the substrate (5) can be taken. The machine (1) is distinguished by a guide device (17) for the free floating movement of the substrate (5) in the effective range of the heating device (13).
摘要:
A cladding for a partially-overhanging substrate, such as a tunnel wall which comprises in sequence, from the tunnel wall, a drainage means, a sprayed polymeric membrane and a final layer of concrete. The cladding gives an effective cladding in conditions where the tunnel walls suffer from running water at the time of cladding, is easier to apply and requires less material.
摘要:
Squaric acid derivatives of formula (1) are described: wherein Het is an optionally substituted bicyclic fused ring heteroaromatic group; L2 is a covalent bond or an atom or group —O—, —S—, —C(O)—, —C(S)—, —S(O)—, —S(O)2, —N(R8)— or —C(R8)(R8a)—; Ar2 is an optionally substituted aromatic or heteroaromatic group; Alk is a chain in which R is a carboxylic acid (—CO2H) or a derivative or biostere thereof; R1 is a hydrogen atom or a C1-6alkyl group; L1 is a covalent bond or a linker atom or group; Alk1 is an optionally substituted aliphatic chain; n is zero or the integer 1; R2 is a hydrogen atom or an optionally substituted heteroaliphatic, cycloaliphatic, heterocycloaliphatic, polycycloalphatic, heteropolycycloaliphatic, aromatic or heteroaromatic group other than a 2,6-naphthyridin-1-yl, isoquinolin-1-yl, 2,7-naphthyridin-1-yl or quinazolin-4-yl group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders, or disorders involving the inappropriate growth or migration of cells.
摘要翻译:描述式(1)的方酸衍生物:其中Het是任选取代的双环稠环杂芳族基团; L 2是共价键或-O - , - S - , - C(O) - , -C(S) - , - S(O) - , - S(O)2,-N(R 8) - 或-C(R 8)(R 8a) - ; Ar 2 >是任选取代的芳族或杂芳族基团; Alk是一种链霉素,其中R是羧酸(-CO 2 H)或其衍生物或生物试剂; R 1是氢原子或C 1-6烷基; L 1, 是共价键或连接原子或基团; Alk 1是任选取代的脂族链; n是0或整数1; R 2是氢原子或任选取代的杂脂肪族,脂环族,杂脂族,多环烷基, 除2,6-二氮杂萘-1-基,异喹啉-1-基,2,7-萘啶-1-基或喹唑啉-4-基之外的杂多环脂族,芳族或杂芳族基;以及盐,溶剂合物,水合物和 N-氧化物。化合物能够抑制整联蛋白与其配体的结合 并且可用于预防和治疗免疫或炎性疾病或涉及细胞不适当生长或迁移的病症。
摘要:
A switching device for optionally passing a flow of medium, such as a highly pressurized gas, through a first or second treatment member (2, 3), in which the medium is subjected to a treatment, such as filtration, heating, cooling or the like, comprises a medium inlet, a medium outlet and two distribution valves (1, 5), of which the valve bodies, which are provided with passages, are attached to a common rotation pin (10). For safety's sake, safety valves (12, 13, 14, 15) are arranged in the connections between distribution valves arranged at the inlet and at the oulet and the two treatment members.
摘要:
A digital printing or copying machine (1), and a process which can be carried out with it, for one-sided or double-sided printing of a substrate (5) using at least one toner are proposed. The machine (1) includes at least one fixing device (3) for fixing of a toner image (29) on the substrate (5), having at least one heater (21, 23) for melting the toner image (29), past which the substrate (5) can be guided by a transport device (11) which has one or more transport elements (29, 63 to 71). The machine (1) is characterized in that the heater (21, 23) has at least two melt areas (31, 33, 43 to 47) on the substrate (5) which viewed in the substrate transport direction (15) are arranged in succession and laterally offset to one another.
摘要:
3-Substituted isoquinoline containing squaric acids of formula (1) are described: wherein Ar1 is a 3-substituted isoquinolin-1-yl group; L2 is a covalent bond or a linker atom or group; Ar2 is an optionally substituted aromatic or heteroaromatic chain; Alk is a chain in which R is a carboxylic acid (—CO2H) or a derivative or biostere thereof; R1 is a hydrogen atom or a C1-6alkyl group; L1 is a covalent bond or a linker atom or group; Alk1 is an optionally substituted aliphatic chain; n is zero or the integer 1; R2 is a hydrogen atom or an optionally substituted heteroaliphatic, cycloaliphatic, heterocycloaliphatic, polycycloalphatic, heteropolycycloaliphatic, aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disordes or disorders involving the inappropriate growth or migration of cells.
摘要翻译:描述了含有式(1)的方酸的3-取代的异喹啉:其中Ar1是3-取代的异喹啉-1-基; L2是共价键或连接原子或基团; Ar2是任选取代的芳族或杂芳族链; Alk是其中R是羧酸(-CO 2 H)或其衍生物或生物试剂的链霉素; R 1是氢原子或C 1-6烷基; L 1是共价键或连接原子或基团; Alk1是任选取代的脂族 链; n为零或整数1; R 2为氢原子或任选取代的杂脂族,脂环族,杂环脂族,多环芳族,杂多环脂族,芳族或杂芳族基团;及其盐,溶剂合物,水合物和N-氧化物。 能够抑制整联蛋白与其配体的结合,并且可用于预防和治疗涉及细胞不适当生长或迁移的免疫或炎症性紊乱或紊乱。
摘要:
Compounds of the general formula (1) are described wherein W is a ═N—, and Z and L are described in the specifications. These compounds are phosphodiesterase type IV inhibitors and are useful in the prophylaxis and treatment of diseases such as asthma where an unwanted inflammatory response or muscular spasm is present.
摘要:
A method for frequency modulation synthesis and apparatus for performing the method. The method uses additions rather than multiplies and therefore saves the space and cost of multipliers in circuit implementations. The method saves further resources by using the coordinate rotation digital computer (CORDIC) algorithm to acquire sine values as opposed to an extensive sine look-up table. The method can be implemented with either a dedicated digital circuit or a programmed special purpose processor such as a digital signal processor. The hardware for implementing the method is normally integrated onto a semiconductor device.