公开(公告)号：US4368203A

公开(公告)日：1983-01-11

申请号：US949854

申请日：1978-10-10

申请人： Kazuhiko Okamura ,  Shoji Hirata ,  Yasushi Okumura ,  Yasuo Fukagawa ,  Yasutaka Shimauchi ,  Tomoyuki Ishikura ,  Kageaki Kouno ,  Joseph Lein

发明人： Kazuhiko Okamura ,  Shoji Hirata ,  Yasushi Okumura ,  Yasuo Fukagawa ,  Yasutaka Shimauchi ,  Tomoyuki Ishikura ,  Kageaki Kouno ,  Joseph Lein

IPC分类号： C12P1/06 ,  C07D477/20 ,  C12R1/465 ,  C07D487/04 ,  A61K31/40

CPC分类号： C07D477/20

摘要： A novel antibiotic substance of the formula ##STR1## wherein R.sub.1 is CH.sub.3 and R.sub.2 is --CH.sub.2 --CH.sub.2 -- or R.sub.1 is H and R.sub.2 is --CH.dbd.CH--; and R.sub.3 represents hydrogen, lower alkyl or triphenylmethyl,and including the salts of the compound of formula (I) wherein R.sub.3 is hydrogen, said antibiotic substance having strong antibiotic activity and .beta.-lactamase inhibiting effect, and a method for producing the same by aerobic cultivation of Streptomyces A271.

摘要翻译： 式（Ⅰ）的新型抗生素物质，其中R 1为CH 3且R 2为-CH 2 -CH 2 - 或R 1为H且R 2为-CH = CH-; 并且R 3表示氢，低级烷基或三苯基甲基，并且包括其中R 3是氢的式（I）化合物的盐，所述抗生素具有很强的抗生素活性和β-内酰胺酶抑制作用的方法及其生产方法 培养链霉菌A271。

公开(公告)号：US4337199A

公开(公告)日：1982-06-29

申请号：US147146

申请日：1980-05-06

申请人： Takeo Yoshioka ,  Kenichi Yamamoto ,  Kaoru Yamada ,  Yasuyuki Kato ,  Yasutaka Shimauchi ,  Tomoyuki Ishikura

发明人： Takeo Yoshioka ,  Kenichi Yamamoto ,  Kaoru Yamada ,  Yasuyuki Kato ,  Yasutaka Shimauchi ,  Tomoyuki Ishikura

IPC分类号： C07D477/20 ,  C07D487/04 ,  A61K31/40

CPC分类号： C07D477/20

摘要： Novel antibiotic .beta.-lactam compounds, i.e. 7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives of the following formula ##STR1## wherein R.sub.1 represents a hydrogen atom, a methyl group or a hydroxyl group,R.sub.2 represents a lower alkyl group, a hydroxy lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkanoyloxy-lower alkyl group, a cyclohexyl group, a phenyl group or a 5- or 6-membered aromatic heterocyclic group containing 1 or 2 nitrogen atoms, andR.sub.3 represents a hydrogen atom, a lower alkyl group, or a substituted or unsubstituted aralkyl group containing 7 to 20 carbon atoms,and the salts thereof; processes for production thereof; use thereof as antimicrobial agents; and novel intermediates for production of the compounds of formula (I).

摘要翻译： 新颖的抗生素β-内酰胺化合物，即下式的7-氧代-1-氮杂双环（3.2.0）庚-2-烯-2-羧酸衍生物其中R1代表氢原子，甲基 基团或羟基，R2表示低级烷基，羟基低级烷基，低级烷氧基 - 低级烷基，低级烷酰氧基 - 低级烷基，环己基，苯基或5-或6-元 含有1或2个氮原子的芳族杂环基，R 3表示氢原子，低级烷基或取代或未取代的含有7〜20个碳原子的芳烷基及其盐; 生产过程; 其用作抗微生物剂; 和用于制备式（I）化合物的新型中间体。