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公开(公告)号:US20090005378A1
公开(公告)日:2009-01-01
申请号:US12040536
申请日:2008-02-29
申请人: William D. Arnold , Pierre-Yves Bounaud , Andreas Gosberg , Zhe Li Bounaud , Ian McDonald , Ruo W. Steensma , Mark E. Wilson
发明人: William D. Arnold , Pierre-Yves Bounaud , Andreas Gosberg , Zhe Li Bounaud , Ian McDonald , Ruo W. Steensma , Mark E. Wilson
IPC分类号: A61K31/444 , A61P35/00 , A61K31/496 , A61K31/5377 , A61K31/437
CPC分类号: C07D471/04
摘要: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
摘要翻译: 本发明提供新颖的吡咯并 - 吡啶激酶调节剂和使用新型吡咯并 - 吡啶激酶调节剂治疗由激酶活性介导的疾病的方法。
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公开(公告)号:US07361763B2
公开(公告)日:2008-04-22
申请号:US11192341
申请日:2005-07-27
申请人: William D. Arnold , Pierre Bounaud , Andreas Gosberg , Zhe Li , Ian McDonald , Ruo W. Steensma , Mark E. Wilson
发明人: William D. Arnold , Pierre Bounaud , Andreas Gosberg , Zhe Li , Ian McDonald , Ruo W. Steensma , Mark E. Wilson
IPC分类号: C07D471/02
CPC分类号: C07D471/04
摘要: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
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公开(公告)号:US5535378A
公开(公告)日:1996-07-09
申请号:US177289
申请日:1994-01-04
申请人: William D. Arnold
发明人: William D. Arnold
CPC分类号: G06F7/24 , Y10S707/99931
摘要: The improved Quicksort method of the present invention utilizes two pointers initialized at opposite ends of the array or partition to be sorted and an initial partition value Pvalue located at the center of the array or partition. The value at each of the end pointers is then compared to Pvalue. Sorting is accomplished by recursing the partition process for the two array segments bounded on one side by the final P valve location. This method prevents excessive recursions, and allows the identical array case to recurse to the ideal minimum: Log2(N). Also, by relaxing the offsider criteria to include elements equal to Pvalue, the present invention presents arrays of two valves or a very small range of valves from recursing excessively. Further, the sorting method of the present invention may test the final position of the initial Pvalue to determine whether it is in the center (75%-95%) portion of the array or subarray being positioned. If it is not, the first Pvalue is disregarded, and a new initial Pvalue is selected, preferably randomly selected from the larger subarray bounded on one side by the final Pvalue location resulting from the initial attempt. This method prevents arrays situated in "pipe organ" sequence from recursing excessively. In addition, a maximum recursion depth limit may be specified to force section of a new initial Pvalue if a recursion level exceeds the depth limit.
摘要翻译: 本发明的改进的Quicksort方法利用在要排序的阵列或分区的相对端初始化的两个指针和位于阵列或分区的中心的初始分区值Pvalue。 然后将每个结束指针的值与Pvalue进行比较。 排序是通过对最终P阀位置的一侧限定的两个数组段进行递归分割处理来完成的。 此方法可以防止过多的递归,并允许相同的数组大小写递归到理想的最小值:Log2(N)。 此外,通过放松偏移标准来包括等于P值的元件,本发明提供了两个阀的阵列或非常小范围的阀从过度的递减。 此外,本发明的分类方法可以测试初始Pvalue的最终位置,以确定其是否位于阵列或子阵列的中心(75%-95%)部分中。 如果不是,则忽略第一个P值,并且选择新的初始P值,优选地从在一侧限定由初始尝试所得到的最终P值位置的较大子阵列中随机选择。 这种方法防止位于“管风琴”序列中的阵列过度地递归。 此外,如果递归级别超过深度限制,则可以指定最大递归深度限制来强制新的初始P值的部分。
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公开(公告)号:USD308608S
公开(公告)日:1990-06-19
申请号:US66405
申请日:1987-06-25
申请人: William D. Arnold
设计人: William D. Arnold
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公开(公告)号:USD289243S
公开(公告)日:1987-04-14
申请号:US635588
申请日:1984-07-30
申请人: William D. Arnold
设计人: William D. Arnold
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公开(公告)号:US07906648B2
公开(公告)日:2011-03-15
申请号:US12501328
申请日:2009-07-10
申请人: William D. Arnold , Pierre Bounaud , Andreas Gosberg , Zhe Li , Ian McDonald , Ruo W. Steensma , Mark E. Wilson
发明人: William D. Arnold , Pierre Bounaud , Andreas Gosberg , Zhe Li , Ian McDonald , Ruo W. Steensma , Mark E. Wilson
IPC分类号: C07D471/02 , A01N43/62
CPC分类号: C07D471/04
摘要: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
摘要翻译: 本发明提供新颖的吡咯并 - 吡啶激酶调节剂和使用新型吡咯并 - 吡啶激酶调节剂治疗由激酶活性介导的疾病的方法。
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公开(公告)号:US20100305128A1
公开(公告)日:2010-12-02
申请号:US12851671
申请日:2010-08-06
申请人: William D. Arnold , Chixu Chen , Stefan N. Gradl , Stephanie A. Hopkins , Ruo W. Steensma , Masaki Tomimoto , Mark E. Wilson
发明人: William D. Arnold , Chixu Chen , Stefan N. Gradl , Stephanie A. Hopkins , Ruo W. Steensma , Masaki Tomimoto , Mark E. Wilson
IPC分类号: A61K31/5377 , C07D401/04 , C07D413/14 , C07D403/14 , C12N9/12 , A61K31/497 , A61P35/00
CPC分类号: C07D409/04 , C07D409/14 , C07D417/14
摘要: The present invention provides novel pyrimidinyl-thiophene kinase modulators and methods of using the novel pyrimidinyl-thiophene kinase modulators to treat diseases mediated by kinase activity.
摘要翻译: 本发明提供新的嘧啶基 - 噻吩激酶调节剂和使用新的嘧啶基 - 噻吩激酶调节剂治疗由激酶活性介导的疾病的方法。
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公开(公告)号:US07626021B2
公开(公告)日:2009-12-01
申请号:US11733753
申请日:2007-04-10
申请人: William D. Arnold , Pierre Bounaud , Chixu Chen , Brian Eastman , Andreas Gosberg , Stefan N. Gradl , Stephanie Hopkins , Zhe Li , Ian McDonald , Paul A. Sprengeler , Ruo W. Steensma , Mark E. Wilson
发明人: William D. Arnold , Pierre Bounaud , Chixu Chen , Brian Eastman , Andreas Gosberg , Stefan N. Gradl , Stephanie Hopkins , Zhe Li , Ian McDonald , Paul A. Sprengeler , Ruo W. Steensma , Mark E. Wilson
IPC分类号: C07D471/00 , C07D487/00
CPC分类号: C07D487/04 , C07D471/04
摘要: The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.
摘要翻译: 本发明提供新颖的稠环杂环激酶调节剂和使用新的稠环杂环激酶调节剂来治疗由激酶活性介导的疾病的方法。
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公开(公告)号:US07601839B2
公开(公告)日:2009-10-13
申请号:US12040536
申请日:2008-02-29
申请人: William D. Arnold , Pierre-Yves Bounaud , Andreas Gosberg , Zhe Li Bounaud , Ian McDonald , Ruo W. Steensma , Mark E. Wilson
发明人: William D. Arnold , Pierre-Yves Bounaud , Andreas Gosberg , Zhe Li Bounaud , Ian McDonald , Ruo W. Steensma , Mark E. Wilson
IPC分类号: C07D471/02 , A61K31/535 , A61K31/497 , A61K31/44
CPC分类号: C07D471/04
摘要: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
摘要翻译: 本发明提供新颖的吡咯并 - 吡啶激酶调节剂和使用新型吡咯并 - 吡啶激酶调节剂治疗由激酶活性介导的疾病的方法。
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公开(公告)号:US07452993B2
公开(公告)日:2008-11-18
申请号:US11192318
申请日:2005-07-27
申请人: William D. Arnold , Andreas Gosberg , Zhe Li , Ruo W. Steensma , Mark E. Wilson
发明人: William D. Arnold , Andreas Gosberg , Zhe Li , Ruo W. Steensma , Mark E. Wilson
IPC分类号: C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号: C07D487/04
摘要: The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.
摘要翻译: 本发明提供新颖的稠环杂环激酶调节剂和使用新的稠环杂环激酶调节剂来治疗由激酶活性介导的疾病的方法。
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